Effects of manganese on the activity of glycolytic and gluconeogenic enzymes in the perfused rat liver

Wimhurst, Janet M.; Manchester, Keith

doi:10.1016/0014-5793(73)80561-7

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…The total Mn2+ content of perfused liver has been reported to be 50-60nmol/g wet wt. (Wimhurst & Manchester, 1973). If only 10% of this were free in the cytoplasm, this would be sufficient to cause a severe inhibition of glutamine synthetase.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver

Joseph¹,

Bradford²,

McGivan³

1979

Biochemical Journal

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Section: Discussionmentioning

confidence: 99%

Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver

Joseph¹,

Bradford²,

McGivan³

1979

Biochemical Journal

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“…Manganese exhibits the ability to impede the activity of HK and PK in human neuroblastoma (SK-N-SH) and astrocytoma (U87) cells [112], thereby resulting in the repression of glycolysis. Additionally, manganese also suppresses the lactate-induced activation of PC and phosphoenolpyruvate carboxykinase (PCK1) in rat liver [113]. The manganesecontaining compound known as manganese porphyrin (MnP) exhibits a propensity to attenuate glycolytic activity and lactate levels [114], thereby providing further evidence of the inhibitory effect of manganese on glycolysis.…”

Section: Manganese and Glucose Metabolismmentioning

confidence: 99%

The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation

Sun,

Shao,

Yan

et al. 2023

Metabolites

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Trace metal elements are of vital importance for fundamental biological processes. They function in various metabolic pathways after the long evolution of living organisms. Glucose is considered to be one of the main sources of biological energy that supports biological activities, and its metabolism is tightly regulated by trace metal elements such as iron, zinc, copper, and manganese. However, there is still a lack of understanding of the regulation of glucose metabolism by trace metal elements. In particular, the underlying mechanism of action remains to be elucidated. In this review, we summarize the current concepts and progress linking trace metal elements and glucose metabolism, particularly for the trace metal elements zinc, copper, manganese, and iron.

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Organic Synthesis with Ligases

2022

Enzyme‐Based Organic Synthesis

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Effects of manganese on the activity of glycolytic and gluconeogenic enzymes in the perfused rat liver

Cited by 8 publications

References 10 publications

Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver

Inhibition of glutamine synthetase activity by manganous ions in a cytosol extract of rat liver

The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation

Organic Synthesis with Ligases

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