Effects of manipulating the nitric oxide/cyclic GMP pathway on bovine oocyte meiotic resumption in vitro

Bilodeau‐Goeseels, Sylvie

doi:10.1016/j.theriogenology.2007.05.063

Cited by 51 publications

(58 citation statements)

References 48 publications

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“…Pharmacological activation of AMPK induced nuclear maturation in cumulus-enclosed and denuded oocytes that had been arrested with dibutyryl cAMP or hypoxanthine (Downs et al, 2002). Moreover, oocyte AMPK was also activated by hormones and stress; this activation preceded GVBD, and inhibiting AMPK activity blocked the effects of these stimuli (Chen et al, 2006;Chen & Downs, 2008;LaRosa & Downs, 2006, 2007. A recent study provided evidence that AMPK is also involved after GVBD to promote the completion of meiosis and to prevent premature activation (Downs et al, 2010).…”

Section: If the Signal From Follicle Cells To Inhibit Meiosis Is Not mentioning

confidence: 99%

“…The inhibitory effect of AICAR was observed in cumulusenclosed and denuded oocytes, was reversible, increased the inhibitory effect of the AC activator FSK, was dependent on its phosphorylation by adenosine kinase and was not due to increased cAMP levels or to increased purine nucleotide synthesis (Bilodeau-Goeseels et al, 2007). Metformin [MET, one of the most widely used drugs for the treatment of type 2 diabetes and an AMPK activator (Zhou et al, 2001)], was also reported to inhibit GVBD in bovine CEO and DO by Bilodeau-Goeseels et al (2007).…”

Section: Role Of Ampk In the Control Of Bovine Oocyte Meiosismentioning

confidence: 99%

“…Is the cGMP pathway as involved in the control of bovine oocyte meiosis as it is in rodent oocytes? The cGMP analog 8-bromo-cGMP as well as the guanylate cyclase stimulators atrial natriuretic peptide and protoporphyrin 1X did not have any effect on bovine oocyte meiosis after 7h of culture (Bilodeau-Goeseels, 2007), while cGMP derivatives inhibited spontaneous nuclear maturation in rat denuded oocytes (Törnell et al, 1990). The cGMP pathway can also be activated by nitric oxide (NO), which is synthesized by NO synthase (NOS) and activates soluble cytoplasmic guanylate cyclase.…”

Section: Other Signalling Pathways Involved In the Control Of Bovine mentioning

confidence: 99%

“…The cGMP pathway can also be activated by nitric oxide (NO), which is synthesized by NO synthase (NOS) and activates soluble cytoplasmic guanylate cyclase. Inducible NOS (iNOS) inhibition studies suggested that endogenous NO is necessary for spontaneous nuclear maturation (Bilodeau-Goeseels, 2007) and/or the MI to MII transition (Matta et al, 2009;Schwarz et al, 2010). Yet, NO donors also inhibited GVBD (BilodeauGoeseels, 2007;Schwarz et al, 2008;Viana et al, 2007) but the inhibitory effect of the NO donor sodium nitroprusside was not through the cGMP/protein kinase G (PKG) pathway (Bilodeau-Goeseels, 2007).…”

Section: Other Signalling Pathways Involved In the Control Of Bovine mentioning

confidence: 99%

See 3 more Smart Citations

The Control of Meiotic Arrest and Resumption in Mammalian Oocytes

Bilodeau‐Goeseels¹,

Magyara²

2012

Meiosis - Molecular Mechanisms and Cytogenetic Diversity

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Section: If the Signal From Follicle Cells To Inhibit Meiosis Is Not mentioning

