Effects of maternal anxiety and depression on fetal neuro-development

Reissland, Nadja; Froggatt, Suzanne; Reames, E.; Girkin, John M.

doi:10.1016/j.jad.2018.08.047

Cited by 24 publications

(32 citation statements)

References 48 publications

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“…3) indicates that there might be potential to use fine-grained movement analysis to highlight specific movements, such as lip parting and lip puckering, which may be predictive of fetal state. Furthermore, other specific movements (e.g., lip pull) might be influenced by maternal mental health which has previously been shown indicative of neurobehavioral development, such as increased eye-blink rate in fetuses of anxious mothers [5]. These specific movements could potentially be used as prenatal markers for adverse neurodevelopment.…”

Section: Hg Affects Fetal Movementmentioning

confidence: 98%

“…Although the placenta selectively supplies necessary nutrients throughout pregnancy, fetal growth is most vulnerable to maternal dietary deficiencies (e.g., protein and micronutrients) during placental development early in pregnancy [3]. Not only nutritional status, but also maternal mental health (stress, anxiety and depression) has been identified as a significant prenatal factor predicting postnatal development [4,5]. The time from conception to 2 years is when individuals are most sensitive to factors leading to chronic disease in adult life [6][7][8].…”

Section: Nutritional Stress and Pregnancy Outcomesmentioning

confidence: 99%

“…Given that 0.5-3% of pregnant women suffer from diagnosed HG [13,14], the aim of this pilot study was to test whether HG is reflected in fetal health expressed in fetal movement profiles in later pregnancy, and whether the nutritional stress on the mother can be assessed using isotopic analysis of hair. There is a need for non-invasive measures to test effects of HG during pregnancy with the potential to establish not only growth parameters, but also cognitive and affective parameters [5,15]. With the advent of 4D ultrasound scanning, it is now possible to establish fetal movement profiles as a way of assessing their development.…”

Section: Current Studymentioning

confidence: 99%

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Prenatal effects of maternal nutritional stress and mental health on the fetal movement profile

Reissland

Millard

Wood

et al. 2020

Arch Gynecol Obstet

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Purpose Prenatal sub-optimal nutrition and exposure to maternal stress, anxiety and depression in pregnancy have been linked to increased postnatal morbidity and mortality. Fetal growth is most vulnerable to maternal dietary deficiencies, such as those evident in hyperemesis gravidarum (HG), early in pregnancy. The purpose of this pilot study was to examine the effects of HG on fetal movement profiles as a measure of fetal healthy development in the 3rd trimester of pregnancy, and to assess whether nutritional stress on the mother can be evaluated using isotopic analysis of hair. Method We analyzed fetal movement profiles using 4D ultrasound scans at 32-and 36-weeks' gestation. Fetuses of women (N = 6) diagnosed with HG, having lost more than 10% of their body weight in the first trimester of pregnancy were compared to a healthy group (N = 6), controlling for stress, depression and anxiety. We tested carbon and nitrogen isotope ratios in maternal hair as a measure of both diet and nutritional changes due to catabolism of body proteins and fats. Results HG and catabolism were significantly correlated (p = 0.02). Furthermore, at 32-weeks' gestation movement profiles of fetuses of mothers with HG differed significantly from the movement profiles of fetuses of healthy mothers. Fetuses of mothers suffering from HG showed a significantly increased ratio of fine-grained movements at 32 weeks (p = 0.008); however, there were no significant differences detectable at 36-weeks' gestation. Conclusion The effect of HG on fetal development as expressed by variations in fetal movement profiles in this pilot study suggest that prenatal effects of HG can be measured using movement profiles. Isotope analysis of hair can supplement this with information on nutritional imbalances early in pregnancy.

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Section: Hg Affects Fetal Movementmentioning

confidence: 98%

Section: Nutritional Stress and Pregnancy Outcomesmentioning

confidence: 99%

Section: Current Studymentioning

confidence: 99%

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Prenatal effects of maternal nutritional stress and mental health on the fetal movement profile

Reissland

Millard

Wood

et al. 2020

Arch Gynecol Obstet

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“…We examined these movements when foetuses were stimulated cross modally with sound and light. Our rationale is twofold: (i) prior research has found that sound and light stimulation increases reactions in normally developing foetuses, and hence is an optimal condition for observing foetal facial reactions; (ii) foetal reactions to stimulation can be interpreted as precursors of neurocognitive functioning and muscle tone and, given the established neurocognitive deficits and hypotonia in PWS children, foetal reactions to stimulation are hypothesised to differ prenatally.…”

mentioning

confidence: 99%

“…The stimuli applied consisted of light and sound visible and audible to foetuses at the ages observed gestation (see for a detailed description of the stimuli and coding). The 4D ultrasound scans were then coded offline using the Fetal Observable Movement System and Coders were blind to case‐control status. Reliability tests were carried out by independent coders on 10% of observations with Cohen's Kappa mean = 0.93 (range 0.66–0.99).…”

mentioning

confidence: 99%

Comparing a foetus diagnosed with Prader–Willi syndrome with non‐affected foetuses during light and sound stimulation using 4D ultrasound

2018

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Maternal Early Life Adversity and Infant Stress Regulation: Intergenerational Associations and Mediation by Maternal Prenatal Mental Health

Barclay

Rinne

Somers

et al. 2022

Res Child Adolesc Psychopathol

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Early life adversity is a potent risk factor for poor mental health outcomes across the lifespan, including offspring vulnerability to psychopathology. Developmentally, the prenatal period is a sensitive window in which maternal early life experiences may influence offspring outcomes and demarcates a time when expectant mothers and offspring are more susceptible to stressful and salutary influences. This prenatal plasticity constituted the focus of the current study where we tested the association of maternal early life adversity with infant stress regulation through maternal prenatal internalizing symptoms and moderation by prenatal social support. Mother-infant dyads (n = 162) were followed prospectively and mothers completed assessments of social support and depressive and anxiety symptoms across pregnancy. Infants completed standardized stress paradigms at one month and six months. There were several key findings. First, maternal prenatal depressive symptoms significantly mediated predictions of infant cortisol reactivity to the heel stick at one month from maternal early life adversity: specifically, maternal early life adversity positively predicted depressive symptoms in pregnancy, which in turn predicted dampened infant cortisol reactivity. Second, prenatal social support did not significantly moderate predictions of depressive or anxiety symptoms in pregnancy from maternal early life adversity nor did it alter the associations of maternal depressive or anxiety symptoms with infant stress regulation. These results suggest that maternal prenatal mental health is a key mechanism by which maternal early life adverse experiences affect offspring risk for psychopathology. We discuss potential clinical and health implications of dysregulated infant cortisol reactivity with respect to lifespan development.

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Effects of maternal anxiety and depression on fetal neuro-development

Cited by 24 publications

References 48 publications

Prenatal effects of maternal nutritional stress and mental health on the fetal movement profile

Prenatal effects of maternal nutritional stress and mental health on the fetal movement profile

Comparing a foetus diagnosed with Prader–Willi syndrome with non‐affected foetuses during light and sound stimulation using 4D ultrasound

Maternal Early Life Adversity and Infant Stress Regulation: Intergenerational Associations and Mediation by Maternal Prenatal Mental Health

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