Effects of maternal folic acid supplementation during pregnancy on infant neurodevelopment at 1 month of age: a birth cohort study in China

Yan, Jing; Zhu, Yun; Cao, Lujia; Liu, Yuyan; Zheng, Youli; Wen, Li Ming; Huang, Guowei

doi:10.1007/s00394-019-01986-7

Cited by 10 publications

(8 citation statements)

References 45 publications

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“…With many of the included studies statistically underpowered to detect statistically significant effects that are small‐to‐medium in size, it was perhaps unsurprising to note that most included studies—while providing an indication of directional associations—did not reach statistical significance. Among these maternal immune studies, three studies did include large sample sizes (>1000), which may provide insights not attenuated by sample size (Irwin et al., 2019 , Monthe‐Dreze et al., 2019 , Yan et al., 2020 ). Even among these large‐scale studies, many of the observed effects were small and/or nonsignificant.…”

Section: Resultsmentioning

confidence: 99%

Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review

Mancini

Brook

Hernández

et al. 2023

Developmental Psychobiology

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The aim of this review was to map the literature assessing associations between maternal or infant immune or gut microbiome biomarkers and child neurodevelopmental outcomes within the first 5 years of life. We conducted a PRISMA-ScR compliant review of peer-reviewed, English-language journal articles. Studies reporting gut microbiome or immune system biomarkers and child neurodevelopmental outcomes prior to 5 years were eligible. Sixty-nine of 23,495 retrieved studies were included. Of these, 18 reported on the maternal immune system, 40 on the infant immune system, and 13 on the infant gut microbiome. No studies examined the maternal microbiome, and only one study examined biomarkers from both the immune system and the gut microbiome. Additionally, only one study included both maternal and infant biomarkers. Neurodevelopmental outcomes were assessed from 6 days to 5 years. Associations between biomarkers and neurodevelopmental outcomes were largely nonsignificant and small in effect size. While the immune system and gut microbiome are thought to have interactive impacts on the developing brain, there remains a paucity of published studies that report biomarkers from both systems and associations with child development outcomes. Heterogeneity of research designs and methodologies may also contribute to inconsistent findings. Future studies should integrate data across biological systems to generate novel insights into the biological underpinnings of early development.

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Section: Resultsmentioning

confidence: 99%

Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review

Mancini

Brook

Hernández

et al. 2023

Developmental Psychobiology

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“…Age Range of Children: The age range of children in these studies varied, primarily falling between one month to eight years. Specific examples include Yan et al (22), focusing on onemonth-old infants, and Abel et al (13) and Freitas-Vilela et al (23), extending their research to include children up to 8 years.…”

Section: Studymentioning

confidence: 99%

“…Focused Areas of Research: The primary emphasis of the included studies was on the interrelation between maternal diet or nutrition during pregnancy and its subsequent effects on child neurodevelopment. In the publications we have examined, the effects on offspring neurodevelopment from the maternal intake or status of polyunsaturated fatty acids (PU-FAs) (11,18,24,25), folate (22,26,27), vitamin D (28,29), iodine (13,16,30), and iron ( 14) have been studied. Several studies have assessed the impact of the mother's dietary pattern (15,20,23), her BMI (12,17,19,31,32), and microbiota (12).…”

Section: Studymentioning

confidence: 99%

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Impact of Maternal Nutrition on Child Neurodevelopment: Insights from Recent Studies

Chamova,

Toneva,

Brajkova

et al. 2023

Biomedical Reviews

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Background:The initial 1000 days of human life, from conception to two years of age, are crucial for health growth and neuropsychological development. This period's primary environmental influence is maternal nutrition, which significantly impacts the development of the fetal nervous system. Objectives: This review aims to synthesize current literature on the effects of dietary patterns and nutritional status of pregnant women on the neurodevelopment of their offspring. Methods: Adhering to the Scale for the Quality Assessment of Narrative Review Articles (SANRA) and elements of the PRISMA guidelines, we conducted a systematic literature search in electronic databases including PubMed, Scopus, and Mendeley, focusing on publications from 2018 to 2023. Results: Our review encapsulates findings from 25 peer-reviewed articles, highlighting the influence of various nutrients like polyunsaturated fatty acids (PUFAs), vitamin D, folate, iodine, and iron on child neurodevelopment. Studies also examined the effects of maternal dietary patterns, body mass index (BMI), and alcohol exposure. Key findings indicate the crucial role of balanced maternal nutrition in optimal neurodevelopmental outcomes in children. Discussion: The review reveals intricate relationships between maternal dietary habits, supplementation, and child growth and neurological development. While some nutrients show clear benefits, others present mixed findings, underlining the complexity of maternal nutrition's role in child development. Conclusion:The review underscores the importance of balanced maternal nutrition for favorable neurodevelopmental outcomes in offspring, calling for more detailed research to understand the nuanced roles of specific nutrients and dietary patterns. Biomed Rev 2023; 34: 109-119

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“…Folate, a crucial cofactor of one-carbon unit metabolism, has been proven to be tightly associated with fetal brain formation and development due to its critical functions in the proliferation and growth of nerve cells and the synthesis of neurotransmitters [ 1 , 2 ]. Human data showed maternal folate concentration positively associated with fetal head growth and neurobehavioral development in the offspring [ 3 , 4 ]. In rodents, maternal folate deficiency may induce increased homocysteine (Hcy) transfer to the fetus, inhibit progenitor cell proliferation, increase apoptosis in the fetal forebrain, and persistently impair memory ability in offspring [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Parental Folate Deficiency Inhibits Proliferation and Increases Apoptosis of Neural Stem Cells in Rat Offspring: Aggravating Telomere Attrition as a Potential Mechanism

et al. 2023

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The effect of maternal folate status on the fetal central nervous system (CNS) is well recognized, while evidence is emerging that such an association also exists between fathers and offspring. The biological functions of telomeres and telomerase are also related to neural cell proliferation and apoptosis. The study aimed to investigate the effect of parental folate deficiency on the proliferation and apoptosis of neural stem cells (NSCs) in neonatal offspring and the role of telomeres in this effect. In this study, rats were divided into four groups: maternal folate-deficient and paternal folate-deficient diet (D-D) group; maternal folate-deficient and paternal folate-normal diet (D-N) group; maternal folate-normal and paternal folate-deficient diet (N-D) group; and the maternal folate-normal and paternal folate-normal diet (N-N) group. The offspring were sacrificed at postnatal day 0 (PND0), and NSCs were cultured from the hippocampus and striatum tissues of offspring for future assay. The results revealed that parental folate deficiency decreased folate levels, increased homocysteine (Hcy) levels of the offspring’s brain tissue, inhibited proliferation, increased apoptosis, shortened telomere length, and aggravated telomere attrition of offspring NSCs in vivo and in vitro. In vitro experiments further showed that offspring NSCs telomerase activity was inhibited due to parental folate deficiency. In conclusion, parental folate deficiency inhibited the proliferation and increased apoptosis of offspring NSCs, maternal folate deficiency had more adverse effects than paternal, and the mechanisms may involve the telomere attrition of NSCs.

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Effects of maternal folic acid supplementation during pregnancy on infant neurodevelopment at 1 month of age: a birth cohort study in China

Cited by 10 publications

References 45 publications

Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review

Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review

Impact of Maternal Nutrition on Child Neurodevelopment: Insights from Recent Studies

Parental Folate Deficiency Inhibits Proliferation and Increases Apoptosis of Neural Stem Cells in Rat Offspring: Aggravating Telomere Attrition as a Potential Mechanism

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