Effects of luteectomy and progesterone replacement therapy in early pregnant patients

Csapo, A.I.; Pulkkinen, M.O.; Wiest, Walter G.

doi:10.1016/0002-9378(73)90517-6

Cited by 386 publications

(127 citation statements)

References 8 publications

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“…As pregnancy proceeds, the placenta becomes the major source of steroids and the corpus luteum is dispensable. In women, the corpus luteum is necessary for the first 5-6 weeks of gestation (Csapo,Pulkkinen 8c Wiest, 1973 ;Csapo & Pulkkinen, 1978) whereas pregnancy in the rhesus monkey will continue in the absence of the corpus luteum after Day 21 (Tullner & Hertz, 1966;Goodman & Hodgen, 1979 Peripheral steroid concentrations throughout pregnancy in the marmoset monkey have been reported (Chambers & Hearn, 1979). Although there is evidence that the placenta is the major source of progesterone by Week 10 of pregnancy (Hearn & Chambers, 1980), very little is known about the site of production of steroids before this time.…”

Section: Introductionmentioning

confidence: 99%

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Hodges¹,

Henderson²,

Hearn³

1983

Reproduction

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Section: Introductionmentioning

confidence: 99%

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Hodges¹,

Henderson²,

Hearn³

1983

Reproduction

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“…Serum levels of progesterone increase progressively during human pregnancy and remain high until delivery of the placenta (Csapo et al 1973, Speroff et al 1994, Stjernholm et al 1997. In other species, such as rodents and rabbits, which depend on an active corpus luteum for progesterone synthesis throughout pregnancy, labor is initiated by prostaglandin F 2 PGF 2  from the endometrium, activating prostaglandin F (FP)-receptors in the corpus luteum leading to luteolysis (Sugimoto et al 1997).…”

Section: Systemic Effectsmentioning

confidence: 99%

“…Progesterone is holding the uterine myometrium in a quiescent state, "a progesterone block", during pregnancy by suppressing the propagation of electrical activity between the excitable myocyte membranes (Csapo 1956, Csapo et al 1973. The genomic and nongenomic pathways co-operate to maintain myometrial relaxation.…”

Section: The Myometriummentioning

confidence: 99%

Progesterone in Human Pregnancy and Parturition

Stjernholm¹

2012

Sex Hormones

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“…Low progesterone production renders endometrial maturation inadequate for nidation and egg development. 8,9 Immunological alterations have been cited as responsible for more than 80% of RSA cases of unknown etiology. 10 The discovery of an association between antiphospholipid antibodies and RSA was a major step towards preventing the occurrence of this complication.…”

Section: Introductionmentioning

confidence: 99%

Gestational prognostic factors in women with recurrent spontaneous abortion

et al. 2006

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CONTEXT AND OBJECTIVE: Recurrent spontaneous abortion (RSA) is defined as three or more consecutive pregnancy losses before 20 weeks and is associated with several etiological factors related to genetics, anatomy, hormones, infections and immunology, for example. Many cases of RSA remain unclear. New factors or their associations may influence gestational results. The aim was to identify possible single or associated causes of RSA that could predict gestational prognosis for women undergoing investigation and treatment. DESIGN AND SETTING: Case-control study, at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp). METHODS: Two hundred and forty-six medical records of women with RSA seen at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp), between 1994 and 2003, were evaluated. Data on age, obstetric history, possible etiological factors, treatment and pregnancy outcomes were evaluated. Statistical analysis was performed using odds ratios (OR), logistic regression analysis and decision trees. RESULTS: Two hundred and twenty-nine women were included in the study. The most frequently found etiological factors were immunological, particularly alloimmune factors (93.9%). Women with a single alloimmune factor had better gestational results (77.7% deliveries) than those with other associated factors. Autoimmune factors were associated with a higher abortion rate (OR: 4.30; 95% confidence interval, CI: 1.36-13.63). No association was found between the number of abortions prior to treatment and pregnancy results. Women aged 40 or over presented the highest rate of spontaneous abortion (OR: 5.83; 95% CI: 1.12-30.40). CONCLUSION: Age over 40 years old, immunological factors and two or more concomitant factors were associated with poor gestational outcomes among the women studied.

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Effects of luteectomy and progesterone replacement therapy in early pregnant patients

Cited by 386 publications

References 8 publications

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Relationship between ovarian and placental steroid production during early pregnancy in the marmoset monkey (Callithrix jacchus)

Progesterone in Human Pregnancy and Parturition

Gestational prognostic factors in women with recurrent spontaneous abortion

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