Effects of luteolytic doses of prostaglandin F2α and cloprostenol on concentrations of progesterone, luteinizing hormone, follicle-stimulating hormone, glucose, insulin, growth hormone, thyroxine, prolactin and cortisol in jugular plasma of lactating dairy cows

Baishya, N.; Cooper, M. J.; Hart, I. C.; Jackson, Peter; Furr, B. J. A.; Jenkin, Graham; Pope, G. S.

doi:10.1016/s0007-1935(94)80042-1

Cited by 16 publications

(10 citation statements)

References 38 publications

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“…Over Hours 1-6, both PGF infusion and a PGF bolus stimulated an increase in both FSH and LH without a response to saline infusion or injection. The increase in LH after a luteolytic dose of PGF or a PGF analogue in a previous study occurred at a similar time as in the present study, but an FSH increase was not detected (Baishya et al 1994). In contrast to heifers, a luteolytic dose of PGF in mares causes an immediate (within 5 min) increase in both gonadotrophins, and the elevated concentrations continue for 2 h (Ginther et al 2007a).…”

Section: Discussionsupporting

confidence: 81%

“…In cattle, an acute increase in cortisol and prolactin occurred after a luteolytic dose of PGF or PGF analogue (Louis et al 1974, Furr et al 1981, Baishya et al 1994. PGs are signal transducers in neurohormone regulatory functions (Bugajski et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…After the transient increase from a single bolus treatment with PGF or a PGF analogue that induces complete luteolysis, a decrease in progesterone occurs for about 1 h and may be followed by a cessation of the decrease or a transient rebound during the next few hours before continuing the decrease (Hixon & Hansel 1974, Stellflug et al 1977, Schallenberger et al 1984, Baishya et al 1994. A single dose of PGF that induces only partial luteolysis apparently does not induce an immediate transient increase, but is associated with a more prominent transient rebound than for a dose that induces complete luteolysis (Ginther et al 2009a).…”

Section: Introductionmentioning

confidence: 99%

“…25 mg, systemically) or a PGF analogue in cattle stimulates increased concentrations of LH within 3.5 h and prolactin and cortisol within 1 h after treatment (Louis et al 1974, Tucker et al 1975, Stellflug et al 1977, Renegar et al 1978, Furr et al 1981, Schams & Karg 1982, Schallenberger et al 1984, Baishya et al 1994. It is unknown whether these hormone responses to a single luteolytic dose of PGF represent physiologic or pharmacologic responses.…”

Section: Introductionmentioning

confidence: 99%

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Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Shrestha¹,

Beg²,

Imam³

et al. 2010

Reproduction

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Progesterone and luteal blood flow effects of an i.u. 2-h infusion of 0.25 mg/h of prostaglandin F 2a (PGF) that simulated a natural pulse of 13,14-dihydro-15-keto-PGF (PGFM) were compared to the effects of a single bolus i.u. injection of PGF (4 mg) that induced complete luteolysis in heifers. Blood sampling and an estimate of the percentage of luteal area with colour-Doppler signals of blood flow were performed every 2 min for 20 min and less frequently thereafter for 6 h. After the beginning of PGF infusion or a bolus injection, progesterone increased to a peak at 14 and 10 min respectively, and was accompanied by an increase in blood flow in the bolus group but not in the infusion group. Progesterone then decreased for 1 or 2 h and was accompanied by a continued elevation in blood flow in the PGF bolus group and by a slight increase in the PGF infusion group. Progesterone then rebounded in both groups, but the rebound was greater in the infusion group. Blood flow decreased during the descending arm of the progesterone rebound. Cortisol and prolactin began to increase 6 min after the bolus PGF injection but did not increase during or after PGF infusion. The increases in cortisol, prolactin and blood flow after a PGF bolus treatment but not during a simulated PGFM pulse indicated that the bolus treatment was pharmacologic, and its use may lead to faulty conclusions on the nature of physiologic luteolysis. The comparisons between progesterone and blood flow are novel.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Shrestha¹,

Beg²,

Imam³

et al. 2010

Reproduction

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“…An overdose of PGF that induces complete luteolysis also immediately increases the concentrations of pituitary and adrenocortical hormones in cattle [25,[29][30][31] and horses [26, GINTHER AND BEG 27,32]. The immediate increase in the pituitary hormones does not occur in association with a natural PGFM pulse or when a PGFM pulse is simulated by PGF infusion in either heifers [25] or mares [26].…”

Section: Nonphysiological Progesterone Increase In Cattle and Horsesmentioning

confidence: 99%

Dynamics of Circulating Progesterone Concentrations Before and During Luteolysis: A Comparison Between Cattle and Horses1

Ginther

Beg

2012

Biology of Reproduction

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The profile of circulating progesterone concentration is more dynamic in cattle than in horses. Greater prominence of progesterone fluctuations in cattle than in horses reflect periodic interplay in cattle between pulses of a luteotropin (luteinizing hormone; LH) and pulses of a luteolysin (prostaglandin F2alpha; PGF2alpha). A dose of PGF2alpha that induces complete regression of a mature corpus luteum with a single treatment in cattle or horses is an overdose. The overdose effects on the progesterone profile in cattle are an immediate nonphysiological increase taking place over about 30 min, a decrease to below the original concentration, a dose-dependent rebound 2 h after treatment, and a progressive decrease until the end of luteolysis. An overdose of PGF2alpha in horses results in a similar nonphysiological increase in progesterone followed by complete luteolysis; a rebound does not occur. An overdose of PGF2alpha and apparent lack of awareness of the rebound phenomenon has led to faulty interpretations on the nature of spontaneous luteolysis. A transient progesterone suppression and a transient rebound occur within the hours of a natural PGF2alpha pulse in cattle but not in horses. Progesterone rebounds are from the combined effects of an LH pulse and the descending portion of a PGF2alpha pulse. A complete transitional progesterone rebound occurs at the end of preluteolysis and the beginning of luteolysis and returns progesterone to its original concentration. It is proposed that luteolysis does not begin in cattle until after the transitional rebound. During luteolysis, rebounds are incomplete and gradually wane. A partial rebound during luteolysis in cattle is associated with a concomitant increase in luteal blood flow. A similar increase in luteal blood flow does not occur in mares.

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Corpus luteum activity, fertility, and adrenal cortex response in lactating carora cows during rainy and dry seasons in the tropics of Venezuela

Leyva-Ocariz

Querales

Saavedra³

et al. 1996

Domestic Animal Endocrinology

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Effects of luteolytic doses of prostaglandin F2α and cloprostenol on concentrations of progesterone, luteinizing hormone, follicle-stimulating hormone, glucose, insulin, growth hormone, thyroxine, prolactin and cortisol in jugular plasma of lactating dairy cows

Cited by 16 publications

References 38 publications

Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Dynamics of Circulating Progesterone Concentrations Before and During Luteolysis: A Comparison Between Cattle and Horses1

Corpus luteum activity, fertility, and adrenal cortex response in lactating carora cows during rainy and dry seasons in the tropics of Venezuela

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