Effects of magnesium‐substituted nanohydroxyapatite coating on implant osseointegration

Abstract

Mg-substituted HA coated surfaces promote osteogenic differentiation of preosteoblasts in vitro and may improve implant osseointegration during the early stages of bone healing compared with pure EDHA coated surfaces.

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

“…36,37 It can promote hBMSCs or osteogenic cell proliferation as well as osteogenic differentiation. [38][39][40] In fact, Mg is found in natural enamel, dentine, and bone, and is associated with biologic apatite. Therefore, Mg is often incorporated into ceramics or adulterated into an alloy with other metal elements in order to promote osseous growth on implants.…”

Needle-less electrospinning employed for calcium and magnesium phosphate coatings on titanium substrates

“…The Mg containing calcium phosphates (MgCP), such as Mg substituted hydroxyapatite (Mg-HAP), has been shown as an attractive component to improve the biocompatibility of HAP coatings. For instance, Zhao et al [20] electrochemically deposited pure HAP and Mg-HAP coatings on the surface of pure titanium discs. They showed that the Mg-HAP…”

“…Recently, growing interest has been devoted to a production of Mg containing biomaterials such as biocements [17], scaffolds [18] and coatings on metallic substrates [19][20][21] due to the beneficial biological effect of Mg emerging as a naturally occurring element in human body, especially in bones [22]. The Mg containing calcium phosphates (MgCP), such as Mg substituted hydroxyapatite (Mg-HAP), has been shown as an attractive component to improve the biocompatibility of HAP coatings.…”

<b>Avaliação histomorfométrica da neoformação óssea de enxertos de fosfato de cálcio amorfo e de hidroxiapatita em alvéolos dentais de ratos</b>

“…Já suas propriedades quer químicas, mecânicas ou biológicas, mostram que este é um importante precurssor de hidroxiapatita conforme Zhao et al (2011). Outra propriedade diz respeito confirma a formação de sítios de biomineralização descritos por Gartner (2003) ao notarmos a presença de células osteoprogenitoras como os osteoblastos, osteócitos e osteoclastos.…”

“…O fosfato de cálcio amorfo sugere atender tais requisitos . Suas propriedades químicas, mecânicas ou biológicas, mostram que este é um importante produto para a formação de hidroxiapatita in vivo ou in vitro (ZHAO et al, 2011 (ROSEMBERG, 1996). E de 3 a 5% de moléculas não colágenas são responsáveis pela promoção de sítios ativos para a biomineralização e para a adesão celular.…”