Effects of medetomidine and medetomidine-butorphanol on transcranial color-coded duplex ultrasonography in healthy dogs

Duque, Javier; Dominguez-Roldan, J.M.; Martínez-Taboada, Fernando; Macías‐García, Beatriz; Rodríguez-Medina, P.; Barrera-Chacón, Rafael

doi:10.1016/j.rvsc.2013.04.010

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…Semen collection has been performed using urethral catheterization after the administration of an α 2 -adrenergic agonist in cats, but medetomidine drugs are emphasized in several studies; their effectiveness for this procedure is referenced in both domestic and wild cats. 8–24 MED is a selective α 2 -adrenergic agonist composed of the enantiomers DEX and levomedetomidine. 24 DEX is the newest and most selective α 2 -adrenergic agonist used with effects such as sedation, analgesia and anxiolysis.…”

Section: Discussionmentioning

confidence: 99%

“…MED is a potent α 2 -adrenergic agonist and plays a role in promoting sedation, analgesia and muscle relaxation. [12][13][14] Several authors have reported semen collection by ejaculation in domestic cats after the administration of this agent, using posterior urethral catheterization. 7,8,13,15 DEX is the newest and most selective α 2 -adrenergic agonist with effects such as sedation, analgesia and anxiolysis.…”

Section: Quality Of Domestic Cat Semen Collected By Urethral Catheterization After the Use Of Different Alpha 2-adrenergic Agonistsmentioning

confidence: 99%

“…[12][13][14] Several authors have reported semen collection by ejaculation in domestic cats after the administration of this agent, using posterior urethral catheterization. 7,8,13,15 DEX is the newest and most selective α 2 -adrenergic agonist with effects such as sedation, analgesia and anxiolysis. 16,17 Its efficiency as an inductor of ejaculation in domestic cats has also been demonstrated.…”

Section: Quality Of Domestic Cat Semen Collected By Urethral Catheterization After the Use Of Different Alpha 2-adrenergic Agonistsmentioning

confidence: 99%

“…12–14 Several authors have reported semen collection by ejaculation in domestic cats after the administration of this agent, using posterior urethral catheterization. 7,8,13,15…”

Section: Introductionmentioning

confidence: 99%

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Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists

Madrigal‐Valverde

Bittencourt

Filho

et al. 2020

Journal of Feline Medicine and Surgery

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Objectives We compared the effects of two alpha (α)2-adrenergic agonists on semen traits. Methods In this study, 13 adult domestic cats were divided into two experimental groups, according to the chemical ejaculation protocol used: the first group received medetomidine hydrochloride (100 µg/kg) and ketamine (5000 µg/kg); the second group received dexmedetomidine hydrochloride (25 µg/kg) and ketamine (5000 µg/kg), both by the intramuscular route. Results The animals responded positively ( P >0.05) to chemical collection. Seminal parameters evaluated included volume, sperm vigor, total motility, progressive motility, sperm concentration, and the structural and functional integrity of the plasma membrane; sperm morphology values did not differ between groups ( P >0.05). Conclusions and relevance The results indicated that dexmedetomidine is a more viable and economical alternative to medetomidine in domestic cats submitted to semen collection by urethral catheterization. Semen collection by urethral catheterization after using α2-adrenergic agonists is a recently developed technique in feline species that is considered to be quick and highly applicable to assisted reproduction programs in felids.

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Section: Discussionmentioning

confidence: 99%

Section: Quality Of Domestic Cat Semen Collected By Urethral Catheterization After the Use Of Different Alpha 2-adrenergic Agonistsmentioning

confidence: 99%

Section: Quality Of Domestic Cat Semen Collected By Urethral Catheterization After the Use Of Different Alpha 2-adrenergic Agonistsmentioning

confidence: 99%

“…12–14 Several authors have reported semen collection by ejaculation in domestic cats after the administration of this agent, using posterior urethral catheterization. 7,8,13,15…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists

Madrigal‐Valverde

Bittencourt

Filho

et al. 2020

Journal of Feline Medicine and Surgery

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“…Two α2‐adrenergic agonists are routinely used: medetomidine and dexmedetomidine. Medetomidine is known to be a potent α2‐adrenergic agonist that promotes sedation, analgesia and muscle relaxation (Duque et al, 2013; Nasrallah et al, 2014). However, its use in high doses carries the risk of cardiovascular side effects, which may make its use unfeasible in some animals (Romagnoli et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Comparison of two pharmacological semen collection times with α2‐adrenergic agonist in domestic cats

Hidalgo,

de Almeida,

dos Santos Silva

et al. 2023

Reprod Domestic Animals

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The use of α2‐adrenergic agonists in association with urethral catheterization has been used as a technique for pharmacological semen collection in cats. The mechanism of action of this drug is the stimulation of adrenoreceptors in the vas deferens, which results in ejaculation. While medetomidine is the α2‐agonist most commonly used in studies, ejaculation with the use of dexmedetomidine associated with ketamine has been effective, but with variable results. Therefore, further studies regarding the methodology of use are required to obtain better seminal quality. This study aimed to compare two pharmacological semen collection times after the association of dexmedetomidine (30 μg/kg, IM; Dormitor®, Zoetis), ketamine (5 mg/kg, IM; ketamine, Vetnil) and urethral catheterization using a tomcat probe (0.8 mm × 1.00 mm × 11 cm). The collections were divided into two experimental groups: G10 (N = 8; urethral catheterization after 10 min of anaesthesia) and G15 (N = 8; urethral catheterization after 15 min of anaesthesia). The ejaculates were evaluated for ejaculate volume, sperm concentration, morphology and kinetics using the CASA system. To compare the groups, the t‐test and the Mann–Whitney U‐test were used with a significance level of 5%. It was identified that ejaculate volume (G10: 22.62 ± 2.13 vs. G15: 26.81 ± 1.55; p < .001) and sperm concentration (G10: 48.10 × 106 ± 17.84 vs. G15: 90.18 × 106 ± 19.35; p < .001) was higher in G15 than in G10 and had a lower percentage of minor defects than G10 (G10: 3.12 ± 2.41 vs. G15: 1.00 ± 1.19; p = .043). Regarding the kinetic parameters, the results of G15 were better for total motility—TM (G10: 67.00 ± 10.33 vs. G15: 81.87 ± 7.99; p = .006) and faster cells—RAPID: (G10: 55.00 ± 16.63 vs. G15: 74.25 ± 11.94; p = .019); whereas a higher proportion of cells with slow speed—SLOW were seen in G10 (G10: 31.00 ± 12.07 vs. 17.12 ± 7.53; p = .015). Based on these findings, we suggest that collection via urethral catheterization should be performed 15 min after the application of ketamine‐associated dexmedetomidine to obtain a better‐quality ejaculate.

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POCUS: Brain – Clinical Integration

Carvalho¹

2021

Point‐of‐Care Ultrasound Techniques for the Small Animal Practitioner

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Effects of medetomidine and medetomidine-butorphanol on transcranial color-coded duplex ultrasonography in healthy dogs

Cited by 4 publications

References 32 publications

Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists

Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists

Comparison of two pharmacological semen collection times with α2‐adrenergic agonist in domestic cats

POCUS: Brain – Clinical Integration

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