Effects of Medicinal Plants and Flavonoids on Parkinson's Disease, a Review on Basic and Clinical Evidences

Khazdair, Mohammad Reza; Kianmehr, Majid; Anaeigoudari, Akbar

doi:10.34172/apb.2021.026

Cited by 12 publications

(12 citation statements)

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“…e anti-inflammatory and antiallergic properties of quercetin on respiratory and food allergies were also shown [67,68]. Antiallergic [69], neuroprotective [70], antiinflammatory, and antioxidant activities [71] were shown for derivatives of A. cepa including flavonoids, organosulfur, and phenols. e polyphenol compounds present in onions showed stimulating effects on the immune system in the aging process [72,73], and some phenolics in onions showed antiplatelet properties [74].…”

Section: Traditional and Pharmacological Effectsmentioning

confidence: 92%

“…The anti-inflammatory and antiallergic properties of quercetin on respiratory and food allergies were also shown [ 67 , 68 ]. Antiallergic [ 69 ], neuroprotective [ 70 ], anti-inflammatory, and antioxidant activities [ 71 ] were shown for derivatives of A. cepa including flavonoids, organosulfur, and phenols.…”

Section: Traditional and Pharmacological Effectsmentioning

confidence: 99%

“…Constituents on Asthma (35,70, and 140 mg/ kg b.w.) and dexamethasone (1.25 μg/mL) effects on oxidants, antioxidants, and immunological markers in the bronchoalveolar lavage fluids (BALF) of OVA-sensitized rats revealed concentration-dependent improvement of these markers in treated groups.…”

Section: Preventive Effects Of a Cepa And Itsmentioning

confidence: 99%

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Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Beigoli

Behrouz

Memarzia

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The health benefits of Allium cepa (A. cepa) have been proclaimed for centuries. Various pharmacological and therapeutic effects on respiratory, allergic, and immunologic disorders are shown by A. cepa and its constituents. Flavonoids such as quercetin and kaempferol, alk(en)yl cysteine sulfoxides including S-methyl cysteine sulfoxide and S-propyl cysteine sulfoxide, cycloalliin, thiosulfinates, and sulfides are the main compounds of the plant. A. cepa displays broad-spectrum pharmacological activities including antioxidant, anti-inflammatory, antihypertensive, and antidiabetic effects. Our objective in this review is to present the effects of A. cepa and its constituents on respiratory, allergic, and immunologic disorders. Different online databases were searched to find articles related to the effect of A. cepa extracts and its constituents on respiratory, allergic, and immunologic disorders until the end of December 2020 using keywords such as onion, A. cepa, constituents of A. cepa, therapeutic effects and pharmacological effects, and respiratory, allergic, and immunologic disorders. Extracts and constituents of A. cepa showed tracheal smooth muscle relaxant effects, indicating possible bronchodilator activities or relieving effects on obstructive respiratory diseases. In experimental animal models of different respiratory diseases, the preventive effect of various extracts and constituents of A. cepa was induced by their antioxidant, immunomodulatory, and anti-inflammatory effects. The preventive effects of the plant and its components on lung disorders induced by exposure to noxious agents as well as lung cancer, lung infection, and allergic and immunologic disorders were also indicated in the experimental and clinical studies. Therefore, this review may be considered a scientific basis for development of therapies using this plant, to improve respiratory, allergic, and immunologic disorders.

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Section: Traditional and Pharmacological Effectsmentioning

confidence: 92%

Section: Traditional and Pharmacological Effectsmentioning

confidence: 99%

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Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Beigoli

Behrouz

Memarzia

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Its compounds might mitigate neurodegeneration by lowering ROS levels in the brain, preventing nitric oxide (NO) accumulation and promoting the enhancement of α‐synuclein clearance. They also act on the inhibition of MAOs and the modulation of the content of DA (Amro, Teoh, Norzana, & Srijit, 2018; Khazdair, Kianmehr, & Anaeigoudari, 2021; Peterson, 2020).…”

