Effects of meal consistency and ingested fluid volume on the intragastric distribution of a drug model in humans—a magnetic resonance imaging study

Faas, Henryk; Steingoetter, Andreas; Feinle, Christine; Rades, Thomas; Lengsfeld, Hans; Boesiger, Peter; Fried, Michael; Schwizer, Werner

doi:10.1046/j.1365-2036.2002.01154.x

Cited by 36 publications

(29 citation statements)

References 14 publications

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“…However, the method is limited by the necessity to use X-rays and, thus, is not applicable for real-time measurements. To overcome the problem, more advanced techniques were developed such as the detection of plastic tablets with a metal core by use of a metal detector (15), the detection of 99m Tc-or 111 In-coated tablets by using a double-headed gamma camera (37), or even the detection of magnetic tablets by MRI (16,44,45).…”

Section: Discussionmentioning

confidence: 99%

Every slow-wave impulse is associated with motor activity of the human stomach

Hocke¹,

Schöne²,

Richert³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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Using a newly developed high-resolution three-dimensional magnetic detector system (3D-MAGMA), we observed periodical movements of a small magnetic marker in the human stomach at the typical gastric slow-wave frequency, that is 3 min(-1). Thus we hypothesized that each gastric slow wave induces a motor response that is not strong enough to be detected by conventional methods. Electrogastrographies (EGG, Medtronic, Minneapolis, MN) for measurement of gastric slow waves and 3D-MAGMA (Innovent, Jena, Germany) measurements were simultaneously performed in 21 healthy volunteers (10 men, 40.4+/-13.6 yr; 11 women, 35.8+/-11.6 yr). The 3D-MAGMA system contains 27 highly sensitive magnetic field sensors that are able to locate a magnetic pill inside a human body with an accuracy of +/-5 mm or less in position and +/-2 degrees in orientation at a frequency of 50 Hz. Gastric transit time of the magnetic marker ranged from 19 to 154 min. The mean dominant EGG frequency while the marker was in the stomach was 2.87+/-0.15 cpm. The mean dominant 3D-MAGMA frequency during this interval was nearly identical; that is, 2.85+/-0.15 movements per minute. We observed a strong linear correlation between individual dominant EGG and 3D-MAGMA frequency (R=0.66, P=0.0011). Our findings suggest that each gastric slow wave induces a minute contraction that is too small to be detected by conventional motility investigations but can be recorded by the 3D-MAGMA system. The present slow-wave theory that assumes that the slow wave is a pure electrical signal should be reconsidered.

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Section: Discussionmentioning

confidence: 99%

Every slow-wave impulse is associated with motor activity of the human stomach

Hocke¹,

Schöne²,

Richert³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Gastric emptying is so controlled that about 2 to 4 kcal/min (8.4 to 16.8 kJ/min) caloric content is delivered to the duodenum through a negative feedback mechanism mediated by the duodenal receptors. Meals with similar energy content are emptied from the stomach at similar rates (Faas and others 2002; Gentilcore and others 2006; Hellström and others 2006). In this context, meal calories, compositions, and size are important for gastric emptying.…”

Section: Gastric Digestion and Emptying Of Foodsmentioning

confidence: 99%

Disintegration of Solid Foods in Human Stomach

Kong

Singh

2008

Journal of Food Science

493

321

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Knowledge of the disintegration of solid foods in human stomach is essential to assess the bioavailability of nutrients in the gastrointestinal (GI) tract. A comprehensive review of food gastric digestion, focusing on disintegration of solid foods, is presented. Most of the research reviewed in this paper is contained in the medical, pharmaceutical, food, and nutritional literature. Stomach physiology is briefly introduced, including composition and rheological properties of gastric contents, stomach wall motility in fed/fasted states, and hydrodynamic and mechanical forces that act on the ingested food. In vivo and in vitro methods used for studying food and drug digestion in GI are summarized. Stomach emptying rate, which controls the rate of absorption of nutrients, is highly related to the disintegration of foods. This topic is highlighted with focus on the important mechanisms and the influence of chemical and physical properties of foods. Future research in this area is identified to increase our fundamental understanding of the food digestion process in the stomach as related to the food composition, material properties such as texture and microstructure, and chemical characteristics. This information is necessary to develop new guidelines for seeking innovative processing methods to manufacture foods specifically targeted for health.

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“…The use of advanced imaging technologies has recently demonstrated how the physical properties of the meal can modulate satiety and the rate of nutrient delivery to the small bowel, by simply modifying the intragastric distribution of the meal (Boulby et al, 1999;Faas et al, 2002;Kunz et al, 2005;Marciani et al, 2001Marciani et al, , 2007Marciani et al, , 2012. However, up to now little is known about the mechanisms underpinning the distribution and mixing of different digesta systems within the stomach.…”

Section: Introductionmentioning

confidence: 97%