confidence: 99%

Section: Role Of Ampk In the Control Of Bovine Oocyte Meiosismentioning

confidence: 99%

Section: Other Signalling Pathways Involved In the Control Of Bovine mentioning

confidence: 99%

Section: Other Signalling Pathways Involved In the Control Of Bovine mentioning

confidence: 99%

See 2 more Smart Citations

The Control of Meiotic Arrest and Resumption in Mammalian Oocytes

Bilodeau‐Goeseels¹,

Magyara²

2012

Meiosis - Molecular Mechanisms and Cytogenetic Diversity

Self Cite

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“…In a study on the effect of varying NO concentrations on bovine oocyte nuclear maturation, Bilodeau-Goeseels (2007) reported that germinal vesicle breakdown in cumulus-enclosed oocytes was prevented or stimulated by high or low doses of the NO donor SNP respectively. These observations would suggest that NO reduction, possibly linked to transcript reduction in eNOS, is necessary for germinal vesicle breakdown (Tesfaye et al 2006, Pires et al 2009) and meiosis resumption.…”

Section: No In Oocyte Competencementioning

confidence: 99%

Nitric oxide in follicle development and oocyte competence

Basini

Grasselli

2015

Reproduction

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Apart from its well-known role in regulating endothelial function, in mammals, nitric oxide (NO) is an important signaling molecule involved in many processes, regulating different biological functions. It has been demonstrated that NO plays a role in the physiology of the reproductive system, where it acts in controlling the activity of reproductive organs in both sexes. In the female of several animal species, experimental data suggest the presence of an intraovarian NO-generating system, which could be involved in the control of follicular development. The role of NO in regulating follicular atresia by apoptosis is still controversial, as a dual action depending mostly on its concentration has been documented. NO also displays positive effects on follicle development and selection related to angiogenic events and it could also play a modulatory role in steroidogenesis in ovarian cells. Both in monovulatory and poliovulatory species, the increase in PGE 2 production induced by NO via a stimulatory effect on COX-2 activity appears to be a common ovulatory mechanism. Considerable evidence also exists to support an involvement of the NO/NO synthase system in the control of meiotic maturation of cumulus-oocyte complexes.Reproduction (2015) 150 R1-R9

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Changes in signal molecules and maturation promoting factor levels associate with spontaneous resumption of meiosis in rat oocytes

Prasad

Tiwari

Tripathi

et al. 2015

Cell Biology International

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The present study was aimed to find out changes in signal molecules and maturation promoting factor (MPF) levels during meiotic cell cycle progression from diplotene and metaphase-II (M-II) arrest, a period during which oocyte achieves meiotic competency. Data suggest that high levels of adenosine 3'-5'-cyclic monophosphate (cAMP), guanosine 3'-5'-cyclic monophosphate (cGMP), and nitric oxide (NO) are associated with diplotene arrest, while reduction in their levels correlates with reduced MPF level and meiotic resumption from diplotene arrest. On the other hand, increased intracellular NO, calcium (Ca(2+) ) as well as hydrogen peroxide (H2 O2 ) levels correlate with decreased cAMP, Thr-161 phosphorylated cyclin-dependent kinase-1 (Cdk1) as well as cyclin B1 levels. The decreased Thr-161 phosphorylated Cdk1 and cyclin B1 level reduce MPF level leading to exit from M-II arrest in oocytes cultured in vitro. These data suggest that the decrease of cAMP level and increase of cytosolic free Ca(2+) as well as H2 O2 levels associate with the reduced MPF level and meiotic resumption from diplotene arrest. On the other hand, increase of NO, cGMP, Ca(2+) as well as H2 O2 levels are associated with reduced MPF and spontaneous exit from M-II arrest in rat oocytes cultured in vitro.

show abstract

Effects of manipulating the nitric oxide/cyclic GMP pathway on bovine oocyte meiotic resumption in vitro

Cited by 51 publications

References 48 publications

The Control of Meiotic Arrest and Resumption in Mammalian Oocytes

The Control of Meiotic Arrest and Resumption in Mammalian Oocytes

Nitric oxide in follicle development and oocyte competence

Changes in signal molecules and maturation promoting factor levels associate with spontaneous resumption of meiosis in rat oocytes

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