Effects of medicinal food plants on impaired glucose tolerance: A systematic review of randomized controlled trials

Demmers, A; Korthout, Henrie A. A. J.; Etten-Jamaludin, Faridi S. van; Kortekaas, Francesco; Maaskant, Jolanda

doi:10.1016/j.diabres.2017.05.024

Cited by 25 publications

(20 citation statements)

References 44 publications

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“…On the basis of the results of these studies, it was found that curcumin consumption exerted a positive effect on weight management of obese individuals, lowering blood lipids and improving glycemic control. This result is in line with a recent meta‐analysis, which showed that curcumin supplementation can lower plasma leptin levels (Atkin, Katsiki, Derosa, Maffioli, & Sahebkar, ), and a systematic review that documented a decrease in fasting glucose levels after 2 hr of oral glucose tolerance test, glycosylated hemoglobin levels A1c, and insulin resistance (HOMA‐IR; Demmers, Korthout, van Etten‐Jamaludin, Kortekaas, & Maaskant, ). Moreover, curcumin administration in patients suffering from various types of cancer, such as prostate, breast, pancreatic, biliary tract, and colon cancer may improve overall health, ameliorating the adverse side effects induced by common pharmaceutical regimens and, in some cases, slowing down disease progression.…”

Section: Discussionsupporting

confidence: 86%

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

Mantzorou

Pavlidou

Vasios

et al. 2018

Phytotherapy Research

108

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Numerous clinical trials have investigated the potential beneficial effects of curcumin supplementation against several human chronic diseases. Up to now, it has been claimed that curcumin consumption may exert beneficial effects against several chronic diseases by promoting human health and preventing diseases. In this aspect, the present review aims to critically collect and in-depth summarize the most recent, well-designed clinical studies evaluating the potential beneficial effects of curcumin consumption on human health promotion and disease prevention. According to recent and well-designed clinical studies, curcumin consumption may benefit against obesity, metabolic syndrome, and diabetes. Moreover, curcumin consumption seems to exert a positive effect on people suffering from various types of cancer, fatty liver disease, depression, arthritis, skin diseases, gut inflammation, and symptoms of premenstrual syndrome. Due to the strong heterogeneity among the clinical studies concerning the exact effective curcumin dose and formulation, as well as the recommended treatment duration for each chronic disease, no precise and definitive conclusions could be drawn. Further large-scale prospective studies are strongly recommended, being well-designed as far as follow-up times, dosage, formulation, and duration of curcumin supplementation are concerned. Moreover, potential confounders in each specific chronic disease should carefully be taken into account in future studies.

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Section: Discussionsupporting

confidence: 86%

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

Mantzorou

Pavlidou

Vasios

et al. 2018

Phytotherapy Research

108

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“…OGTT can simulate the postprandial hyperglycemic state, which is an effective way to investigate the effect of insulin on glucose utilization (Demmers, Korthout, Van Etten‐Jamaludin, Kortekaas, & Maaskant, 2017). The T2DM group showed intolerance to a bolus of glucose, as evidenced by a slower rate of restoration of higher blood glucose levels to normal values than the Control group (Figure 1B); the statistically significant difference in the AUC is shown in Figure 1C ( P < 0.01).…”

