Effects of Maternal Ω‐3 Supplementation on Fatty Acids and on Visual and Cognitive Development

Hurtado, José Antonio; Iznaola, C.; Peña, Maria Marjorette O.; Ruiz, Josefa; Quintana, Luis Peña; Kajarabille, Naroa; Rodriguez-Santana, Yessica; Sanjurjo, Pablo; Aldámiz‐Echevarría, Luis; Ochoa, Julio J.; Lara-Villoslada, Federico

doi:10.1097/mpg.0000000000000864

Cited by 54 publications

(53 citation statements)

References 40 publications

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“…As we have previously reported (Hurtado et al . ), our mother supplementation with omega 3 LC‐PUFA during the gestation and lactation increased the percentage of DHA and other fatty acids of the omega‐3 series in different cell compartments, both in the mother (placenta, plasma, erythrocyte membrane and milk) and in their neonates (plasma and erythrocyte membrane), reason why we have not included information about the mother or neonate fatty acids profile in the current study.…”

Section: Discussionmentioning

confidence: 93%

Omega‐3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress

Kajarabille

Hurtado

Quintana

et al. 2016

Maternal & Child Nutrition

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There is controversy about fish-oil supplementation and oxidative damage. This ambiguity should be explored to elucidate its role as modulator of oxidative stress, especially during gestation and postnatal life. This is the objective of this study. One hundred ten pregnant women were divided in two groups: control group CT (400 mL/day of the control dairy drink); supplemented group FO (400 mL/day of the fish oil-enriched dairy drink (±400-mg EPA-DHA/day)). Different biomarkers of oxidative damage were determined in the mother's at enrolment, at delivery and at 2.5 and 4 months postpartum and newborns at delivery and at 2.5 months postpartum. Omega-3 LC-PUFA supplementation during pregnancy and lactation decreased plasma hydroperoxides especially in newborn at delivery (P = 0.001) and 2.5 months (P = 0.006), increased superoxide dismutase (SOD) and catalase (CAT) in mothers at delivery (P = 0.024 (SOD)) and after 2.5 months (P = 0.040 (CAT)) and in newborns at 2.5 months (P = 0.035 (SOD); P = 0.021 (CAT)). Also, supplementation increased α-tocoferol in mothers at 2.5 months (P = 0.030) and in umbilical cord artery (P = 0.039). Higher levels of CoQ10 were found in mothers at delivery (P = 0.039) as well as in umbilical cord vein (P = 0.024) and artery (P = 0.036). Our supplementation prevents the oxidative stress in the mother and neonate during the first months of postnatal life, being a potential preventive nutritional strategy to prevent functional alterations associated with oxidative stress that have an important repercussion for the neonate development in the early postnatal life.

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Section: Discussionmentioning

confidence: 93%

Omega‐3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress

Kajarabille

Hurtado

Quintana

et al. 2016

Maternal & Child Nutrition

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“…Six studies investigated a possible association between milk levels of L-PUFAs and child mental development using the Mental Developmental Index (MDI) of the Bayley Scales of Infant and Toddler Development, which evaluates several aspects related to toddler cognitive development, including memory, habituation and problem solving, through the assignment of a score directly proportional to the quality of the toddler's performance. Half of the studies did not find a significant association between milk L-PUFAs levels and MDI scores (Hurtado et al, 2015;Jensen et al, 2005;Westerberg et al, 2011). In contrast, three studies found a significant association between high total milk fat content (Agostoni et al, 2001) or DHA milk levels (Makrides et al, 2009) and high MDI scores; and a trend for an association between high levels of ω-3 L-PUFAs and ω-3/ω-6 L-PUFAs ratio and high MDI scores (Guxens et al, 2011).…”

Section: Toddlerhood Lipidsmentioning

confidence: 89%

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Benedetto

Bottanelli

Cattaneo

et al. 2020

Brain, Behavior, and Immunity

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Perinatal psychopathologies affect more than 25% of women during and after their gestational period. These psychiatric disorders determine important biological variations in their organisms, affecting many different physiological and metabolic pathways. Of relevance, any of these changes occurring in the mother can alter the normal composition of breast milk, particularly the concentration of nutritional and inflammatory components, which play a role in child brain functioning and development. Indeed, there is evidence showing that changes in milk composition can contribute to cognitive impairments and alterations in mental abilities in children. This review aims to shed light on the unique intergenerational role played by breast milk composition, from maternal psychopathologies to child development.

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“…However, the n ‐3 PUFA, DHA and EPA levels obtained in erythrocytes membrane compare favourably to studies of n ‐3 PUFA supplementation in humans (Hurtado et al . ). Thus, final assessment of the potential therapeutic value of neonatal n ‐3 PUFA supplementation is based on physiological outcomes.…”

Section: Discussionmentioning

confidence: 97%

Consequences of maternal omega‐3 polyunsaturated fatty acid supplementation on respiratory function in rat pups

Tenorio‐Lopes

Baldy

Jochmans-Lemoine

et al. 2016

The Journal of Physiology

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Most pre-term infants present respiratory instabilities and apnoeas as a result of incomplete development of the neural circuits that control breathing. Because omega-3 polyunsaturated fatty acids (n-3 PUFA) benefit brain development, we hypothesized that n-3 PUFA supplementation (via the maternal diet) improves respiratory function in rat pups. Pups received n-3 PUFA supplementation from an enriched diet (13 g kg of n-3 PUFA) administered to the mother from birth until the experiments were performed (postnatal days 10-11). Controls received a standard diet (0.3 g kg of n-3 PUFA). Breathing was measured in intact pups at rest and during hypoxia (FiO = 0.12; 20 min) using whole body plethysmography. The duration of apnoeas induced by stimulating the laryngeal chemoreflex (LCR) was measured under anaesthesia. Lung morphology was compared between groups. Maternal n-3 PUFA supplementation effectively raised n-3 PUFA levels above control levels both in the blood and brainstem of pups. In intact, resting pups, n-3 PUFA increased the frequency and duration of apnoeas, especially in females. During hypoxia, n-3 PUFA supplemented pups hyperventilated 23% more than controls; their anapyrexic response was 1 °C less than controls. In anaesthetized pups, n-3 PUFA shortened the duration of LCR-induced apnoeas by 32%. The relative pulmonary surface area of n-3 PUFA supplemented pups was 12% higher than controls. Although n-3 PUFA supplementation augments apnoeas, there is no clear evidence of deleterious consequences on these pups. Based on the improved lung architecture and responses to respiratory challenges, this neonatal treatment appears to be beneficial to the offspring. However, further experiments are necessary to establish its overall safety.

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Effects of Maternal Ω‐3 Supplementation on Fatty Acids and on Visual and Cognitive Development

Abstract: Omega-3 LC-PUFA dietary supplement during pregnancy and lactation influenced the mother and newborn's fatty acid profile and nervonic acid content but did not show effects on visual and cognitive/psychomotor development.

Cited by 54 publications

References 40 publications

Omega‐3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress

Omega‐3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Consequences of maternal omega‐3 polyunsaturated fatty acid supplementation on respiratory function in rat pups

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