Effects of magnesium on calcification of young bone in tissue culture

Nielsen, Signe Tellerup

doi:10.1007/bf02546597

Cited by 21 publications

(10 citation statements)

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“…In a relative magnesium-deficient state, vessels exposed to the uremic milieu would readily form the calcium-phosphate complexes, resulting in rapid crystal proliferation (Boskey and Posner, 1980). In vitro evidence suggests that magnesium does not directly affect hydroxyapatite growth; rather, it acts to stabilize the precursor amorphous calcium-phosphate phase (Nielsen, 1973;Tomazic et al, 1975). The current study clearly demonstrates that magnesium supplementation increases the magnesium content relative to calcium.…”

Section: Discussionmentioning

confidence: 57%

Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease

Zelt

McCabe

Svajger

et al. 2015

J Pharmacol Exp Ther

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Chronic kidney disease (CKD) patients are commonly treated with vitamin D analogs, such as calcitriol. Recent epidemiologic evidence revealed a significant interaction between vitamin D and magnesium, since an inverse relationship between vitamin D levels and mortality mainly occurs in patients with a high magnesium intake. The aim of the study was to assess the mechanisms involved by determining whether magnesium alone or combined with calcitriol treatments differentially impacts vascular calcification (VC) in male Sprague-Dawley rats with adenine-induced CKD. Treatment with moderate doses of calcitriol (80 mg/kg) suppressed parathyroid hormone to near or slightly below control levels. Given alone, this dose of calcitriol increased the prevalence of VC; however, when magnesium was given in combination, the severity of calcification was attenuated in the abdominal aorta (51% reduction), iliac (44%), and carotid arteries (46%) compared with CKD controls. The decreases in vascular calcium content were associated with a 20-50% increase in vascular magnesium. Calcitriol treatment alone significantly decreased TRPM7 protein (↓ to ∼11%), whereas the combination treatment increased both mRNA (1.7Â) and protein (6.8Â) expression compared with calcitriol alone. In summary, calcitriol increased VC in certain conditions, but magnesium prevented the reduction in TRPM7 and reduced the severity of VC, thereby increasing the bioavailable magnesium in the vascular microenvironment. These findings suggest that modifying the adverse effect profile of calcitriol with magnesium may be a plausible approach to benefiting the increasing number of CKD patients being prescribed calcitriol.

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Section: Discussionmentioning

confidence: 57%

Magnesium Modifies the Impact of Calcitriol Treatment on Vascular Calcification in Experimental Chronic Kidney Disease

Zelt

McCabe

Svajger

et al. 2015

J Pharmacol Exp Ther

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“…The depletion of bone magnesium store is not the only skeletal effect of magnesium deficiency ; in rats 35-S-mucopolysaccharide and protein syntheses are reduced (Belanger, 1958). In calves, bone calcium accretion and bone calcium catabolism both drop sharply (Larvor, Girard and Brochart, 1964) (Nielsen, 1973), and sheep cartilage calcification was impaired (Cartier and Picard, 1955 (Eastoe, 1961) (Smith and Field, 1963 ;Hunt, 1971 (Rook, 1963) than in calves (Blaxter, Rook and MacDonald, 1954), perhaps because adult bone has very poor Mg exchange ability.…”

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confidence: 99%

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing rats

Rayssiguier¹,

Larvor²

1978

Ann. Biol. anim. Bioch. Biophys.

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“…Le magnésium osseux est moins mobilisable chez le rat adulte que chez le jeune. Ainsi, Smith et Nisbet (1968,1972) (Kruse, Orent et McCollum, 1932 ;Orent, Kruse et McCollum, 1934 ;Tufts et Greenberg, 1938 (Chiemchaisri et Phillips, 1963), le veau (Blaxter, Rook et McDonald, 1954 ;Larvor et ai., 1964), le lapin (Aikawa et David, 1969), le porc (Miller et ai., 1965aet 19656), le poulain (Harrington, 1975, la poule (Cox et Sell, 1967), et la souris (Nielsen, 1973 Forbes, 1961 ;Blaxter, 1956 ;Lai, Singer et Armstrong, 1975 (Blaxter, 1956), le porc (Miller et al,1965a et (Blaxter, 1956) Belanger,1967 ;Hunt et Belanger,1972 ;Bogoroch et Belanger, 1975). Smith et Nisbet (1968,1972) Rayssiguier, 1977 : rat ; Anast, 1974 : homme ; Heaton,1964 : rat), mais tous les résultats ne concordent pas sur ce point : parfois la parathyroïdectomie est sans effet sur la magnésémie ou le magnésium osseux (Larvor et Durlach, 1971 (1963,1964,1965 (Sorensen, Hindberg et Bank-Mikkelsen, 1971 .…”

Section: Introductionunclassified