Effects of malvidin, cyanidin and delphinidin on human adipose mesenchymal stem cell differentiation into adipocytes, chondrocytes and osteocytes

Saulīte, Līga; Jēkabsons, Kaspars; Kļaviņš, Māris; Muceniece, Ruta; Riekstiņa, Una

doi:10.1016/j.phymed.2018.09.029

Cited by 46 publications

(30 citation statements)

References 30 publications

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“…In osteoclasts, cyanidin has dual effects on RANKL-induced osteoclastogenesis, differentiation, and fusion [22]. One study has reported chondrogenesis-stimulating effects of cyanidin on adipose tissue derived-human mesenchymal stem cells (MSCs) [23]. Cyanidin treatment also inhibited chondrogenic and hypertrophic differentiation of MSCs via decreasing autophagic activity [24].…”

Section: Introductionmentioning

confidence: 99%

Human Amniotic Epithelial Cells as a Tool to Investigate the Effects of Cyanidin 3-O-Glucoside on Cell Differentiation

Takahashi

Ferdousi

Zheng

et al. 2021

IJMS

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Cyanidin, a kind of anthocyanin, has been reported to have chemotherapeutic activities in humans. Human amniotic epithelial cells (hAECs) are considered a potential source of pluripotent stem cells. hAECs have been used as a novel tool in regenerative cellular therapy and cell differentiation studies. In this study, to explore the effects of cyanidin-3-O-glucoside (Cy3G) on hAECs and their mechanisms, we investigated the transcriptomic changes in the Cy3G-treated cells using microarray analysis. Among the differentially expressed genes (Fold change > 1.1; p-value < 0.05), 109 genes were upregulated and 232 were downregulated. Ratios of upregulated and downregulated genes were 0.22% and 0.47% of the total expressed genes, respectively. Next, we explored the enriched gene ontology, i.e., the biological process, molecular function, and cellular component of the 37 upregulated (>1.3-fold change) and 124 downregulated (<1.3-fold change) genes. Significantly enriched biological processes by the upregulated genes included “response to muscle activity,” and the genes involved in this gene ontology (GO) were Metrnl and SRD5A1, which function in the adipocyte. On the other hand, the cell cycle biological process was significantly enriched by the downregulated genes, including some from the SMC gene family. An adipogenesis-associated gene DDX6 was also included in the cell cycle biological process. Thus, our findings suggest the prospects of Cy3G in modulating adipocyte differentiation in hAECs.

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Section: Introductionmentioning

confidence: 99%

Human Amniotic Epithelial Cells as a Tool to Investigate the Effects of Cyanidin 3-O-Glucoside on Cell Differentiation

Takahashi

Ferdousi

Zheng

et al. 2021

IJMS

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“…Like other anthocyanins, malvidin‐dependent biological effects may be of great significance. Malvidins have antioxidant, anti‐hypertensive, anti‐inflammatory, anti‐obesity, anti‐osteoarthritis, and anti‐proliferative effects (Baba, Nivetha, Chattopadhyay, & Nagini, 2017; Huang, Wang, Liu, Zheng, & Li, 2014; Saulite, Jekabsons, Klavins, Muceniece, & Riekstina, 2019). In addition, malvidins exhibit cytotoxicity against some cancer cells; therefore, they also have potential to be as anticancer drugs (Mazewski, Liang, & de Mejia, 2018; Yoshino et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway

Zhang

et al. 2020

Food Science & Nutrition

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Blueberries have great beneficial effects due to high level of anthocyanins, especially malvidin. Hepatic stellate cells (HSCs) can be activated and increase excessive extracellular matrix (ECM) components, which play a central role in liver fibrogenesis. Therefore, activated HSC’s apoptosis can be induced to recover liver fibrosis. Malvidin's effects on apoptosis in rat activated hepatic stellate T6 cells (HSC‐T6) in vitro were investigated here. High concentration of malvidin was found to significantly induce apoptosis, activate caspase‐3, increase malondialdehyde, upregulate Bax, but downregulate Bcl‐2. Moreover, malvidin upregulated the protein levels of some endoplasmic reticulum stress (ERS)‐typical markers, including caspase‐12, glucose‐regulated protein 78 (GRP78), and CCAAT/enhancer‐binding protein (C/EBP) homologous protein (CHOP), suggesting that malvidin induced HSC apoptosis by the ERS apoptosis pathway as well as the mitochondrial‐dependent pathway. These findings indicated that blueberry anthocyanins, especially malvidin, could induce activated hepatic stellate cell apoptosis and might act as one kind of functional food ingredient or a novel nutraceutical beneficial for liver health.

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“…Anthocyanins can react with free radicals through phenolic hydroxyl groups to form more stable semi‐quinone radicals, terminating the free radical chain reaction, thereby reducing and scavenging free radicals (Chen et al., 2018). Polyphenols can inhibit reactive oxygen and nitrogen, transfer electrons to free radicals, and activate antioxidant enzymes to improve oxidative stress and inflammation (Addepalli & Suryavanshi, 2018; Saulite, Jekabsons, Klavins, Muceniece, & Riekstina, 2019). To find out whether the active substances of blueberry extracts have better health benefits because of their important structure, a series of experiments were conducted.…”

Section: Resultsmentioning

confidence: 99%

Investigation on the biological activity of anthocyanins and polyphenols in blueberry

Yang

Wang

et al. 2021

Journal of Food Science

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Blueberry (Vaccinium spp.) is a fruit recognized in the world as healthy, and many of its active ingredients have important physiological functions. This study analyzed the antioxidant activity, antitumor activity, and immune function of anthocyanins and polyphenols extracted from blueberries. The crude extracts of anthocyanins and polyphenols were obtained from blueberries and then purified, and the extract exhibited excellent dose‐dependent antitumor activity and antioxidant activity in vivo and in vitro. The purified anthocyanins and polyphenol compounds showed higher antioxidant activity, whereas the crude extract had a better inhibitory effect on tumor proliferation than pure extract, and the blueberry anthocyanin and polyphenol crude product mixture showed a more powerful tumor suppressor, which may be the result of the synergistic effect of multiple compounds. The crude extracts were also more efficient at improving immune function, as reflected by measurements of change in body weight, thymus and spleen indices, macrophage phagocytosis, lymphocyte transformation capacity, superoxide dismutase activity, malondialdehyde content, and serum nitric oxide levels. These results indicate that blueberry anthocyanins and polyphenol extracts can improve immune function and reduce the metastasis and proliferation of cancer cells. This study reveals the functions of important active substances in blueberries and provides support for the development of functional health products and therapeutic drugs. Practical Application We compared the biological activity of crude and purified anthocyanins and polyphenol extracts from blueberries and tested their effects on improving immune function. This study contributes to a better understanding of the bioactivity of blueberry extracts and is valuable for further applications of blueberries in medicine.

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Effects of malvidin, cyanidin and delphinidin on human adipose mesenchymal stem cell differentiation into adipocytes, chondrocytes and osteocytes

Cited by 46 publications

References 30 publications

Human Amniotic Epithelial Cells as a Tool to Investigate the Effects of Cyanidin 3-O-Glucoside on Cell Differentiation

Human Amniotic Epithelial Cells as a Tool to Investigate the Effects of Cyanidin 3-O-Glucoside on Cell Differentiation

Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway

Investigation on the biological activity of anthocyanins and polyphenols in blueberry

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