Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy

Abstract

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Is Decorin a Promising New Agent for Facial Nerve Regeneration? An Experimental Study

“…Although peripheral motor nerves have regeneration capacity, full healing is not achieved if total nerve laceration is present [Batioglu-Karaaltin et al, 2016]. The outcomes of end-toend anastomosis are not always satisfactory because of poor axonal regeneration and synkinesis [Chu et al, 2018;Edizer et al, 2019]. Therefore, trophic factor transportation to the injury region has been suggested to be beneficial in supporting nerve repair [Alan et al, 2011].…”

“…In total axonal nerve injury, end-toend anastomosis, which is called neurorrhaphy (NR), is the ideal treatment method [Beris et al, 2019]. Various agents, such as melatonin, lipoic acid, and neurotrophic nerve growth factors, have been experimentally used to enhance FN regeneration [Ma et al, 2018;Tekdemir et al, 2018;Edizer et al, 2019]. As steroids decrease the oedema around the nerve and lipoic acid has antioxidant features, both are used in enhancing FN regeneration [Tekdemir et al, 2018].…”

New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors

“…Melatonin has possible therapeutic effects for treating neurodegenerative diseases, cardiovascular diseases, and many other clinical complications ( Amer, Othamn, & El-Missiry, 2021 ). Melatonin also shows immunomodulatory consequences which depend on its ability to augment the cytokine levels and antioxidant properties ( Edizer et al, 2019 ; Kuthati et al, 2020 ).…”

Melatonin signalling in Schwann cells during neuroregeneration

“…Recent studies using various lesion models of the central and peripheral nervous system have indicated melatonin–induced neuroprotective effects occurring in a dose–dependent manner and unfolding their full magnitude at supraphysiological concentrations around 50 mg/kg in a (systemic) long–term administration ( Gül et al, 2005 ; Shokouhi et al, 2008 ; Atik et al, 2011 ; Li et al, 2014 ). Systemic intraperitoneal administration of melatonin in mice after facial nerve injury has been shown to preserve the thickness of myelin sheaths, whereas given electrophysiological parameters of nerve conduction that included the latency and amplitude of the compound muscle action potentials have remained unaltered ( Tuna Edizer et al, 2019 ). Edizer and colleagues have also observed reduced immunohistochemical reactivity to collagen III and V in the treated nerve as well as minimal immune infiltration and normal structure of axons and neurofilaments ( Tuna Edizer et al, 2019 ); for more details see Table 1 .…”

“…Systemic intraperitoneal administration of melatonin in mice after facial nerve injury has been shown to preserve the thickness of myelin sheaths, whereas given electrophysiological parameters of nerve conduction that included the latency and amplitude of the compound muscle action potentials have remained unaltered ( Tuna Edizer et al, 2019 ). Edizer and colleagues have also observed reduced immunohistochemical reactivity to collagen III and V in the treated nerve as well as minimal immune infiltration and normal structure of axons and neurofilaments ( Tuna Edizer et al, 2019 ); for more details see Table 1 . Of note, also topically applied melatonin has been found to support regeneration, yet not at the same level of magnitude as to when the hormone had been administered systemically ( Tuna Edizer et al, 2019 ).…”