Effects of MCI-154, a novel cardiotonic agent, on mean circulatory filling pressure in anesthetized dogs

Satoh, Naoya; Abe, Yuji; Kitada, Yoshimi; Narimatsu, Akihiro; Tobe, Akihiro

doi:10.1016/0014-2999(90)90570-v

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…We used Isoproterenol (ISO) (1-(3′,4′-dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride), a nonselective β -adrenergic agonist, which causes infarct-like necrosis of the heart muscle with subsequent leakage of cardiac enzymes in blood leading to cardiac dysfunction in rats [15–17]. Cardioprotective action of MHR was studied in ISO-challenged rats.…”

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of Polyherbal Ayurvedic Cardiotonic Preparation “Mahamrutyunjaya rasa”

Pallavi

Rajput

2010

Evidence-Based Complementary and Alternative Medicine

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Mahamrutyunjaya rasa (MHR), an Ayurvedic formulation, used as cardiotonic, contains potentially toxic compounds like aconitine, which are detoxified during preparation using traditional methods. Comparative toxicological evaluation of laboratory prepared formulation (F1) and two marketed formulations (F2 and F3) were performed based on their effects on viability of H9c2 cells and after single oral dose administration in mice. Cardioprotective effect of formulations at 25 and 50 mg/kg doses were studied in isoproterenol- (ISO-) induced myocardial infarcted rats. F1 and F2 did not affect the cell viability, while F3 decreased the cell viability in concentration and time-dependent manner. Rats administered with ISO showed significant increase in the serum levels of glutamate oxaloacetate transaminase, alkaline phosphotase, creatinine kinase isoenzymes, lactate dehydrogenase, and uric acid, while F1 and F2 treatment showed significant reduction in the same. F3 showed further increase in the serum levels of enzymes and uric acid in ISO-challenged rats. High pressure liquid chromatographic analysis of formulations showed higher concentration of aconitine in F3. Study shows that F1 and F2 possess cardioprotective property with higher safety, while formulation F3 cannot be used as cardioprotective due to its cytotoxic effects. Thus, proper quality assessment methods are required during preparation of traditional formulations.

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Section: Introductionmentioning

confidence: 99%

Biological Evaluation of Polyherbal Ayurvedic Cardiotonic Preparation “Mahamrutyunjaya rasa”

Pallavi

Rajput

2010

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Similar observations were made following oral administration. The drug also produced direct vasodilator (78) and venodilator effects (95). From these results, one can conclude that MCI-154 has well-balanced inotropic and vasodilator properties.…”

Section: Mci-154mentioning

confidence: 90%

Calcium‐Sensitizing Drugs: Positive Inotropy by Enhanced Sensitivity of the Contractile Apparatus to Calcium

Donck

1996

Cardiovascular Drug Reviews

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Improvement of postischemic contractile dysfunction of dog heart by MC1-154, a novel cardiotonic agent

Abe¹,

Kitada²,

Narimatsu³

et al. 1991

European Journal of Pharmacology

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Effects of MCI-154, a novel cardiotonic agent, on mean circulatory filling pressure in anesthetized dogs

Cited by 7 publications

References 18 publications

Biological Evaluation of Polyherbal Ayurvedic Cardiotonic Preparation “Mahamrutyunjaya rasa”

Biological Evaluation of Polyherbal Ayurvedic Cardiotonic Preparation “Mahamrutyunjaya rasa”

Calcium‐Sensitizing Drugs: Positive Inotropy by Enhanced Sensitivity of the Contractile Apparatus to Calcium

Improvement of postischemic contractile dysfunction of dog heart by MC1-154, a novel cardiotonic agent

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