Effects of maternal methyl donor on the pork characteristics of offspring pigs with prenatal exposure to bisphenol A

Zhuo, Yong; Wang, J.; Liu, H.; Mou, Daolin; Adebowale, Tolulope; Che, Lianqiang; Fang, Zhengfeng; Xu, Shengyu; Liu, Guilin; Al-Dhabi, Naïf Abdullah; Li, J.; Duraipandiyan, Veeramuthu; Wu, De

doi:10.1017/s175173111700252x

Cited by 10 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results indicated that maternal Met supplementation contributed to increased meat production. This effect on improved growth performance was also found in pigs ( Zhuo et al., 2018 ). Methionine is crucial to amino acid metabolism and muscle growth ( Hickling et al., 1990 ), and the coated Met is better absorbed ( Lu et al., 2014 ); therefore, the BW and muscle yield may be more sensitive to coated Met.…”

Section: Discussionsupporting

confidence: 63%

See 1 more Smart Citation

Maternal dietary methionine supplementation influences egg production and the growth performance and meat quality of the offspring

et al. 2020

View full text Add to dashboard Cite

This study aimed to investigate the effects of maternal dietary coated methionine ( Met ) on egg production and the quality, growth performance, carcass traits, and meat quality of the offspring. In total, 288 female Ross parental chickens were randomly assigned to 3 groups with 3 replicates of 32 chickens each. From week 37 to 46, the hens of different groups were fed diets containing low (0.27% Met), adequate (0.27% Met + 0.1% coated Met) ( AM ), and high (0.27% Met + 0.2% coated Met) ( HM ) Met. There was a positive response in laying rate and albumen weight in AM and HM groups. For the offspring at market age, BW, eviscerated weight, and muscle weight were increased in the AM group ( P < 0.05), whereas excessive supplementation was proven to be negative with those traits. The meat quality (color, pH, and shear force) of breast muscle was significantly influenced by different supplementation levels. The lightness and yellowness were increased in the HM group ( P < 0.05, P < 0.01, respectively), and redness was decreased in the AM group ( P < 0.05). A lower pH value occurred in chickens of the HM group ( P < 0.05). The expressions of meat quality–related genes were altered in the supplementation groups. The pH-related genes PRDX4 and PRKAG2 were found to be significantly differentially expressed ( P < 0.05, P < 0.01, respectively) and consistent with pH changes. The meat color–related gene BCO1 was also differentially expressed ( P < 0.01) and showed a corresponding change with yellowness value. Collectively, the best production performance was in the offspring with 0.1% coated Met supplementation (AM group). Supplementation with 0.2% coated Met (HM group) seemed to be excessive, but laying rate was increased in the HM group. Both results of phenotypic measurements and gene expression demonstrated that maternal-coated Met supplementation resulted in fluctuation of some meat quality indices in the offspring, but all values were still within the range found in normal chickens.

show abstract

Section: Discussionsupporting

confidence: 63%

“…However, it remains unclear whether the effects of dietary Met supplementation could be transmitted to the next generation. In pigs, maternal dietary Met supplementation was proven to affect growth performance and meat quality in offsprings ( Zhuo et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Maternal dietary methionine supplementation influences egg production and the growth performance and meat quality of the offspring

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To date, the effect of maternal MET exposure during gestation on the growth performance of pig offspring has been controversial. However, maternal nutrition during pregnancy has been found to affect offspring development and has a profound effect throughout the life of the offspring via epigenetic modifications (28,29). Thus, we speculate that the main reason for the different results is the different types and doses of MET.…”

Section: Discussionmentioning

confidence: 84%

Maternal Methyl-Donor Micronutrient Supplementation During Pregnancy Promotes Skeletal Muscle Differentiation and Maturity in Newborn and Weaning Pigs

Zou

et al. 2020

Front. Nutr.

