Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study

Abstract

Introduction It remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer. Materials and methods We selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results (SEER) cancer registry program. We assessed the effect of marital status on overall survival (OS) and BCSS using Kaplan‐Meier curve and multivariate Cox proportional hazards regression. Results Compared with divorced/separated/widowed (DSW) patients, the married (AHR 0.7483, 95% CI: 0.729‐0.7682, P < 0.001) and single patients had better BCSS (AHR 0.9096, 95% CI: 0.8796‐0.9406, P < 0.001). Married patients kept better prognosis among all age subgroups, while the better BCSS of single patients occurred only in groups older than 35 years. As for race and hormone receptor status (HRs), the better BCSS of single patients was only observed in white race (AHR 0.881, 95% CI: 0.8457‐0.9177, P < 0.001) and patients with ER+/PR + status (AHR 0.8844, 95% CI: 0.8393‐0.932, P < 0.001). Conclusion Our findings demonstrated that married and single patients with breast cancer had better prognosis than their DSW counterparts. Age, race, and HRs could affect the correlation between marital status and BCSS.

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study

“…In addition, the widowed group had the highest (37.2%) rate of non-surgery, and inadequate treatment may also lead to deterioration of the prognosis of the widowed group [23]. Moreover, widowed patients have an increased risk of stress and mental illness due to the lack of a partner [24].…”

Influence of marital status on overall survival in adult patients with chordoma: A SEER-based study

“…In addition, the widowed group had the highest (37.2%) rate of non-surgery, and inadequate treatment may also lead to deterioration of the prognosis of the widowed group (23). Moreover, widowed patients have an increased risk of stress and mental illness due to the lack of a partner(24).…”

Marital status and survival analysis of patients with pure mucinous breast carcinoma: A SEER population-based retrospective study.

“…Some studies have suggested that the hysteresis of disease diagnosis is one reason for the poor survival outcomes of the not married patients [17]. Looking deeper, it turns out that for older breast cancer patients, several researchers have proposed that spouses promote positive health behavior (i.e.…”

“…Looking deeper, it turns out that for older breast cancer patients, several researchers have proposed that spouses promote positive health behavior (i.e. regular screening and timely medical treatment), which would promote earlier diagnosis [17,[28][29]. Late diagnosis directly affects the survival rate of cancer patients [27].…”

“…Study has indicated that the not married patients were at greater risk of presentation with metastatic disease and cancer-specific mortality [16]. Marital status is considered to be an important factor affecting the survival and prognosis of cancer patients, which has been discussed in many literature, including small intestinal adenocarcinoma, colorectal cancer, lung cancer and other cancers [17][18][19][20]. For breast cancer patients, a number of studies also have shown that married breast cancer patients have better prognosis and survival outcomes than unmarried patients, and it is clear that marital status has become an independent factor affecting the survival prognosis of breast cancer patients [17,21].…”