Effects of mechanical stimulation of sole support zones on the H-reflex characteristics under conditions of support unloading

Zakirova, A. Z.; Shigueva, Tatiana; Tomilovskaya, Elena; Kozlovskaya, I. B.

doi:10.1134/s0362119715020176

Cited by 10 publications

(11 citation statements)

References 17 publications

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“…A decrease of transverse stiffness in m.soleus in this group reached significance only by the 6th day of DI; at the same time decrease of EMG amplitude at rest and maximal isokinetic force of m.triceps surae as well as signs of hyperreflexia and changes in MU recruitment order were not registered at all (Grigoriev et al, 2004; Khusnutdinova et al, 2004; Miller et al, 2004, 2005, 2010; Netreba et al, 2004, 2005, 2006; Kozlovskaya et al, 2007a,b; Shigueva et al, 2015a; Zakirova et al, 2015). Analogous effects of mechanical stimulation of the soles support zones were demonstrated in the structure of the muscular apparatus: no decrease of myofibrils’ sensitivity to free calcium ions, which is regularly observed under conditions of gravitational unloading; no changes in the cross sectional area of muscle fibers; and no decrease of the number of fibers containing slow isoforms of heavy myosin chains (Grigoriev et al, 2004; Moukhina et al, 2004; Shenkman et al, 2004a,b).…”

Section: Does Support Withdrawal Triggers Hypogravitational Motor Synmentioning

confidence: 95%

“…The sensitivity to proprioceptive signals was also changed: exposure to DI was associated with the development of H-reflex system hypersensitivity, which was demonstrated by a decrease of the soleus H-reflex thresholds and an increase of relative H-reflex amplitudes (Kozlovskaya et al, 2007a; Saenko, 2007; Zakirova et al, 2015).…”

Section: Effects On the Sensory-motor Systemmentioning

confidence: 99%

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Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

et al. 2019

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Dry immersion (DI) is one of the most widely used ground models of microgravity. DI accurately and rapidly reproduces most of physiological effects of short-term space flights. The model simulates such factors of space flight as lack of support, mechanical and axial unloading as well as physical inactivity. The current manuscript gathers the results of physiological studies performed from the time of the model’s development. This review describes the changes induced by DI of different duration (from few hours to 56 days) in the neuromuscular, sensory-motor, cardiorespiratory, digestive and excretory, and immune systems, as well as in the metabolism and hemodynamics. DI reproduces practically the full spectrum of changes in the body systems during the exposure to microgravity. The numerous publications from Russian researchers, which until present were mostly inaccessible for scientists from other countries are summarized in this work. These data demonstrated and validated DI as a ground-based model for simulation of physiological effects of weightlessness. The magnitude and rate of physiological changes during DI makes this method advantageous as compared with other ground-based microgravity models. The actual and potential uses of the model are discussed in the context of fundamental studies and applications for Earth medicine.

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Section: Does Support Withdrawal Triggers Hypogravitational Motor Synmentioning

confidence: 95%

Section: Effects On the Sensory-motor Systemmentioning

confidence: 99%

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

et al. 2019

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“…It is assumed that changes in the work of the CNS under conditions of support unloading may be the cause of a decrease in inhibitory effects on spinal reflexes, however, this statement remains the subject of discussion. The phenomenon of spinal hyperreflexia is observed both after SF ( Reschke et al, 1984b ; Kozlovskaya et al, 1988 ; Grigoriev and Ushakov, 2013 ) and after DI ( Zakirova et al, 2015 ; Acket et al, 2018 ). A recent study of the excitability of the motor neuron pool in the soleus and gastrocnemius muscles in terms of values of the thresholds and amplitudes of the motor response to transcranial and transspinal magnetic stimulation after DI confirms the spinal nature of the development of hypogravitational hyperreflexia.…”

Section: Dry Immersionmentioning

confidence: 99%

Impact of different ground-based microgravity models on human sensorimotor system

et al. 2023

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This review includes current and updated information about various ground-based microgravity models and their impact on the human sensorimotor system. All known models of microgravity are imperfect in a simulation of the physiological effects of microgravity but have their advantages and disadvantages. This review points out that understanding the role of gravity in motion control requires consideration of data from different environments and in various contexts. The compiled information can be helpful to researchers to effectively plan experiments using ground-based models of the effects of space flight, depending on the problem posed.

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“…Investigators found that mechanical stimulation via pressurized boots restores neuromuscular activation throughout the entirety of the lower limb musculature and leads to preserved lower limb strength and locomotor function (Layne and Forth, 2008). Similar effects of mechanical stimulation have been demonstrated during DI (Ogneva et al, 2011;Zakirova et al, 2015). Importantly, the prevention of DI-induced structural and functional changes in soleus fibers were observed only with mechanical foot stimulation and not with electrical muscle stimulation, suggesting that tactile input is more important than contractile activity for protection against gravitational unloading.…”

Section: Tactile Inputmentioning

confidence: 92%

Developing Proprioceptive Countermeasures to Mitigate Postural and Locomotor Control Deficits After Long-Duration Spaceflight

Macaulay

Peters

Wood

et al. 2021

Front. Syst. Neurosci.

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Astronauts experience post-flight disturbances in postural and locomotor control due to sensorimotor adaptations during spaceflight. These alterations may have adverse consequences if a rapid egress is required after landing. Although current exercise protocols can effectively mitigate cardiovascular and muscular deconditioning, the benefits to post-flight sensorimotor dysfunction are limited. Furthermore, some exercise capabilities like treadmill running are currently not feasible on exploration spaceflight vehicles. Thus, new in-flight operational countermeasures are needed to mitigate postural and locomotor control deficits after exploration missions. Data from spaceflight and from analog studies collectively suggest that body unloading decreases the utilization of proprioceptive input, and this adaptation strongly contributes to balance dysfunction after spaceflight. For example, on return to Earth, an astronaut’s vestibular input may be compromised by adaptation to microgravity, but their proprioceptive input is compromised by body unloading. Since proprioceptive and tactile input are important for maintaining postural control, keeping these systems tuned to respond to upright balance challenges during flight may improve functional task performance after flight through dynamic reweighting of sensory input. Novel approaches are needed to compensate for the challenges of balance training in microgravity and must be tested in a body unloading environment such as head down bed rest. Here, we review insights from the literature and provide observations from our laboratory that could inform the development of an in-flight proprioceptive countermeasure.

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Effects of mechanical stimulation of sole support zones on the H-reflex characteristics under conditions of support unloading

Cited by 10 publications

References 17 publications

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

Impact of different ground-based microgravity models on human sensorimotor system

Developing Proprioceptive Countermeasures to Mitigate Postural and Locomotor Control Deficits After Long-Duration Spaceflight

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