Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial

Pahlavani, Naseh; Malekahmadi, Mahsa; Sedaghat, Alireza; Rostami, Amirabbas; Alkadir, Ola Kamal A.; Taifi, Ahmed; Ranjbar, Golnaz; Sahebkar, Amirhossein; Abdelbasset, Walid Kamal; Beigmohammadi, Mohammad Taghi; Mir, Mahdieh; Moghaddam, Ahmad Bagheri; Tabesh, Hamed; Sadeghi, Omid; Navashenaq, Jamshid Gholizadeh; Firouzi, Safieh; Najafi, Mohammad; Safarian, Mohammad; Ghayour‐Mobarhan, Majid

doi:10.1159/000523766

Cited by 14 publications

(12 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 1 lists general information about the included studies. Seven studies had sufficient information for MDA (Darvishi et al, 2020; Ebeid et al, 2016; Gao et al, 2018; Gholaminejad et al, 2019; Pahlavani et al, 2022; Soleimani et al, 2021; Zhao et al, 2016), three for SOD (Afsharpour et al, 2019; Gao et al, 2018; Zhao et al, 2016), three for GPX (Afsharpour et al, 2019; Gao et al, 2018; Zhao et al, 2016), four for TAC (Afsharpour et al, 2019; Ebeid et al, 2016; Gholaminejad et al, 2019; Soleimani et al, 2021), and four for GSH (Gao et al, 2018; Mujica et al, 2017; Soleimani et al, 2021; Zhao et al, 2016). Studies were carried out in Iran (Afsharpour et al, 2019; Darvishi et al, 2020; Gholaminejad et al, 2019; Soleimani et al, 2021), Egypt (Ebeid et al, 2016), and China (Gao et al, 2018; Mujica et al, 2017; Zhao et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…The random sequence generation was well observed in five studies (Afsharpour et al, 2019; Darvishi et al, 2020; Gholaminejad et al, 2019; Mujica et al, 2017; Soleimani et al, 2021). Only four studies (Ebeid et al, 2016; Gao et al, 2018; Pahlavani et al, 2022; Zhao et al, 2016) did not mention allocation concealment. Four studies were conducted with double‐blinding (Afsharpour et al, 2019; Darvishi et al, 2020; Gholaminejad et al, 2019; Mujica et al, 2017), and one was conducted with triple‐blinding (Soleimani et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…All studies were performed between 2015 and 2022. Only four studies (Ebeid et al, 2016;Gao et al, 2018;Pahlavani et al, 2022;Zhao et al, 2016) did not mention allocation concealment.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

The effect of propolis supplementation in improving antioxidant status: A systematic review and meta‐analysis of controlled clinical trials

Nazari‐Bonab,

Jamilian,

Radkhah

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

The present study aimed to assess the effect of propolis supplementation on oxidative status, a key contributor to the etiology of many chronic diseases. A systematic search of multiple databases, including Web of Science, SCOPUS, Embase, PubMed, and Google Scholar, was conducted from inception to October 2022 to identify articles examining the effect of propolis on glutathione (GSH), glutathione peroxidase (GPX), total antioxidant capacity (TAC), superoxide dismutase (SOD), and malondialdehyde (MDA) levels. The quality of the included studies was evaluated using the Cochrane Collaboration tool. A total of nine studies were included in the final analysis, and a random‐effects model was used to pool the estimated effects. Results showed that propolis supplementation significantly increased the levels of GSH (SMD = 3.16; 95% CI: 1.15, 5.18; I2 = 97.2%), GPX (SMD = 0.56; 95% CI: 0.07, 1.05; p = 0.025; I2 = 62.3%), and TAC (SMD = 3.26; 95% CI: 0.89, 5.62; I2 = 97.8%, p < 0.001). However, the effect of propolis on SOD was not significant (SMD = 0.05; 95% CI: −0.25, 0.34; I2 = 0.0%). Although the MDA concentration was not significantly decreased overall (SMD = −0.85, 95% CI: −1.70, 0.09; I2 = 93.3%), a significant decrease in MDA levels was observed at doses ≥1000 mg/day (SMD = −1.90; 95% CI: −2.97, −0.82; I2 = 86.4) and supplementation durations of less than 11 weeks (SMD = −1.56; 95% CI: −2.60, −0.51; I2 = 90.4). These results suggest that propolis is a safe supplement with a beneficial effect on GSH, GPX, and TAC levels and may be an effective adjunctive therapy for diseases where oxidative stress is a key factor in the etiology. However, further high‐quality studies are necessary to make more precise and comprehensive recommendations given the limited number of studies, clinical diversity, and other limitations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of propolis supplementation in improving antioxidant status: A systematic review and meta‐analysis of controlled clinical trials

