Effects of maternal separation on the neurobehavioral development of newborn Wistar rats

Farkas, József; Reglődi, Dóra; Gaszner, Balázs; Szogyi, Donat; Horváth, Gábor; Lubics, Andrea; Tamás, Andrea; Frank, Falko; Besirevic, Dario; Kiss, P.

doi:10.1016/j.brainresbull.2008.12.011

Cited by 40 publications

(30 citation statements)

References 52 publications

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“…Our present results reveal that rats exposed to prenatal stress showed only subtle positive or negative differences compared to their unstressed mates. These findings are similar to the result of our previous study where we evaluated the neurodevelopmental outcome of early postnatal stress, namely a 3-h-long maternal deprivation, which did not induce drastic changes either [34]. Interestingly, physical landmarks, such as ear and eye opening, analyzed in a PRS protocol slightly different from this study, showed no difference between PRS offspring and control pups, not even after a cross fostering procedure, suggesting that either prenatal or postnatal interventions do not exert a profound influence on certain initial physical landmarks [40,41].…”

Section: Discussionsupporting

confidence: 91%

“…Possible gender differences were also evaluated. Tests were based on previous descriptions [31,32,34]. Weight was measured daily until 3 weeks of age.…”

Section: Neurobehavioral Testingmentioning

confidence: 99%

“…It has been shown that reflex ontogeny in rodents is influenced by several factors such as undernutrition, maternal care, toxic agents, environmental enrichment, genetic background [22][23][24][25][26][27][28][29][30]. We have previously described that perinatal hypoxic and toxic injuries remarkably delay the neurobehavioral development but 3-hr-long maternal separation induces only slight changes [31][32][33][34]. Ten et al reported for the first time that short-term neuro-functional performance correlate with long-term functional deficits and suggested the predictive value of early evaluation [35].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Maternal Stress during Different Periods of Pregnancy on the Early Neurobehavioral Response of Rats

Kvarik¹,

Mammel²

2016

J Neurol Neurosci

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Section: Discussionsupporting

confidence: 91%

“…Possible gender differences were also evaluated. Tests were based on previous descriptions [31,32,34]. Weight was measured daily until 3 weeks of age.…”

Section: Neurobehavioral Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Maternal Stress during Different Periods of Pregnancy on the Early Neurobehavioral Response of Rats

Kvarik¹,

Mammel²

2016

J Neurol Neurosci

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“…Exposure to different types of toxic materials, such as excitotoxic agents, pesticides, and ethanol can also induce neural disorders [47,48,49,50]. Although many factors contribute to increased vulnerability to neuropsychiatric disorders, numerous studies have shown that postnatal stress is a major factor both in rodents [51,52,53] and humans [54,55,56]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Postnatal Enriched Environment in a Model of Parkinson’s Disease in Adult Rats

Jungling

Reglődi

Karadi

et al. 2017

IJMS

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Environmental enrichment is a widespread neuroprotective strategy during development and also in the mature nervous system. Several research groups have described that enriched environment in adult rats has an impact on the progression of Parkinson’s disease (PD). The aim of our present study was to examine the effects of early, postnatal environmental enrichment after 6-hydroxydopamine-induced (6-OHDA) lesion of the substantia nigra in adulthood. Newborn Wistar rats were divided into control and enriched groups according to their environmental conditions. For environmental enrichment, during the first five postnatal weeks animals were placed in larger cages and exposed to intensive complex stimuli. Dopaminergic cell loss, and hypokinetic and asymmetrical signs were evaluated after inducing PD with unilateral injections of 6-OHDA in three-month-old animals. Treatment with 6-OHDA led to a significant cell loss in the substantia nigra of control animals, however, postnatal enriched circumstances could rescue the dopaminergic cells. Although there was no significant difference in the percentage of surviving cells between 6-OHDA-treated control and enriched groups, the slightly less dopaminergic cell loss in the enriched group compared to control animals resulted in less severe hypokinesia. Our investigation is the first to provide evidence for the neuroprotective effect of postnatal enriched environment in PD later in life.

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“…It is possible to examine anxiety-like behavior in animal experimental models with the joint employment of different tests, such as tests for novel object recognition, sucrose consumption and fear conditioning, as well as an open-field and light-dark box test (12). These examinations can be used effectively in experiments with antidepressants (3,21).…”

mentioning

confidence: 99%

Examination of the interaction of different lighting conditions and chronic mild stress in animal model

Müller

Gal

Betlehem

et al. 2015

Acta Physiologica Hungarica

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We examined the effects of different shift work schedules and chronic mild stress (CMS) on mood using animal model. The most common international shift work schedules in nursing were applied by three groups of Wistar-rats and a control group with normal light-dark cycle. One subgroup from each group was subjected to CMS. Levels of anxiety and emotional life were evaluated in light-dark box. Differences between the groups according to independent and dependent variables were examined with one-and two-way analysis of variance, with a significance level defined at p < 0.05. Interaction of lighting regimen and CMS was proved to be significant according to time spent in the light compartment and the average number of changes between the light and dark compartments. Results of our examination confirm that the changes of lighting conditions evocate anxiety more prominently than CMS. No significant differences were found between the results of the low rotating group and the control group, supposing that this schedule is the least harmful to health. Our results on the association between the use of lighting regimens and the level of CMS provide evidence that the fast rotating shift work schedule puts the heaviest load on the organism of animals.

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Effects of maternal separation on the neurobehavioral development of newborn Wistar rats

Cited by 40 publications

References 52 publications

Effects of Maternal Stress during Different Periods of Pregnancy on the Early Neurobehavioral Response of Rats

Effects of Maternal Stress during Different Periods of Pregnancy on the Early Neurobehavioral Response of Rats

Effects of Postnatal Enriched Environment in a Model of Parkinson’s Disease in Adult Rats

Examination of the interaction of different lighting conditions and chronic mild stress in animal model

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