Effects of maternal 25-hydroxycholecalciferol during the last week of gestation and lactation on serum parameters, intestinal morphology and microbiota in suckling piglets

Zhang, Lianhua; Liu, Sujie; Li, Miao; Piao, Xiangshu

doi:10.1080/1745039x.2020.1822710

Cited by 21 publications

(20 citation statements)

References 48 publications

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“…Carbohydrate fermentation is beneficial to intestinal epithelial cells due to the production of SCFA ( Wong et al., 2006 ; Li et al., 2019a ), while protein fermentation produces potentially toxic metabolites including ammonia, biogenic amines, and aromatic compounds that have adverse impacts on intestinal health ( Li et al., 2019a ). The α-diversity could be used as an indicator of the functional resilience of the gut microbial ecosystem, including species richness (Observed species, Chao, and Ace) and species diversity (Shannon, Simpson, and Good's coverage) ( Zhang et al., 2020 ). In this study, no changes were observed for species richness of the fecal samples in piglets fed with HWP, FSBM, and ESBM.…”

Section: Discussionmentioning

confidence: 99%

Different dietary protein sources influence growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites in weaned piglets

Zhang

Piao

2022

Animal Nutrition

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The inclusion of high-quality proteins are commonly used in swine production. Our research investigated the effects of hydrolyzed wheat protein (HWP), fermented soybean meal (FSBM), and enzyme-treated soybean meal (ESBM) on growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites of weaned piglets. A total of 144 piglets (weaned at 28 d) were allotted to 3 dietary treatments with 6 replicate pens per treatment and 8 piglets per pen. This study included 2 periods: d 0 to14 for phase 1 and d 15 to 28 for phase 2. Dietary treatments contained 15.90% HWP, 15.80% FSBM, and 15.10% ESBM in phase 1, and 7.90% HWP, 7.80% FSBM, and 7.50% ESBM in phase 2, respectively. The ADG of piglets in ESBM was increased ( P < 0.05) compared with HWP and FSBM during d 1–28. Compared with HWP and FSBM, ESBM increased ( P < 0.05) the ferric reducing ability of plasma (FRAP), and the serum level of superoxide dismutase (SOD) in piglets on d 14, as well as increased ( P < 0.05) the serum FRAP level in piglets on d 28. ESBM decreased ( P < 0.05) serum levels of DAO and IL-1β in piglets compared with HWP on d 28. ESBM enhanced ( P < 0.05) the relative abundance of Bacteroidetes, Oscillospiraceae and Christensenellaceae, as well as reduced the relative abundance of Clostridiaceae in the feces compared with HWP and FSBM. The PICRUSt analysis revealed that the number of gene tags related to degradation of valine, leucine and isoleucine, as well as lysine degradation in ESBM were lower ( P < 0.05) than that in HWP and FSBM. ESBM increased ( P < 0.05) the fecal butyrate level in piglets compared with FSBM, and ESBM tended to decrease ( P = 0.076) the fecal cadaverine level. Overall, ESBM had advantages over HWP and FSBM in improving antioxidant status, immune function, fecal bacteria and metabolites for weaned piglets.

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Section: Discussionmentioning

confidence: 99%

Different dietary protein sources influence growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites in weaned piglets

Zhang

Piao

2022

Animal Nutrition

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“…In addition to regulating the absorption of Ca and P in the small intestine and participating in bone mineralization, 5 vitamin D 3 is associated with immunity and antioxidant capacity, the differentiation of the intestinal epithelium, and the composition of intestinal microbiota in pigs. [6][7][8][9] Vitamin D 3 could also increase the utilization of phytate P by increasing activity of intestinal phytase. 10 However, the bioavailability of vitamin D 3 is low, and it is difficult to meet the requirements of piglets for rapid growth.…”

