Effects of Melatonin Administration in Different Time Modes on Morphofunctional Indices of the Hypothalamic Serotonergic Neurons in Obese Rats

Kalmukova, O.; Yurchenko, A.; Кyryk, V.; Nepomnyaschy, Valentin; Savchuk, Olexiy; Dzerzhynsky, M.

doi:10.1007/s11062-019-09771-2

Cited by 3 publications

(1 citation statement)

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“…This method is based on the production of fluorophores upon condensation of the biogenic amines with formaldehyde. The technique was partly modified [19].…”

Section: Histochemical Analysis For Serotonin Detectionmentioning

confidence: 99%

The Kidney Beans (Phaseolus vulgaris) Pods Extract Affects the Central and Peripheral Serotonergic Systems in Rats With High-Calorie Diet-Induced Obesity

et al. 2021

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“…This method is based on the production of fluorophores upon condensation of the biogenic amines with formaldehyde. The technique was partly modified [19].…”

Section: Histochemical Analysis For Serotonin Detectionmentioning

confidence: 99%

The Kidney Beans (Phaseolus vulgaris) Pods Extract Affects the Central and Peripheral Serotonergic Systems in Rats With High-Calorie Diet-Induced Obesity

et al. 2021

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Nano-melatonin and-histidine modulate adipokines and neurotransmitters to improve cognition in HFD-fed rats: A formula to study

et al. 2023

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Cafeteria diet decreases sucrose preference and increases the sensitivity of risperidone in the caloric intake of Wistar rats

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Rocha-Gomes

Teixeira

et al. 2021

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Purpose The purpose of this study was to evaluate the increase in sensitivity of a single risperidone administration in relation to energy intake of Wistar rats treated with cafeteria diet from birth to adulthood (119 days). Design/methodology/approach During the lactation period, six litters of Wistar rats (dam + 8 pups each litter) were fed one of the following two diets: Control (n = 3) or Cafeteria (n = 3) diets and water ad libitum. After weaning, the males were placed in individual cages, receiving the same diet offered to their respective dams (Control = 18; or Cafeteria = 18) until adulthood (119 postnatal days). The following parameters were evaluated: food and energy intake; macronutrient intake; weight gain; adipose tissue relative weight; sucrose preference; food intake after an administration of risperidone (0.1 mg/kg body weight). Findings The Cafeteria group showed a higher energy intake in relation to the Control group (p < 0.001). The consumption of energy beyond the individual needs can be understood as a hyperphagic condition. Also, the Cafeteria group reported greater weight gain (p = 0.048) and accumulation of adipose tissue (p < 0.001) with respect to the Control group. These results indicate that the cafeteria diet generated obesity in animals. The Cafeteria group showed reduced sucrose preference (p = 0.031), which is associated with the development of anhedonia-like behavior. In the food intake test, risperidone showed a greater sensitivity in Cafeteria animals, promoting a decrease in their energy intake in relation to the Control group that received risperidone (p = 0.040). Originality/value The cafeteria diet promoted hyperphagia, anhedonia-like behavior and obesity in animals. Acute risperidone administration showed greater sensitivity in the Cafeteria group, with a decrease in energy intake. The reported effects may be related to a downregulation of the dopaminergic system in the NAc region.

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Effects of Melatonin Administration in Different Time Modes on Morphofunctional Indices of the Hypothalamic Serotonergic Neurons in Obese Rats

Cited by 3 publications

References 50 publications

The Kidney Beans (Phaseolus vulgaris) Pods Extract Affects the Central and Peripheral Serotonergic Systems in Rats With High-Calorie Diet-Induced Obesity

The Kidney Beans (Phaseolus vulgaris) Pods Extract Affects the Central and Peripheral Serotonergic Systems in Rats With High-Calorie Diet-Induced Obesity

Nano-melatonin and-histidine modulate adipokines and neurotransmitters to improve cognition in HFD-fed rats: A formula to study

Cafeteria diet decreases sucrose preference and increases the sensitivity of risperidone in the caloric intake of Wistar rats

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