Section: Phytotherapy For Neurodegenerative Dementiasmentioning

confidence: 99%

Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal

Acero

Ortega

Villagrasa

et al. 2023

Phytotherapy Research

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The incidence and prevalence of age‐related neurodegenerative dementias have been increasing. There is no curative therapy and conventional drug treatment can cause problems for patients. Medicinal plants traditionally used for problems associated with ageing are emerging as a therapeutic resource. The main aim is to give a proposal for use and future research based on scientific knowledge and tradition. A literature search was conducted in several searchable databases. The keywords used were related to neurodegenerative dementias, ageing and medicinal plants. Boolean operators and filters were used to focus the search. As a result, there is current clinical and preclinical scientific information on 49 species used in traditional medicine for ageing‐related problems, including neurodegenerative dementias. There are preclinical and clinical scientific evidences on their properties against protein aggregates in the central nervous system and their effects on neuroinflammation, apoptosis dysregulation, mitochondrial dysfunction, gabaergic, glutamatergic and dopaminergic systems alterations, monoamine oxidase alterations, serotonin depletion and oestrogenic protection. In conclusion, the potential therapeutic effect of the different medicinal plants depends on the type of neurodegenerative dementia and its stage of development, but more clinical and preclinical research is needed to find better, safer and more effective treatments.

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“…It is revealed that flavonoid, saponin, essential oil and carotenoid are the potential primary active components in CoL ( Machado et al, 2014 ). Thereinto, flavonoid has shown numerous health benefits, including the promising neuroprotective effect against PD ( Khazdair et al, 2021 ). Therefore, we hypothesized that the extract of CoL (hereafter referred as ECoL) may have potential activity for the prevention of PD.…”

Section: Introductionmentioning

confidence: 99%

The alleviative effect of Calendula officinalis L. extract against Parkinson’s disease-like pathology in zebrafish via the involvement of autophagy activation

Wang

Ping

et al. 2023

Front. Neurosci.

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IntroductionParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. However, effective preventative or therapeutic agents for PD remain largely limited. Marigold Calendula officinalis L. (CoL) has been reported to possess a wide range of biological activities, but its neuroprotective activity including anti-neurodegenerative diseases is unclear. Here, we aim to investigate whether the extract of CoL (ECoL) has therapeutic activity on PD.MethodsWe identified the chemical composition of flavonoid, an important active ingredient in ECoL, by a targeted HPLC-Q-TOF-MS analysis. Subsequently, we evaluated the anti-PD effect of ECoL by using zebrafish PD model induced by 1-methyl-4-phenyl-1-1,2,3,6-tetrahydropyridine (MPTP). After ECoL+MPTP co-treatments, the changes of dopaminergic neurons, neural vasculature, nervous system, and locomotor activity were examined, respectively. The expressions of genes related to neurodevelopment and autophagy were detected by RT-qPCR. Further, the interaction between autophagy regulators and ECoL flavonoids was predicted using molecular docking method.ResultsAs a result, 5 kinds of flavonoid were identified in ECoL, consisting of 121 flavones and flavonols, 32 flavanones, 22 isoflavonoids, 11 chalcones and dihydrochalcones, and 17 anthocyanins. ECoL significantly ameliorated the loss of dopaminergic neurons and neural vasculature, restored the injury of nervous system, and remarkably reversed the abnormal expressions of neurodevelopment-related genes. Besides, ECoL notably inhibited the locomotor impairment in MPTP-induced PD-like zebrafish. The underlying anti-PD effect of ECoL may be implicated in activating autophagy, as ECoL significantly upregulated the expressions of genes related to autophagy, which contributes to the degradation of α-synuclein aggregation and dysfunctional mitochondria. Molecular docking simulation showed the stable interaction between autophagy regulators (Pink, Ulk2, Atg7, and Lc3b) and 10 main compounds of flavonoid in ECoL, further affirming the involvement of autophagy activation by ECoL in anti-PD action.ConclusionOur results suggested that ECoL has the anti-PD effect, and ECoL might be a promising therapeutic candidate for PD treatment.

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Effects of Medicinal Plants and Flavonoids on Parkinson's Disease, a Review on Basic and Clinical Evidences

Cited by 12 publications

References 73 publications

Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal

The alleviative effect of Calendula officinalis L. extract against Parkinson’s disease-like pathology in zebrafish via the involvement of autophagy activation

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