Section: Introductionmentioning

confidence: 99%

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

2021

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BACKGROUND: With the development of intensive farming, long-term exposure of pigs to poor light conditions is not conducive to the production of vitamin D 3 , and vitamin D 3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25-Hydroxyvitamin D 3 (25OHD 3 ) has higher bioactivity than regular vitamin D 3 . This study investigated the effects of 25OHD 3 on performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed with low Ca-P diet.RESULTS: It was found that a low Ca-P diet supplemented with 50 ∼g/kg 25OHD 3 (NC + 25-D) improved (P < 0.05) average daily gain (ADG) in phase 2 and in the overall period of the experiment, and increased (P < 0.05) the immunoglobulin G (IgG), immunoglobulin A (IgA), catalase (CAT), bone-specific alkaline phosphatase (BALP), and osteocalcin (OC) serum content on day 28 compared with a low Ca-P diet (NC), but no differences were observed between a normal Ca-P diet (PC) and the NC + 25-D diet. Compared with NC, the abundance of Firmicutes was higher (P < 0.05) in PC and NC + 25-D. NC + 25-D decreased (P < 0.05) the abundance of Streptococcaceae compared with PC and NC, and increased (P < 0.05) the abundance of Lachnospiraceae compared with NC. Serum 25OHD 3 was negatively correlated with the abundance of fecal Streptococcaceae (P < 0.05), and positively correlated with the abundance of fecal Lachnospiraceae (P < 0.05).CONCLUSION: Supplementation of 25OHD 3 in a low Ca-P diet improved serum immunity, bone biochemical parameters, and fecal microbiota such as decreased Streptococcaceae abundance and increased Lachnospiraceae abundance, which could subsequently promote growth of piglets. The effects were similar to that of a normal Ca-P diet.

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“…In this study, we focus on the fecal microbiota composition and metabolites in piglets fed with different dietary protein sources including HWP, FSBM, and ESBM. The α-diversity is regarded as indicators of functional resilience of microbial ecosystems in the intestine, including species richness (Observed species, Chao, and Ace) and species diversity (Shannon, Simpson, and Good's coverage) [39]. Our results showed that no changes were observed for species richness of the fecal samples in piglets fed with HWP, FSBM, and ESBM.…”

Section: Discussionmentioning

confidence: 53%

Different Dietary Protein Sources in Low-Protein Diets Induces Changes in Antioxidant Capacity, Immunity, Fecal Microbiota and Metabolites of Weaned Piglets

Zhang

Long

2021

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Background: The inclusion of high-quality proteins and the protein restriction are commonly used in swine production. Our study was conducted to evaluate the effects of hydrolyzed wheat protein (HWP), fermented soybean meal (FSBM), and enzyme-treated soybean meal (ESBM) in low-protein diets on antioxidant capacity, immunity, fecal microbiota and metabolites of weaned piglets.Methods: A total of 144 weaned piglets were randomly assigned to 3 dietary treatments with 6 replications of 8 piglets per pen. The experiment was divided into phase 1 ( days 0-14) and phase 2 (days 15-28). The dietary treatments contained 15.90% HWP, 15.80% FSBM, and 15.10% ESBM in phase 1, and 7.90% HWP, 7.80% FSBM, and 7.50% ESBM in phase 2, respectively.Results: The ADG of piglets in the ESBM group was higher (P < 0.05) than HWP and FSBM during days 1-28. Compared with HWP and FSBM, piglets in ESBM had higher (P < 0.05) serum levels of FRAP and SOD on days 14, as well as higher (P < 0.05) serum FRAP level on days 28. Piglets in ESBM had lower (P < 0.05) serum levels of DAO and IL-1β than HWP on day 28. ESBM significantly increased the abundance of Bacteroidetes, Oscillospiraceae and Christensenellaceae and decreased the Clostridiaceae abundance in the feces compared with HWP and FSBM. The PICRUSt analysis revealed that the number of gene tags involved in valine, leucine and isoleucine degradation and lysine degradation in ESBM were lower (P < 0.05) than HWP and FSBM. Piglets in ESBM had higher (P < 0.05) fecal butyrate content compared with FSBM, and ESBM tended to decrease (P = 0.076) fecal cadaverine level.Conclusions: Overall, ESBM had advantages over HWP and FSBM in improving antioxidant capacity, immunity, and fecal microbiota and metabolites of weaned piglets.

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Effects of maternal 25-hydroxycholecalciferol during the last week of gestation and lactation on serum parameters, intestinal morphology and microbiota in suckling piglets

Cited by 21 publications

References 48 publications

Different dietary protein sources influence growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites in weaned piglets

Different dietary protein sources influence growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites in weaned piglets

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

Different Dietary Protein Sources in Low-Protein Diets Induces Changes in Antioxidant Capacity, Immunity, Fecal Microbiota and Metabolites of Weaned Piglets

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Effects of maternal 25-hydroxycholecalciferol during the last week of gestation and lactation on serum parameters, intestinal morphology and microbiota in suckling piglets

Cited by 21 publications

References 48 publications

Different dietary protein sources influence growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites in weaned piglets

Different dietary protein sources influence growth performance, antioxidant capacity, immunity, fecal microbiota and metabolites in weaned piglets

Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

Different Dietary Protein Sources in Low-Protein Diets Induces Changes in Antioxidant Capacity, Immunity, Fecal Microbiota and Metabolites of Weaned Piglets

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Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus