Effects of melatonin in elderly patients with sleep disturbance: a pilot study

Fainstein, Isidoro; Bonetto, Alberto; Brusco, Luis I.; Cardinali, Daniel P.

doi:10.1016/s0011-393x(97)80066-5

Cited by 77 publications

(84 citation statements)

References 18 publications

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“…Furthermore, melatonin administered nightly for 4 weeks improved certain aspects of cognition in healthy elderly subjects (Peck et al, 2004). Fainstein et al (1997) noted that melatonin at bedtime augmented the quality of alertness that is impaired with hypnotics (benzodiazepines). Most of these studies have used immediate-release melatonin, which induced elevated melatonin level for a short duration due to its short half-life (34-50 min) Vakkuri et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Otmani

Demazieres

Staner

et al. 2008

Human Psychopharmacology

116

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Section: Introductionmentioning

confidence: 99%

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Otmani

Demazieres

Staner

et al. 2008

Human Psychopharmacology

116

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show abstract

“…for 21 days) was conducted in a small nonhomogeneous group of elderly patients with primary insomnia and with insomnia associated with depression or dementia [9]. The results indicated that melatonin therapy can be beneficial in the initiation and maintenance of sleep in patients suffering from insomnia alone or associated with depression symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-eight females and 13 males (mean age 74 B 12 years) were included in the first study [9]. Patients were divided into 3 groups for analysis: (a) patients with sleep disturbances alone (n = 22); (b) patients with sleep disturbance together with signs of depression (n = 9); (c) patients with sleep disorder and dementia of the degenerate (AD) or vascular type (n = 10).…”

Section: Methodsmentioning

confidence: 99%

Effect of Melatonin in Selected Populations of Sleep-Disturbed Patients

et al. 1999

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In an open pilot study on the efficacy of melatonin in the treatment of sleep disorders, patients with sleep disturbances alone, patients with sleep disturbances and signs of depression and patients with sleep disorders and dementia received 3 mg melatonin p.o. for 21 days, at bed time. After 2–3 days of treatment, melatonin significantly augmented sleep quality and decreased the number of awakening episodes in patients with sleep disturbances associated or not with depression. Estimates of next-day alertness improved significantly only in patients with primary insomnia. Agitated behavior at night (sundowning) decreased significantly in dementia patients. In a second retrospective study, 14 Alzheimer’s disease (AD) patients received 9 mg melatonin daily for 22–35 months. A significant improvement of sleep quality was found, while there were no significant differences between initial and final neuropsychological evaluation (Functional Assessment Tool for AD, Mini-Mental). The results indicate that melatonin can be useful to treat sleep disturbances in elderly insomniacs and AD patients.

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“…In one study 7 out of 10 patients showed improvement after taking melatonin 3mg PO QHS for 21 days [28].…”

Section: Sleep-wake Abnormalities Circadian Rhythm Disturbances Andmentioning

confidence: 98%

Melatonin: Therapeutic Intervention in Mild Cognitive Impairment and Alzheimer Disease

Grandy¹

2013

J Neurol Neurophysiol

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Effects of melatonin in elderly patients with sleep disturbance: a pilot study

Cited by 77 publications

References 18 publications

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Effects of prolonged‐release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers

Effect of Melatonin in Selected Populations of Sleep-Disturbed Patients

Melatonin: Therapeutic Intervention in Mild Cognitive Impairment and Alzheimer Disease

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