Section: Resultsmentioning

confidence: 99%

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Xin

Zhang

et al. 2020

Journal of Food Science

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We aimed to investigate) the effects of Aronia melanocarpa berry extract (AMBE) on hepatic insulin resistance and its mechanism at the molecular level in high-fat diet (HFD)-and streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats. The rats were supplemented with AMBE at doses of 100 and 400 mg/kg body weight (bw) daily for 8 weeks. AMBE significantly reduced blood glucose and serum insulin levels and the homeostatic model assessment for insulin resistance score; improved glucose tolerance; increased hepatic glycogen content; and regulated glucose metabolism enzyme activity, including glucokinase, pyruvate kinase, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase in the liver. AMBE also reduced lipid accumulation and oxidative stress along with inflammation in the hepatic tissue of T2DM rats and improved hepatic function. The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was activated by AMBE through the elevation of insulin receptor substrate-2, PI3K, Akt, and glycogen synthase kinase-3β phosphorylation and glucose transporter 2, which might contribute to the promotion of glycogen synthesis and improvement of hepatic insulin resistance. AMBE shows promise as an ingredient of functional foods for alleviating hepatic insulin resistance in T2DM.Keywords: Aronia melanocarpa berry, hepatic insulin resistance, PI3K/Akt signaling pathway, type 2 diabetes mellitus Practical Application: The extract from the berries of Aronia melanocarpa (Michx.) Elliott (AMBE), with its relatively high content of polyphenolic compounds, has been shown to exert hypoglycemic effects in animal models of diabetes. Our findings support the use of A. melanocarpa as a functional food additive for the alleviation of hepatic insulin resistance and the management of glucose homeostasis in T2DM.

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“…Despite the benefit of curcumin in glycemia regulation and insulin signaling through activation of a range of molecules, including hormone receptors, transcription factors, enzymes, growth factors, cytokines, and adipokines (Jiménez-Osorio et al, 2016), the effect of curcumin in humans with diabetes mellitus has not yet been completely elucidated. Although curcumin has presented efficacy in the treatment of impaired glucose tolerance, there is still insufficient evidence for its long-term use (Demmers et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…is not yet clear, and these issues have recently been identified as important research targets (Demmers et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…However, although this bioactive has aroused growing scientific interest due to its possible therapeutic effects (Jiménez-Osorio et al, 2016), the efficacy of curcumin is limited in humans owing to its low solubility and bioavailability in the organism (Derosa, Maffioli, Simental-Mendia, Bo, & Sahebkar, 2016;Jäger et al, 2014). In addition, different methodologies of human clinical trials have contributed to contradictory results of the curcumin effect on glycemic and inflammatory profiles (Demmers, Korthout, van Etten-Jamaludin, Kortekaas, & Maaskant, 2017;Derosa et al, 2016).…”

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confidence: 99%

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Influence of curcumin on glycemic profile, inflammatory markers, and oxidative stress in HIV‐infected individuals: A randomized controlled trial

Silva

Medeiros²,

Medeiros

et al. 2020

Phytotherapy Research

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To evaluate the influence of curcumin supplementation on the glycemic profile, inflammatory markers, and oxidative stress in HIV‐infected individuals under antiretroviral therapy. This double‐blind, crossover, randomized clinical trial was composed of 20 subjects arranged initially into experimental group (n = 10) and placebo group (n = 10) groups, receiving 1,000 mg curcumin/day or microcrystalline cellulose/day, respectively, during a 30‐day period and 12‐day washout. Subsequently, the groups were switched to follow the crossover design. Fasting glucose and insulin, IL‐10, tumor necrosis factor alpha, malonialdehyde, and reduced glutathione were measured. Food consumption was evaluated as a control variable. Descriptive statistics are presented as mean and standard deviation, and inferential analyses were performed from two‐way analysis of variance and the magnitude of the effect. No significant improvements were observed in the glycemic, inflammatory, or oxidative stress profiles. Although the mean serum fasting glucose levels and the homeostatic model assessment index presented qualitative improvement in the CG, this result should be interpreted with caution since the observed variation may represent acceptable fluctuation, in addition to the small difference between the means, added to the large variation observed in the standard deviation. Supplementation with curcumin in HIV‐infected individuals undergoing antiretroviral therapy and training did not improve the glycemic, inflammatory, or oxidative stress profiles.

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Effects of medicinal food plants on impaired glucose tolerance: A systematic review of randomized controlled trials

Cited by 25 publications

References 44 publications

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats

Influence of curcumin on glycemic profile, inflammatory markers, and oxidative stress in HIV‐infected individuals: A randomized controlled trial

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