Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018

Abstract

Objective Hepatitis B virus infection is a major social and economic burden in developing countries, especially in China. We aimed to evaluate the effects of hepatitis B surface antigen (HBsAg) positive status on the pregnancy outcomes in the Chinese population. Methods This retrospective cohort study was performed using data from the Medical Birth Registry of Xiamen, China, from January 2011 to March 2018. Multivariate logistic regression analysis was used to assess the association between the HBsAg status and pregnancy outcomes. Results This study included 3,789 HBsAg-positive women and 29, 648 non-exposed women. The HBsAg-positive pregnant women were slightly older in age (29.3±4.3 vs. 28.9±4.4, P< 0.001). Additionally, pregnant women with a positive HBsAg status had higher odds of gestational diabetes mellitus (GDM) (adjusted odds ratio [aOR], 1.13; 95% confidence interval [CI], 1.03-1.23), and cesarean delivery (aOR, 1.12; 95%CI, 1.03-1.21). The risk of infants being large or small-for-gestational age, having low-birth weight, and of macrosomia, preterm birth, and stillbirth did not differ significantly between the HBsAg-positive and-negative women. Conclusion In Xiamen, China, the slightly higher risk of GDM and cesarean section in women positive for HBsAg should not be neglected. Further studies should be conducted to evaluate the effects of HBsAg positivity on the pregnancy outcomes in different ethnic populations.

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

“…Thirty eligible articles concerning the effect of HBV infection on pregnancy complications were included to assess the effects of HBV on preterm birth 14–17,19–25,27,28,30–38,40–47 . The results revealed significantly higher rates of preterm birth among HBV+ women compared to HBV− women ( p < 0.01) [OR (95% CI) = 1.26 (1.14–1.40)].…”

Pregnancy complicated with hepatitis B virus infection and preterm birth: a retrospective cohort study

“…There is still some controversy about the relationship between HBV infection and PTB in China and worldwide [ 8 – 10 ]. Jue Liu et al studied 489,965 pregnant women through a national cohort study and found that HBsAg positive patients increase the risk of premature delivery.…”

Prevalence of Hepatitis B Virus Among Pregnant Women on Antenatal Care Follow-Up at Mizan-Tepi University Teaching Hospital and Mizan Health Center, Southwest Ethiopia

“…1 , 6 Thus, prevention of mother-to-child transmission is an essential step in reducing the global burden of chronic HBV. 5 Although there are inconsistencies, studies have reported that maternal HBV infection is associated with preterm birth, 7 miscarriage, 8 gestational diabetes mellitus, 9 , 10 pregnancy-induced hypertension and preeclampsia. 11 …”

“…1,6 Thus, prevention of mother-to-child transmission is an essential step in reducing the global burden of chronic HBV. 5 Although there are inconsistencies, studies have reported that maternal HBV infection is associated with preterm birth, 7 miscarriage, 8 gestational diabetes mellitus, 9,10 pregnancy-induced hypertension and preeclampsia. 11 The prevalence of HBV infection among pregnant women and its associated factors varies across studies [12][13][14][15][16][17] and therefore studies from different settings are crucial to precisely measure the burden of the problem, and to make informed decisions.…”