Effects of maternal age on the mode of delivery following induction of labor in nulliparous term pregnancies: A retrospective cohort study

Abstract

Background and Aim: Increased maternal age at the time of pregnancy and labor is believed to have potential complications. To evaluate the effects of maternal age on the mode of delivery among nulliparous women with term pregnancies who underwent labor induction. Methods: In this retrospective cohort study, 313 women with the gestational age of at least ≥37 weeks, were enrolled. They were divided based on their maternal ages as: Group A < 35 years old (y/o) and Group B ≥ 35 y/o patients. Demographic features and other variables (i.e., past medical history, social history, indications and methods of labor induction, causes of cesarean delivery) were recorded from patients' files. Final outcomes were categorized as: primary (i.e., rate of cesarean section: C/S) and (b) secondary (i.e., duration of labor, postpartum complications, neonatal variables). All data were analyzed by the SPSS ver.21 software.Results: Median and interquartile ranges of gestational age were not significantly different, comparing the two groups (p = 0.415), although these variables were significantly different regarding maternal height among the two groups (p = 0.007).There was a significant relationship between the methods of labor induction among the two groups (p = 0.005). There was a prominent statistical relationship between (a) C/S deliveries and also (b) indications of C/S among the two groups (p = 0.004 and p = 0.033, respectively). Univariate logistic regression test revealed maternal age groups, neonatal weight, and history of underlying diseases had significant results (p < 0.05).Conclusions: Increased maternal age is associated with higher rates of CS among nulliparous women with term pregnancies who underwent labor induction.

Prediction of successful labor induction in persons with a low Bishop score using machine learning: Secondary analysis of two randomized controlled trials

“…A meta‐analysis of 10 cohort studies demonstrated that individuals with BMI >30 are not only more likely to require a cesarean for failed IoL than those with a BMI between 18.5 and 24.9 kg/m 2 , but they also need higher doses of prostaglandins for cervical ripening, higher doses of oxytocin for labor induction and augmentation and a longer time to birth with and without oxytocin use 29 . The association between unplanned intrapartum cesarean births and increasing BMI categories has also been demonstrated in a large systematic review of population‐based studies, 30 With regard to the association between maternal age and failure of IoL, there have been conflicting reports 31,32 . The reasons for this association, if any, need to be further explored.…”

“…29 The association between unplanned intrapartum cesarean births and increasing BMI categories has also been demonstrated in a large systematic review of population-based studies, 30 With regard to the association between maternal age and failure of IoL, there have been conflicting reports. 31,32 The reasons for this association, if any, need to be further explored.…”

Mode of birth and DNA methylation at birth, in childhood, and in adolescence: Uncovering the relationship using ALSPAC data.

“…To correct our statistical model, we included different covariates that have been shown to affect both mode of birth and the offspring's DNAm: maternal age at childbirth (calculated from entries at 8 weeks postpartum, Dunn et al, 2017;Sharami et al, 2022), maternal education (Alfano et al, 2019;Ryding et al, 2016), maternal smoking (Richmond et al, 2015) during the last 2 months of pregnancy (informed by mothers 8 weeks postpartum), child sex (Yousefi et al, 2015), and declared child gestational week at birth (Merid et al, 2020). Maternal ethnicity and prepregnancy body mass index (BMI; calculated from height and weight measures at 12 weeks gestation) were not included as covariates because of a lack of variability in ethnicity (98.74% White) and a large number of missing values (n = 168) regarding BMI.…”

Recent Status of Pregnancies at an Advanced Maternal Age at a Japanese Perinatal Center

“…In Japan, it has also been presumed to be due to the trend of late marriage accompanying women's social advancement and the development of assisted reproductive technology (ART) [4]. However, AMA, especially for ages over 40, has been reported to be an independent risk factor for adverse obstetric outcomes [1,[5][6][7][8]. Most studies have agreed that AMA is related to an increase of adverse maternal and fetal outcomes such as preeclampsia, fetal growth restriction, prematurity, and cesarean delivery [1,[5][6][7][8].…”

“…However, AMA, especially for ages over 40, has been reported to be an independent risk factor for adverse obstetric outcomes [1,[5][6][7][8]. Most studies have agreed that AMA is related to an increase of adverse maternal and fetal outcomes such as preeclampsia, fetal growth restriction, prematurity, and cesarean delivery [1,[5][6][7][8].…”