Effects of melatonin ingestion on physical performance and biochemical responses following exhaustive running exercise in soccer players

Farjallah, Mohamed Amine; Graja, Ahmed; Mahmoud, Lobna Ben; Ghattassi, Kais; Boudaya, M.; Driss, Tarak; Jamoussi, Kamel; Sahnoun, Zouheir; Souissi, Nizar

doi:10.5114/biolsport.2022.106385

Cited by 7 publications

(51 citation statements)

References 36 publications

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“…Appositely, we observed that MEL ingestion prevented an upsurge of AOPP level. Likewise, previous investigations recommended MEL to counteract exercise-induced oxidative stress [1,8,10,25]. This may be explained by the extremely important antioxidant action of MEL and its metabolites produced as a result of the neutralization of ROS [9].…”

Section: Discussionmentioning

confidence: 93%

“…After the TC, SOD activity increased in the MEL group. Accordingly, previous studies showed that MEL ingestion amplified the activity of antioxidant enzymes [1,10]. MEL is an…”

Section: Discussionmentioning

confidence: 95%

“…This may help athletes to train better, since it has been shown that an elevated activity of these enzymes was correlated with muscle cramps [14]. Accordingly, previous studies have found an important decrease in muscle injury markers after MEL ingestion [1,8,25]. It also enhanced muscle healing and regeneration in rats suffering from muscle injury [11].…”

Section: Plos Onementioning

confidence: 95%

“…Skeletal muscle may undergo cellular damage especially in response to eccentric and exhaustive exercise [1]. It often persists for many days after finishing exercise and symptoms mostly include increased reactive oxygen species (ROS), disruption of muscle fiber structures and integrity, release of intra-myocellular proteins into the circulation and elevations in markers of inflammation and various interleukins [2].…”

Section: Introductionmentioning

confidence: 99%

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Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players

et al. 2022

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Melatonin has been proved to have positive effects on cellular damage and metabolic regulation. The aim of the study was to determine the effect of melatonin supplementation during an intensive training period on physical performance decline, oxidative stress and cellular damage state. The investigation was conducted on 20 soccer players who participated in an exhaustive six-day training schedule associated with daily 5 mg oral melatonin or placebo ingestion. Resting blood samples and physical performance were measured before and after the training period. The mixed 2-way ANOVA (group x training camp) showed that compared to placebo, melatonin intake prevented an increase in advanced oxidation protein products (p>0.05) and increased the antioxidant enzyme activity (i.e., superoxide dismutase; p<0.001). In addition, melatonin prevented an increase of biomarkers of renal function (e.g., creatinine; p>0.05) and biomarkers of muscle (e.g., creatine kinase; p>0.05) and liver (e.g., gamma-glutamyltransferase; p>0.05) damage. Furthermore, melatonin alleviated the deterioration in physical performance (countermovement jump, five-jump test and 20-m sprint; p>0.05). In conclusion, the obtained data showed increased oxidative stress and renal, muscle and liver damage in professional soccer players during an exhaustive training schedule. Melatonin intake during the training period exerts beneficial effects on physical performance and protects tissues against the deleterious effects of reactive oxygen species and cellular damage.

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Section: Discussionmentioning

confidence: 93%

“…After the TC, SOD activity increased in the MEL group. Accordingly, previous studies showed that MEL ingestion amplified the activity of antioxidant enzymes [1,10]. MEL is an…”

Section: Discussionmentioning

confidence: 95%

Section: Plos Onementioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players

et al. 2022

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“…The controlled release of pharmaceutical preparations is an important aspect that doctors take into account both when prescribing drug doses and when administering food supplements [ 59 , 60 , 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release

et al. 2023

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Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene (w/w), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, w/w). For the comparative evaluation of the membranes’ performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, w/w/w) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm2·per day (sEPDM), 1.6 mg/ cm2·per day (Chi/sEPDM), and 1.25 mg/cm2·per day (Mel/Chi/SEPDM).

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Nocturnal Melatonin Ingestion Improves Soccer Players’ Short-Term Maximal Performances on the Following Day

Ghattassi,

Farjallah,

Graja

et al. 2024

Research Quarterly for Exercise and Sport

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Effects of melatonin ingestion on physical performance and biochemical responses following exhaustive running exercise in soccer players

Cited by 7 publications

References 36 publications

Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players

Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players

Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release

Nocturnal Melatonin Ingestion Improves Soccer Players’ Short-Term Maximal Performances on the Following Day

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