Effects of Maternal Progesterone Supplementation on Fetal, Placental and Corpus Luteal Weights in the Rat

Bartholomeusz, R. K.; Bruce, Neville

doi:10.1095/biolreprod15.1.84

Cited by 24 publications

(12 citation statements)

References 8 publications

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“…It is reassuring that studies in rats and monkeys have not shown an increased rate of progesterone-related congenital anomalies (54). More importantly, a collaborative study from West Germany, which included 186 progesteroneexposed pregnancies, could not find an increase in birth defects with progesterone (55).…”

Section: Progesteronementioning

confidence: 98%

Drugs in infertility and fetal safety

Elizur

Tulandi

2008

Fertility and Sterility

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Section: Progesteronementioning

confidence: 98%

Drugs in infertility and fetal safety

Elizur

Tulandi

2008

Fertility and Sterility

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“…The increased size of the placentae results principally from cellular hyperplasia rather than hypertrophy, with little or no change in protein: DNA and RNA: DNA ratios (Butterstein and Leathem 1970). Administration of progesterone and/or oestrogens to intact pregnant rats fails to elicit placental overgrowth (Butterstein and Leathem 1972;Bartholomeusz and Bruce 1976). Yochim andZarrow (1961} and have reported that placental overgrowth in ovariectomized rats is accompanied by small but significant increases in foetal weight, but Callard and Leathem (1971) did not observe any associated increases in foetal growth.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ovarian Hormones on Foetal and Placental Growth in the Mouse

Miller¹

1978

Aust. Jnl. Of Bio. Sci.

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The effects of ovariectomy and treatment with progesterone and oestradiol on foetal and placental growth were examined. The occurrence of cellular hypertrophy and hyperplasia in the placenta in response to treatments was determined by measuring protein, DNA and RNA: DNA ratios. In control mice, which had not been ovariectomized, the daily administration of O·01-2' 56 J1g oestradiol on days 10-15 of pregnancy caused only small decreases in the number of live foetuses and foetal and placental weights on day 16. When mice were ovariectomized on day 10, gestation was maintained by administering 5 mg progesterone daily, but terminated when only 1 mg progesterone was given daily. However, when ovariectomized mice receiving 1 mg progesterone were also given O'OlJ1g oestradiol on days 10-15, gestation was maintained and the number of live foetuses and foetal and placental weights on day 16 were normal. Increasing the daily dose of oestradiol up to 2· 56J1g in mice receiving 1 mg progesterone on days 10-15 had no effect on foetal and placental growth. In contrast, the daily administration of 0·64-2· 56J1g oestradiol to ovariectomized mice receiving 5 mg progesterone on days 10-15 terminated gestation in some mice and considerably reduced the number of live foetuses and foetal and placental weights in those mice which remained pregnant on day 16.None of the treatments increased protein, DNA or the RNA : DNA ratio in the placenta to levels above those seen in control mice. The results are discussed in relation to ovariectomy-induced placental overgrowth in the rat.

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“…However, exogenous progesterone caused significant ovarian weight loss compared to control and nicotine-treated groups. The exogenous progesterone could have suppressed the corpus luteum in producing endogenous progesterone via a negative feedback mechanism as suggested in ewes [46] but not in rats [47].…”

Section: Discussionmentioning

confidence: 99%

“…Since progesterone is important in maintaining proliferation, hypertrophy and differentiation of uterine stromal cells [25], an appropriate level of progesterone is essential to initiate and maintain endometrial decidual growth. Studies also showed that a wide range of progesterone levels in the maternal plasma of a pregnant rat would not affect placental growth, embryonic survival and fetal growth [26][27][28]. In ovariectomized rats, treatment with various doses of progesterone only produced submaximal decidual growth, but when estrone was added with the progesterone, the degree of decidualization was almost the same as the control [29].…”

Section: Discussionmentioning

confidence: 99%

Nicotine and endometrial decidual growth in pseudopregnant rats

Norashikin

Ghosh

Chatterjee

et al. 2014

Reprod Medicine & Biology

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Purpose The present study aims to investigate the effects of nicotine on the endometrial decidual growth and levels of estrogen and progesterone in pseudopregnant rats. Methods Pseudopregnancy (pc) was induced in cyclic Sprague-Dawley rats by sterile mating. Subcutaneous injection of nicotine tartrate (7.5 mg/kg/day) was scheduled from day 1 through day 5, day 5 through day 9 or day 1 through day 9 of pc. In another group of pseudopregnant rats, concomitant treatment of nicotine tartrate concurrently with progesterone (2 mg/day) was scheduled from day 1 through day 9 pc. Control groups received subcutaneous injections of vehicle only. Endometrial decidualization was induced on day 5 pc. On day 10 pc, animals were sacrificed.The degree of decidual growth and circulating levels of estrogen and progesterone were measured. Results The decidual growth in all the first three nicotinetreated groups of animals was significantly reduced, particularly in the animals treated with nicotine from day 1 through day 9 pc. Plasma estrogen levels were significantly elevated in animals treated with nicotine from day 1 through day 9 pc. Conversely, levels of plasma progesterone were found to be significantly attenuated in the same group of nicotine-treated animals compared to controls. Exogenous replacement of progesterone, however, caused a higher degree of endometrial decidualization compared to the nicotine-treated group but it was slightly less than when compared to control. ConclusionsIn conclusion, nicotine-induced progesterone deficiency with a corresponding elevation of estrogen may possibly attenuate the degree of endometrial decidualization in pseudopregnant rats.

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Effects of Maternal Progesterone Supplementation on Fetal, Placental and Corpus Luteal Weights in the Rat

Cited by 24 publications

References 8 publications

Drugs in infertility and fetal safety

Drugs in infertility and fetal safety

Effects of Ovarian Hormones on Foetal and Placental Growth in the Mouse

Nicotine and endometrial decidual growth in pseudopregnant rats

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