View full text Add to dashboard Cite

Adequate maternal methyl-donor micronutrient (MET) intake is an important determinant of the organ development and metabolic renovation of offspring. The mechanism involved in skeletal myogenesis and the effect of MET supplementation during pregnancy on the maternal body remain unclear. Thus, this study aimed to investigate the potential effect of methyl donor micronutrients (MET) on skeletal muscle development and metabolism in offspring using pig models. Forty-three Duroc × Erhualian gilts were assigned to two dietary groups during gestation: control diet (CON) and CON diet supplemented with MET (folic acid, methionine, choline, vitamin B6, and vitamin B12). The results showed that maternal MET exposure during pregnancy significantly increased the concentrations of protein, triiodothyronine (T3), and thyroxine (T4) in colostrum and methyl metabolites, including S-adenosylmethionine (SAM), S-adenosyl-L-homocysteine (SAH), 5-methyl-tetrahydrofolate (5-MTHF), and betaine, in the maternal and offspring umbilical vein serum. A similar pattern was demonstrated in the body weight gain and myofiber diameters in offspring. In addition, maternal MET supplementation significantly increased the concentration of offspring serum insulin-like growth factor 1 (IGF-1), T3, and T4; upregulated the mRNA expression of IGF-1 and IGF-1 receptor (IGF-1r) and the phosphorylation level of protein kinases in offspring longissimus dorsi muscle; and upregulated the expression of myogenic genes and fast myosin heavy chain (fast MyHC) in offspring skeletal muscle. Supplementing sows with higher levels of MET during gestation may promote skeletal muscle differentiation and maturity and improve the skeletal muscle mass of the piglets.

show abstract

“…In the present study, we found that dietary MET supplementation during gestation and lactation reduced muscle GP, glycogen and glucose and glucose‐6‐P contents of finishing pigs. The results of our previous studies suggested the reduced levels of CGI‐methylation at the GS promoter persisted throughout the life of the offspring with MET during gestation and persistently silence the muscle GS gene, which is the rate‐limiting factor of glycogen deposition, thereby leading to altered glycogen deposition in later life . Meanwhile, significant differences in ultimate pH 24h values were found in the LD muscle of the MET treatment groups.…”

Section: Discussionmentioning

confidence: 94%

“…Betaine, choline, folate, methionine, etc., have been used conventionally as MET due to their biological roles of DNA methylation, improved antioxidative activities, decreased lipogenic enzymes activities and increased hormone‐sensitive lipase activity in adipose tissue . Our previous data showed that gestational diets supplemented with MET lowered plasma homocysteine (Hcy) concentrations of sows improved the antioxidant capacity of sows and newborn piglets, and affected DNA methylation of the muscle glycogen synthase and lactate dehydrogenase genes of newborn piglets and finishing pigs . Some studies have reported favorable effects of maternal MET dietary supplementation on reproduction performance, whereas others found no benefits .…”

Section: Introductionmentioning

confidence: 99%

Effect of maternal or post‐weaning methyl donor supplementation on growth performance, carcass traits, and meat quality of pig offspring

et al. 2018

View full text Add to dashboard Cite

BACKGROUND: Limited studies have examined links between maternal methyl donor (MET) supplementation and the growth-development characteristics of offspring, and possible underlying mechanisms for such links. This study investigated the effect of maternal or post-weaning MET-supplementation on growth performance, carcass characteristics, and meat quality of the finishing (d 180) offspring. Twenty-four sows were placed on a control (C) or MET-supplemented diet during pregnancy and lactation. Forty-eight female offspring were fed the control or MET-supplemented diet from weaning to 6 months of age, resulting in four study groups (six litters per group): C/C, C/MET, MET/C, and MET/MET. RESULTS: Maternal MET-supplementation increased average daily gain (ADG), body weight (BW), lean percentage and longissimus dorsi (LD) of the offspring at day 180 (P < 0.05), and upregulated the myosin heavy chain IIx, myogenic differentiation and muscle regulatory factor 4 mRNA levels in the LD muscle (P < 0.05). Meanwhile, offspring from maternal MET-supplementation exhibited a higher pH 24h post mortem and superoxide dismutase activity, a lower L * 45min , glycolytic potential, malonaldehyde content in the LD muscle, and plasma homocysteine concentration (P < 0.05). CONCLUSION: Maternal MET-supplementation has a remarkable effect on growth performance, carcass traits, and meat quality of the offspring, which is associated with increased expression levels of myogenic genes and anti-oxidant capacity.

show abstract

Effects of maternal methyl donor on the pork characteristics of offspring pigs with prenatal exposure to bisphenol A

Cited by 10 publications

References 34 publications

Maternal dietary methionine supplementation influences egg production and the growth performance and meat quality of the offspring

Maternal dietary methionine supplementation influences egg production and the growth performance and meat quality of the offspring

Maternal Methyl-Donor Micronutrient Supplementation During Pregnancy Promotes Skeletal Muscle Differentiation and Maturity in Newborn and Weaning Pigs

Effect of maternal or post‐weaning methyl donor supplementation on growth performance, carcass traits, and meat quality of pig offspring

Contact Info

Product

Resources

About