Effects of maternal lead exposure on functional plasticity in the visual cortex and hippocampus of immature rats

Altmann, L; Gutowski, Martin; Wiegand, Herbert

doi:10.1016/0165-3806(94)90067-1

Cited by 36 publications

(8 citation statements)

References 39 publications

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“…Early life exposure to Pb has been associated with a significant deterioration in cognitive abilities, an increase in instances of childhood delinquency and an enhanced susceptibility to neurodegenerative disorders. [1][2][3] The placenta does not provide an effective barrier against Pb. 4,5 Therefore, maternal exposure remains a significant source of exposure to the fetus.…”

Section: Introductionmentioning

confidence: 99%

Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

et al. 2015

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“…Early life exposure to Pb alters underlying mechanisms responsible for biological processes regulating neuronal plasticity, sexual maturity and immune functions [6–8]. This may contribute to developmental defects such as low intelligence quotient (IQ) test scores, cognitive impairment, increased likelihood of childhood delinquency and compromised ability to combat infections.…”

mentioning

confidence: 99%

Early Life Lead Exposure Causes Gender-Specific Changes in the DNA Methylation Profile of DNA Extracted from Dried Blood Spots

et al. 2015

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Aims In this paper, we tested the hypothesis that early life lead (Pb) exposure associated DNA methylation (5mC) changes are dependent on the sex of the child and can serve as biomarkers for Pb exposure. Methods In this pilot study, we measured the 5mC profiles of DNA extracted from dried blood spots (DBS) in a cohort of 43 children (25 males and 18 females; ages from 3 months to 5 years) from Detroit. Result & Discussion We found that the effect of Pb-exposure on the 5-mC profiles can be separated into three subtypes: affected methylation loci which are conserved irrespective of the sex of the child (conserved); affected methylation loci unique to males (male-specific); and affected methylation loci unique to females (female-specific).

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“…Arrowhead indicates the lack of a chlorine value because of the detection limit of the X-ray detector. the housefly's brain might also result from the diminished metabolism and low protein/neurotransmitter synthesis in neurons (Altman et al, 1994;Morley et al, 2003). In muscles, in turn, there is no barrier between the flight muscle fibers and haemolymph, so that ionic exchanges as well as chemical interactions take place over the entire surface of muscle cells.…”

Section: Elemental Changesmentioning

confidence: 99%

Elemental changes in the brain, muscle, and gut cells of the housefly, Musca domestica, exposed to heavy metals

Tylko¹,

Banach²,

Borowska³

et al. 2005

Microscopy Res & Technique

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The toxic effects of heavy metals on organisms are well established. However, their specific action at the cellular level in different tissues is mostly unknown. We have used the housefly, Musca domestica, as a model organism to study the toxicity of four heavy metals: copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb). These have been fed to larvae at low and high, semi-lethal concentrations, and their accumulation in the head, thorax, and abdomen was subsequently measured in adult flies. In addition, their impact on the cellular concentration of several elements important for cell metabolism-sodium (Na+), magnesium (Mg++), phosphorous (P), sulphur (S), chloride (Cl-) and potassium (K+)-were measured in neural cells, muscle fibers, and midgut epithelial cells. Our study showed that the heavy metals accumulate mainly in the abdomen, in which the concentrations of two of the xenobiotic metals, Cd and Pb, were 213 and 23 times more concentrated, respectively, than in controls. All the heavy metals affected the cellular concentration of light elements in all cell types, but the changes observed were dependent on tissue type and were specific for each heavy metal, and its concentration.

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Effects of maternal lead exposure on functional plasticity in the visual cortex and hippocampus of immature rats

Cited by 36 publications

References 39 publications

Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

Early Life Lead Exposure Causes Gender-Specific Changes in the DNA Methylation Profile of DNA Extracted from Dried Blood Spots

Elemental changes in the brain, muscle, and gut cells of the housefly, Musca domestica, exposed to heavy metals

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