Nazari‐Bonab,

Jamilian,

Radkhah

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…This combination could potentially reduce the length of hospital stay and improve survival rates for ICU patients. [8,10,11] Procalcitonin is recognized as a biomarker commonly used in the diagnosis of bacterial infections and sepsis. It appears that procalcitonin can be used effectively as a sepsis marker in burn patients.…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin and blood lactate level as predictive biomarkers in pediatric multiple trauma patients’ pediatric intensive care outcomes: A retrospective observational study

Colak,

Arda Kilinc,

Güven

et al. 2023

Medicine

View full text Add to dashboard Cite

Pediatric trauma represents a significant source of morbidity and mortality in children, encompassing a broad spectrum of injuries. Despite advancements in the treatment and prevention of injuries, the risk of trauma in children remains a persistent concern. Severe trauma cases often necessitate admission to a pediatric intensive care unit (PICU). Procalcitonin, an essential biomarker that elevates bacterial infections and trauma, and elevated lactate levels can signal adverse outcomes in critically ill patients. This study retrospectively examined pediatric patients with multiple trauma treated at the Başakşehir Çam and Sakura City Hospital PICU between 2021 and 2023. The analysis sought to evaluate the relationship between initial procalcitonin and lactate levels with the duration of stay in the PICU, the length of invasive mechanical ventilation (IMV), and the duration of inotropic support. Furthermore, a comparison was made between procalcitonin and lactate levels in survivors and non-survivors, analyzing their potential influence on PICU outcomes and mortality. For pediatric multi-trauma patients, the median duration of stay in the PICU was found to be 3 days. Among these patients, 32% necessitated IMV support and utilized it for a median of 5 days. Additionally, 36% of these patients were provided inotropic drug support for a median time of 6 days. The observed mortality rate was 11%. Procalcitonin and blood lactate levels were found to have significant predictive power for mortality with odds ratios of 1.05 (P = .04) and 1.87 (P = .02), respectively. Both blood lactate and procalcitonin levels were significantly associated with the duration of IMV support, the period of inotropic drug administration, and the length of PICU stay (P < .01; P < .01; P < .01, respectively). this research underscores the prognostic value of initial procalcitonin and lactate levels about the intensive care trajectory of pediatric trauma patients. The findings suggest that both procalcitonin and lactate levels may play pivotal roles as potential biomarkers in predicting and managing clinical outcomes in this population.

show abstract

“…Traumatic brain injury (TBI) is associated with immune system dysfunction and is often the result of a collision with a motor vehicle, violence, or a fall [ 9 – 11 ]. One of the more valuable therapeutic agents to decrease illnesses triggered by oxidative stress is natural compound-based antioxidants because they play a protective role in preventing the generation of free radicals [ 12 , 13 ]. Recently, the importance of diet and antioxidants and complementary therapies in critically ill patients has been identified [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Probiotics Supplementation on CRP, IL-6, and Length of ICU Stay in Traumatic Brain Injuries and Multiple Trauma Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Noshadi

Heidari

Kermanshahi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background and Purpose. Since probiotics are considered to use beneficial health impacts by increasing the host’s immunological response, we reviewed the advantages of probiotic therapy in patients with traumatic brain injury and multiple traumas. Method. This meta-analysis aims to evaluate the effectiveness of probiotics in reducing inflammatory biomarkers and the length of intensive care unit (ICU) stays. PubMed-Medline, SCOPUS, Embase, and Google Scholar databases up to July 2021 were searched. The meta-analysis was carried out using random-effect analysis. To determine the sources of heterogeneity, subgroup analyses were performed. In case of the presence of publication bias, trim and fill analysis was carried out. The Cochrane Collaboration tool was used for checking the quality assessment. We hypothesized that probiotics would improve inflammatory markers (CRP and IL-6) and the length of ICU stay in traumatic brain injury and multiple trauma patients. Results. The present meta-analysis, which includes a total of seven studies, showed that there were no significant effects of probiotics supplementation on interleukin (IL)-6 (Hedges’s g = −2.46 pg/ml; 95% CI: −12.16, 7.25; P = 0.39 ), C-reactive protein (CRP) (Hedges’s g = −1.10 mg/L; 95% CI: −2.27, 0.06; P = 0.06 ), and the length of staying in ICU. The overall number of RCTs included in the analysis and the total sample size were insufficient to make firm conclusions. Conclusion. As a result, more carefully designed RCTs are needed to investigate the effect of probiotics on inflammatory biomarkers and the length of ICU stay in traumatic brain injuries and multiple trauma patients in greater detail.

show abstract

Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial

Cited by 14 publications

References 71 publications

The effect of propolis supplementation in improving antioxidant status: A systematic review and meta‐analysis of controlled clinical trials

The effect of propolis supplementation in improving antioxidant status: A systematic review and meta‐analysis of controlled clinical trials

Procalcitonin and blood lactate level as predictive biomarkers in pediatric multiple trauma patients’ pediatric intensive care outcomes: A retrospective observational study

Effects of Probiotics Supplementation on CRP, IL-6, and Length of ICU Stay in Traumatic Brain Injuries and Multiple Trauma Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Contact Info

Product

Resources

About