Effects of maternal caffeine intake during lactation on molar enamel surfaces in new-born rats

Hashimoto, Komei; Joseph, Fred; Falster, Alexander U.; Simmons, William B.; Nakamoto, Tetsuo

doi:10.1016/0003-9969(92)90005-s

Cited by 8 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results confirm findings of past studies [Nakamoto et al, 1985;Hashimoto et al, 1992]. We have found there was greater dissolution o f calcium and magnesium content in the 1st molars of the caffeine group than in the noncaf feine group.…”

Section: Discussionsupporting

confidence: 92%

Effects of Caffeine Intake during Gestation and Lactation on the Acid Solubility of Enamel in Weanling Rats

Schneider¹,

Alonzo²,

Nakamoto

et al. 1995

Caries Res

View full text Add to dashboard Cite

The purpose of this study was to evaluate the effects of dietary caffeine during gestation and lactation on the acid solubility of molar teeth of weanling rats. Nineteen pregnant dams were divided into two groups. The 9 dams in the control group were fed a 20% protein diet supplemented with caffeine (2 mg/l00 g BW) throughout the experiment. At birth, 8 pups were randomly assigned to each dam. Pups were killed on day 22. The 1st and 2nd molars were removed from each pup’s maxilla and mandible. Four randomly selected molars from each litter were placed in a chamber and bathed with a flow of acid solution and the amount of mineral dissolved from the enamel was determined. The results showed that the amount of dissolved Ca and Mg from enamel surfaces of 1st molars from rats in the caffeine group after exposure to acid was consistently greater than that of the non caffeine group. In the 2nd molars there was no significant difference between caffeine and noncaffeine groups. Scanning electron microscopy revealed an alteration of the enamel surface of the 1st molars of the caffeine group after acid exposure. These results indicate that caffeine intake during gestation and lactation would have a deleterious effect on dental enamel of 1st molars in newborn rats.

show abstract

Section: Discussionsupporting

confidence: 92%

Effects of Caffeine Intake during Gestation and Lactation on the Acid Solubility of Enamel in Weanling Rats

Schneider¹,

Alonzo²,

Nakamoto

et al. 1995

Caries Res

View full text Add to dashboard Cite

show abstract

“…The apparent effects of crystallization by caffeine on the enamel of first molars where calcium, phosphorus and magnesium were released more of the teeth in the caffeine exposed offspring (Table 1). The first molars showed a statistically significant amount of dissolution in the caffeine group of the respective ions measured for 80 minutes compared to the non-caffeine control group [16].…”

Section: The Effect Of Caffeine On Enamel 21 Dissolution Studiesmentioning

confidence: 81%

“…This explains why the caffeine group of the teeth showed the higher dissolution of each ion from the surface of enamel throughout the experimental period [16].…”

Section: Crystallization Studies Of Hapmentioning

confidence: 90%

“…The teeth were exposed to weak acid for 80 minutes and four fractions were collected at 20 minutes intervals. The experimental procedures were described in detail [16,17]. The enamel surface of secondary electron photomicrographs are shown in the control (Figure 1) and caffeine group (Figure 2).…”

Section: The Effect Of Caffeine On Enamel 21 Dissolution Studiesmentioning

confidence: 99%

“…Because the teeth were affected by caffeine it is natural to make a simple assumption, that is, is it possible to produce in vivo dental caries in the caffeine group [16].…”

Section: Cariogenic Studiesmentioning

confidence: 99%

See 2 more Smart Citations

The Contrasting Effects between Caffeine and Theobromine on Crystallization: How the Non-fluoride Dentifrice Was Developed

Nakamoto¹,

Falster²,

Simmons³

2022

Dentistry

View full text Add to dashboard Cite

Caffeine and theobromine are members of the xanthine family. Coffee and soft drinks contain caffeine, whereas, in cacao, theobromine is the main ingredient. The mineral contents of the tooth which sucked the caffeine-containing dam’s milk were decreased. To determine if caffeine would affect enamel, dams were fed with a caffeine and pups were killed and first and second molars were extracted. Enamel was exposed to the acid solution and dissolved minerals from the enamel were measured. Calcium, phosphorus and magnesium from the first molars of the caffeine group were significantly dissolved. To determine why minerals were released, enamel was separated. The crystallite size of the enamel from the caffeine group showed decreased. If the pups with the same dietary regimen, but given a cariogenic diet, the caffeine group should show a higher incidence of dental caries. The caffeine group revealed higher caries scores. An in vitro experiment to grow apatite crystals was conducted, adding the various members of the xanthine. Theobromine produced larger crystal sizes than caffeine. Theobromine was added to the maternal diet. Dissolution experiments revealed that these minerals were far less dissolved. Comparative studies of the various parameters between theobromine and fluoride were conducted. Theobromine was superior to fluoride in every aspect.

show abstract

Physical examination of caffeine's effects on the enamel surface of first molar in new-born rats

Falster

Hashimoto

Nakamoto

et al. 1992

Archives of Oral Biology

View full text Add to dashboard Cite

Effects of maternal caffeine intake during lactation on molar enamel surfaces in new-born rats

Cited by 8 publications

References 16 publications

Effects of Caffeine Intake during Gestation and Lactation on the Acid Solubility of Enamel in Weanling Rats

Effects of Caffeine Intake during Gestation and Lactation on the Acid Solubility of Enamel in Weanling Rats

The Contrasting Effects between Caffeine and Theobromine on Crystallization: How the Non-fluoride Dentifrice Was Developed

Physical examination of caffeine's effects on the enamel surface of first molar in new-born rats

Contact Info

Product

Resources

About