Effects of manganese deficiency on the microstructure of proximal tibia and OPG/RANKL gene expression in chicks

Liu, Ran; Jin, Can; ZhenYong, Wang; Wang, Zhaojun; Wang, Jian; Wang, Lin

doi:10.1007/s11259-015-9626-5

Cited by 59 publications

(34 citation statements)

References 27 publications

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“…TRAP and cathepsin K) directly involved in osteoclast functioning (Liu et al . ). In summary, Mn deficiency can lead to impaired formation of ECM, retardation of chondrocyte differentiation and increased osteoclast activity, thereby resulting in stunted growth and resorption of bones.…”

Section: Phosphorus – the Pivotal Point Of Investigationmentioning

confidence: 97%

Mineral nutrition and bone health in salmonids

Bæverfjord

Prabhu

Fjelldal

et al. 2018

Reviews in Aquaculture

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In the recent years, challenges faced in salmonid farming with regard to deformities have helped to improve our knowledge on skeletal biology and development of bone health in salmonids. Different nutritional, genetic and environmental factors are associated with skeletal deformities in salmonids and other fish species. Minerals are a group of essential nutrients having a vital role to play in skeletal development, growth and remodelling. The knowledge generated thus far on the structural and functional importance of minerals in salmonid bone health is largely restricted to phosphorus. A brief account of dietary phosphorus-related bone deformities encountered in salmonids, critical life stages for the development of bone deformities, recent developments in the understanding of their aetiology and dietary phosphorus levels required to improve bone health are presented. The effect of increased dietary level of phosphorus in reducing bone health disorders under conditions of improved feed conversion efficiency and use of triploids in salmon farming are illustrated with help of metadata analysis from literature. With regard to the role of other essential minerals (macro-and micro-) impacting bone health in salmonids, data available are extremely limited and hence information on other fish species and mammals is summarized in relation to bone development and incidence of deformities. The need to improve mineral bioavailability, utilization and reduce effluent mineral load is presented in brief with example from Norwegian salmon farming. Refinements in mineral requirement recommendations for salmonids and advanced methodologies for studying aetiology of skeletal anomalies, bone mineral status, skeletal development and deformities are also discussed.

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Section: Phosphorus – the Pivotal Point Of Investigationmentioning

confidence: 97%

Mineral nutrition and bone health in salmonids

Bæverfjord

Prabhu

Fjelldal

et al. 2018

Reviews in Aquaculture

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“…Research conducted by Qin et al [ 22 ] indicates that Mn is a trace element necessary for the normal growth and development of bird embryos. Because Mn regulates the metabolism of hormones involved in bone metabolism [ 23 , 24 ], a diet low in Mn may increase the incidence of perosis in poultry and decrease the length of the tibia [ 25 , 26 ]. It has also been observed that a diet low in Mn may increase the production of thin-shelled eggs in laying hens [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of manganese nanoparticles on apoptosis and on redox and immune status in the tissues of young turkeys

et al. 2018

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The aim of the study was to determine whether the use of Mn nanoparticles would make it possible to reduce the level of this micronutrient added to turkey diets without adversely affecting growth performance, antioxidant and immune status, or apoptosis. The experiment was conducted on 6 groups of turkeys with 10 replications in a two-factor design with 3 dosages of manganese, 100, 50 and 10 mg/kg, and 2 sources, manganese oxide (MnO) and manganese nanoparticles (NP-Mn2O3). The study showed that irrespective of the form of Mn used, reducing the Mn level recommended by British United Turkeys for supplementation of the diet of young turkeys from 100 mg/kg to 10 mg/kg increases the content of this element in the blood with no adverse effect on growth performance or the immune system. The reduction in Mn supplementation in the form of NP-Mn2O3 from 100 to 50 and even to 10 mg/kg of turkey diet has no negative effect on antioxidant defence in young turkeys. A 50% reduction of the recommended Mn level in the form of MnO enhances lipid oxidation processes. Replacing MnO with NP-Mn2O3 in the turkey diet probably can increase apoptosis in young turkeys. On the other hand, irrespective of the form of Mn used, reducing supplementation of the turkey diet with this element from 100 to 50 and even to 10 mg/kg probably can reduce apoptosis.

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“…The climbing pieces were removed, and glycerol ethanol was added dropwise. The staining effect was observed under a microscope and photographed under a 200x microscope [22]. The myocardial tissues were rapidly fixed in 10% formaldehyde for at least 24 h and embedded in paraffin for microscopic examination.…”

Section: Determination Of the Protein Expression Of The Proteinsmentioning

confidence: 99%

IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart

Gong

Yang

Liu

et al. 2019

Oxidative Medicine and Cellular Longevity

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Insulin-like growth factor 1 (IGF1) is a multifunctional cellular regulatory factor that can regulate cell growth and development by mediating growth hormone stimulation. However, the mechanism of IGF1 dysfunction in cardiomyocyte development is seldom reported. To study this, we employed the models of IGF1 knockdown in chicken embryo in vivo and in cardiomyocytes in vitro. We detected the antioxidant capacity, PI3K/Akt pathway, energy metabolism-related genes, and myocardial development-related genes. Our results revealed that the low expression of IGF1 can significantly suppress the antioxidant capacity and increase the ROS (P<0.05) levels, activating the AMPK and PI3K pathway by inhibiting the expression of IRS1. We also found that myocardial energy metabolism is blocked through IGF1, GLUT, and IGFBP inhibition, further inducing myocardial developmental disorder by inhibiting Mesp1, GATA, Nkx2.5, and MyoD expression. Altogether, we conclude that low IGF1 expression can hinder myocardial development through the dysfunction of energy metabolism caused by ROS-dependent FOXO activation.

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Effects of manganese deficiency on the microstructure of proximal tibia and OPG/RANKL gene expression in chicks

Cited by 59 publications

References 27 publications

Mineral nutrition and bone health in salmonids

Mineral nutrition and bone health in salmonids

The effect of manganese nanoparticles on apoptosis and on redox and immune status in the tissues of young turkeys

IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart

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