Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study

Effects of long‐term exposure to ramelteon, a melatonin receptor agonist, on endocrine function in adults with chronic insomnia

“…However, a study of seven women showed that a single dose of melatonin 4 mg significantly increased the levels of prolactin (Terzolo et al, 1993). In a study comparing older (aged 50-62 years) and younger (aged 42-49 years) women, long-term melatonin 3 mg treatment resulted in significant increases in T3 concentrations at months 3 and 6 and a significant increase in T4 concentrations at month 6 for both age groups (all p < 0.05) (Bellipanni et al, 2001). In younger women only, 6 months of melatonin 3 mg nightly led to a significant decrease in plasma LH (Bellipanni et al, 2001).…”

“…Several studies have examined the effects of exogenous melatonin on hormonal indices in human subjects of varying ages in both men and women, using doses of melatonin ranging from 1.5 to 5 mg and durations of exposure from 1 to 90 days (Bellipanni et al, 2001;Forsling et al, 1999;KostoglouAthanassiou et al, 1998;Rajaratnam et al, 2003). Most of the studies were quite small, and the dependent measures employed varied from study to study; thus it was difficult to determine whether there was any consistent endocrine response to exogenous melatonin administration in humans.…”

Premature Ovarian Failure

“…Tests reveal a hypergonadotropic-hypogonadic hormone profile (also referred to as primary hypogonadism), which is characterised by low oestradiol (E 2 ) levels (< 20 pg/ml), elevated gonadotropin levels (follicle-stimulating hormone [FSH] > 20 IU/l), low anti-Müllerian hormone (AMH) levels -< 0.5 ng/ml (< 1 ng/ml), and low inhibin B levels [1,11,12].…”

“…Recently, melatonin supplementation has been described as a treatment modality in case of perimenopause [11,12,53]. It has been reported to have a positive effect on thyroid function and increasing gonadotropin levels.…”

Melatonin: pregnancy and labor

“…Мелатонин как регулятор суточных и годовых циклов физи-ологических функций организма и, в частности, репродуктив-ной системы животных и человека в последние годы все боль-ше привлекает внимание исследователей [19,34,87,88,105]. Однако не только изменения продукции мелатонина в зави-симости от продолжительности светового и темного времени суток, определяющие сезонные и суточные ритмы перестрой-ки системы репродукции, но его уникальные антиоксидант-ные, иммуномодулирующие свойства так же, как и участие в метаболических процессах на клеточном и тканевом уров-нях обеспечивают репродуктивное здоровье человека [22,39,61,91,102].…”