Effects of lycopene from guava (<i>Psidium guajava</i> L.) derived products on breast cancer cells

Polinati, Renata Madureira; Teodoro, Anderson Junger; Correa, Mariana Goncalves; Casanova, Fabiana Alves; Passos, Carlos Luan Alves; Silva, Jerson L.; Fialho, Eliane

doi:10.1080/14786419.2021.1880402

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…The tannins isostrictinin, strictinin, and pedunculagin were identified as active principles in the ethanolic and n-butanol extracts. In contrast, the oral dose of the water extract that exposed statistically important hypoglycaemics activity on alloxan-induced diabetic rats in both acute and sub-acute tests was 250 mg/kg 34 . c. Reduction in the symptoms of diabetes, "hyperlipidaemia, hypercholesterolemia, and hypoadiponectinemia".…”

Section: Antidiabetic Hypoglycaemic and Antihyperlipidaemic Activitiesmentioning

confidence: 87%

Medicinal and pharmacological potential of Guava leaf powder, A Review

Rehman

Khan

2022

IJNMS

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Guava (Psidium guajava) encompasses a broad range of nutritional and therapeutic potential. Depending on the species, the fruits are 4-12 cm long and have a round or oval form. It belongs to the Myrtaceous family and mostly cultivated in tropical and subtropical climates of subcontinent including Pakistan, India and Bangladesh. The most therapeutic value could be traced in pink form of guava. The phytochemicals "quercetin, avicularin, apigenin, guaijaverin, kaempferol, hyperin, myricetin, gallic acid, catechin, epicatechin, chlorogenic acid, epigallocatechin gallate, and caffeic acid" have been investigated in the guava plant leaves for its therapeutic properties. Antidiarrheal, antihypertensive, antilipidemic, anticancer, and other health promoting benefits are associated in both of the fruits and the leaves of guava. The nutritional and phytochemical profiles of guava leaves are presented in detail in current review. Many bioactivities of guava leaf extracts are also critically investigated. Guava leaves might be employed as a component in of nutraceutical and medications due to their phytochemical profile. To prove the efficacy of the guava leaf extracts, further extensive clinical trials are needed.

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Section: Antidiabetic Hypoglycaemic and Antihyperlipidaemic Activitiesmentioning

confidence: 87%

Medicinal and pharmacological potential of Guava leaf powder, A Review

Rehman

Khan

2022

IJNMS

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“…Lycopene, extracted from guava, also has cytotoxic effects on this breast cancer cell line, altering the cell cycle and increasing apoptotic cells, compared to untreated cells [ 35 ]. Of note, the C40 carotenoid astaxanthin has the highest oxygen radical scavenging capacity, and several studies have demonstrated antitumoral properties, supporting its therapeutic potential for the prevention or co-treatment of cancer [ 36 ].…”

Section: Natural Antioxidants In the Prevention And Treatment Of Brea...mentioning

confidence: 99%

Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer

2023

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Breast cancer is the leading cause of death among women worldwide, and certain subtypes are highly aggressive and drug resistant. As oxidative stress is linked to the onset and progression of cancer, new alternative therapies, based on plant-derived compounds that activate signaling pathways involved in the maintenance of cellular redox homeostasis, have received increasing interest. Among the bioactive dietary compounds considered for cancer prevention and treatment are flavonoids, such as quercetin, carotenoids, such as lycopene, polyphenols, such as resveratrol and stilbenes, and isothiocyanates, such as sulforaphane. In healthy cells, these bioactive phytochemicals exhibit antioxidant, anti-apoptotic and anti-inflammatory properties through intracellular signaling pathways and epigenetic regulation. Short-chain fatty acids (SCFAs), produced by intestinal microbiota and obtained from the diet, also exhibit anti-inflammatory and anti-proliferative properties related to their redox signaling activity—and are thus key for cell homeostasis. There is evidence supporting an antioxidant role for SCFAs, mainly butyrate, as modulators of Nrf2-Keap1 signaling involving the inhibition of histone deacetylases (HDACs) and/or Nrf2 nuclear translocation. Incorporation of SCFAs in nutritional and pharmacological interventions changes the composition of the the intestinal microbiota, which has been shown to be relevant for cancer prevention and treatment. In this review, we focused on the antioxidant properties of SCFAs and their impact on cancer development and treatment, with special emphasis on breast cancer.

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“…(Gull et al, 2012) reported high antioxidant values of Pakistani varieties of guava fruits collected from different geographical regions and of maturation stages. Numerous health-beneficial effects were reported in this fruit due to the presence of antioxidant phenolics such as anti-inflammation (El-Ahmady et al, 2013), anti-cancer (Polinati et al, 2022), anti-diabetic (YEN et al, 1992, anti-microbial (Oboh et al, 2015), anti-hyperglycaemic (Huang et al, 2020), anti-ulcer (Shady et al, 2022) and antineoplastic (Bontempo et al, 2012) activities.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of Phenolic and antioxidant profiling of white variety guava fruit (cv Arka Mridula) across the ripening stages, a statistical multi-facet study

Bylappa,

Nag

2023

Preprint

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Anatomical (Scanning Electron Microscopy), phenolic (total phenol and total flavonoid), antioxidant (DPPH, FRAP, and ABTS) and analytical profiling (LC and GC-MS) were performed for three different ripening stages (pre-ripe, ripe and over-ripe) of guava. Overall, the antioxidant-phenolic parameters showed a sigmoid pattern of change during the maturation progress of the fruit at room temperature (28±2ºC). Further, the PCA (Principal Component Analysis) established a strong correlation among different phenolic-antioxidant variables studied in this work. Analytical characterization by GC and LC-MS identified 55 (fifty-five) compounds from the guava extract. The PCA revealed a few compounds, namely, Glycine, Gamma Sitosterol, Kaempferol-4'-glucoside, Thiamine, Catechin and n-Hexadecanoic acid, could contribute significantly to the ripening process of guava. Finally, it is expected that an in-depth metabolic study of the guava ripening life cycle performed here could lead to the future development of highly stable fruit varies, with extended post-harvest shelf life at room temperature.

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Effects of lycopene from guava (Psidium guajava L.) derived products on breast cancer cells

Cited by 11 publications

References 8 publications

Medicinal and pharmacological potential of Guava leaf powder, A Review

Medicinal and pharmacological potential of Guava leaf powder, A Review

Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer

Comparative analysis of Phenolic and antioxidant profiling of white variety guava fruit (cv Arka Mridula) across the ripening stages, a statistical multi-facet study

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