Effects of maternal immobilization stress on birth weight and glucose homeostasis in the offspring

D’mello, Anil P.; Liu, Ying

doi:10.1016/j.psyneuen.2005.10.003

Cited by 31 publications

(29 citation statements)

References 53 publications

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“…This suggests that altered expression of Npy and Pomc are likely a consequence of increased body weight in these rats. The effects of PNS on glucose homeostasis in chow-fed rats are contradictory, where some studies find no differences on this diet (8,21), others report hyperglycemia in PNS offspring (9). In our study, we only observed hyperglycemia on the standard chow diet in the passively coping PNS rats.…”

Section: Discussioncontrasting

confidence: 61%

Prenatal Stress and Stress Coping Style Interact to Predict Metabolic Risk in Male Rats

et al. 2014

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Both prenatal stress (PNS) exposure and a passive stress-coping style have been identified as risk factors for insulin resistance in rats. In the current study, we test the hypothesis that PNS and stress-coping style may interact in predicting susceptibility for metabolic disease. To test this hypothesis, adult male control and PNS offspring were behaviorally characterized using a defensive burying test to have either a passive or proactive stress-coping style. In adulthood, all rats were fed either a standard chow or a high-fat diet for 3 weeks. After 3 weeks of diet exposure, glucose and insulin levels were assessed during an oral glucose tolerance test. Under high-fat diet conditions, PNS rats display elevated glucose and insulin responses to the oral glucose tolerance test, indicative of glucose intolerance. Interestingly, these effects of PNS were far more pronounced in rats characterized by a passive stress-coping style. Additionally, the passively coping PNS rats also gained more weight on the high-fat diet than all other rats tested. This observation suggests that a stressful prenatal environment in combination with a passive stress-coping strategy may prime an individual to be sensitive to diet-induced obesity and type 2 diabetes.

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Section: Discussioncontrasting

confidence: 61%

Prenatal Stress and Stress Coping Style Interact to Predict Metabolic Risk in Male Rats

et al. 2014

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“…Some studies indicated that prenatal stress is capable of producing a reduction in birth weight, suggesting intrauterine growth retardation 36. While others reported that there were no weight changes in prenatal stress offspring 37. The present studies showed that there was no significant difference in body weight changes among the control, stress, and stress/chewing groups.…”

Section: Discussionsupporting

confidence: 40%

Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring

Chen¹,

Ogura²,

Kondo³

et al. 2017

Int. J. Med. Sci.

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Chronic psychological stress is a risk factor for osteoporosis. Maternal active mastication during prenatal stress attenuates stress response. The aim of this study is to test the hypothesis that maternal active mastication influences the effect of prenatal stress on bone mass and bone microstructure in adult offspring. Pregnant ddY mice were randomly divided into control, stress, and stress/chewing groups. Mice in the stress and stress/chewing groups were placed in a ventilated restraint tube for 45 minutes, 3 times a day, and was initiated on day 12 of gestation and continued until delivery. Mice in the stress/chewing group were allowed to chew a wooden stick during the restraint stress period. The bone response of 5-month-old male offspring was evaluated using quantitative micro-CT, bone histomorphometry, and biochemical markers. Prenatal stress resulted in significant decrease of trabecular bone mass in both vertebra and distal femur of the offspring. Maternal active mastication during prenatal stress attenuated the reduced bone formation and increased bone resorption, improved the lower trabecular bone volume and bone microstructural deterioration induced by prenatal stress in the offspring. These findings indicate that maternal active mastication during prenatal stress can ameliorate prenatal stress-induced lower bone mass of the vertebra and femur in adult offspring. Active mastication during prenatal stress in dams could be an effective coping strategy to prevent lower bone mass in their offspring.

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“…Although many studies have reported prenatal stress-induced reduction in birth weight (9,25,34,40), few studies have also reported no change (5,16) or increase in birth weight (42). The difference in the stress protocol (type of stressor, intensity, and the timing of the stress procedure) could explain the disparity in findings between studies.…”

Section: Discussionmentioning

confidence: 96%

Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats

Balasubramanian¹,

Varde²,

Abdallah

et al. 2015

American Journal of Physiology-Endocrinology and Metabolism

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Balasubramanian P, Varde PA, Abdallah SL, Najjar SM, MohanKumar PS, MohanKumar SM. Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietaryresistant rats. Am J Physiol Endocrinol Metab 309: E582-E588, 2015. First published July 28, 2015; doi:10.1152/ajpendo.00167.2015.-Stress during pregnancy is a known contributing factor for the development of obesity in the offspring. Since maternal obesity is on the rise, we wanted to identify the effects of prenatal stress in the offspring of diet-induced obese (DIO) rats and compare them with the offspring of dietaryresistant (DR) rats. We hypothesized that prenatal stress would make both DIO and DR offspring susceptible to obesity, but the effect would be more pronounced in DIO rats. Pregnant DIO and DR rats were divided into two groups: nonstressed controls (control) and prenatal stress (subjected to restraint stress, three times/day from days 14 to 21 of gestation). After recording birth weight and weaning weight, male offspring were weaned onto a chow diet for 9 wk and shifted to a high-fat (HF) diet for 1 wk. At the end of the 10th wk the animals were euthanized, and visceral adipose mass, blood glucose, serum insulin, and C-peptide levels were measured. Prenatal stress resulted in hyperinsulinemia and higher C-peptide levels without altering caloric intake, body weight gain, or fat mass in the DIO offspring after 1 wk of HF intake, but not in DR offspring. To determine the mechanism underlying the hyperinsulinemia, we measured the levels of CEACAM1 that are responsible for insulin clearance. CEACAM1 levels in the liver were reduced in prenatally stressed DIO offspring after the HF challenge, suggesting that preexisting genetic predisposition in combination with prenatal stress increases the risk for obesity in adulthood, especially when offspring are fed a HF diet. diet-induced obese; dietary resistant; hyperinsulinemia; fetal programming; carcinoembryonic antigen-related cell adhesion molecule 1 OBESITY IS ONE OF THE MAJOR HEALTH ISSUES that has worldwide prevalence (1). In addition to genetic and lifestyle factors, growing evidence suggests that prenatal conditions could also contribute to the development of obesity in the offspring. According to Barker's hypothesis, compromised in utero conditions can induce permanent alterations in tissue structure and function of the developing fetus and increase their susceptibility to diseases like obesity and diabetes in adult life (2,17).Several studies have shown that offspring of dams placed on low-protein diets or subjected to caloric restriction have low birth weight. These offspring subsequently undergo catchup growth that places them at higher risk for obesity, hypertension, and diabetes in adulthood (18,24,32). Apart from nutritional challenges, maternal stress that increases circulating glucocorticoids during pregnancy is also known to program the offspring for metabolic diseases (12,37,38). In humans, prenatal stress in the form of maternal bereavement or natural disasters d...

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Effects of maternal immobilization stress on birth weight and glucose homeostasis in the offspring

Cited by 31 publications

References 53 publications

Prenatal Stress and Stress Coping Style Interact to Predict Metabolic Risk in Male Rats

Prenatal Stress and Stress Coping Style Interact to Predict Metabolic Risk in Male Rats

Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring

Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats

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