Effects of &lt;i&gt;Bifidobacterium bifidum&lt;/i&gt; G9-1 on Nasal Symptoms in a Guinea Pig Model of Experimental Allergic Rhinitis

Tsunemine, Satoru; Isa, Yasuhiro; Shimizu, Masaki; Ohno, Hiroshi; Yamamura, Hideki

doi:10.12938/bifidus.30.1

Cited by 4 publications

(6 citation statements)

References 40 publications

(47 reference statements)

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“…Thus, we herein experimentally demonstrated that BBG9-1 alleviates the nasal blockage and relieves the development of nasal hyperresponsiveness induced by a natural allergen. We previously reported that BBG9-1 alleviates not only nasal blockage, but also sneezing induced by the antigen OVA in guinea pigs (11). We are currently unclear why the present results differ from previous findings on the influence of BBG9-1 on allergic sneezing.…”

Section: Discussioncontrasting

confidence: 99%

“…We previously reported that BBG9‐1 alleviates not only nasal blockage, but also sneezing induced by the antigen OVA in guinea pigs . We are currently unclear why the present results differ from previous findings on the influence of BBG9‐1 on allergic sneezing.…”

Section: Discussioncontrasting

confidence: 99%

“…These mechanisms have been elucidated using multiple sensitizations and long‐term challenges with air‐borne natural antigens such as cedar pollen and house dust mite. However, the guinea pig model evaluating effects of BBG9‐1 was developed by sensitizing animals with a non‐air‐borne antigen, OVA, and a subsequent single topical challenge with OVA solution. To determine longitudinal effects of BBG9‐1 on allergic rhinitis in humans, it is desirable to use an animal model that reproduces the morbidity of human allergic rhinitis.…”

mentioning

confidence: 99%

“…Unlike mice, sensitized guinea pigs clearly exhibit both sneezing and nasal blockage induced by intranasal antigen challenge . Thus, we evaluated the efficacy of BBG9‐1 in ameliorating sneezing and nasal obstruction in a guinea pig model of experimental allergic rhinitis .…”

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confidence: 99%

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Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Tsunemine¹,

Isa²,

Ohno³

et al. 2015

Microbiology and Immunology

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Previous studies using experimental animal models have reported the beneficial effects of probiotics on allergic responses; however, their long-term effects on allergic nasal symptoms in clinical settings have not yet been elucidated in detail. In the present study, a guinea pig allergic rhinitis model involving repeated inhalation challenges with a natural allergen, Japanese cedar pollen, was used to examine the longitudinal effects of Bifidobacterium bifidum G9-1 (BBG9-1) on allergic nasal symptoms. BBG9-1 was administered orally once a day. Amelioration of nasal blockage was consistently observed throughout the experimental period in the BBG9-1-treated group. Although challenge-induced sneezing was not significantly inhibited in the BBG9-1-treated group, prolonged treatment with BBG9-1 slightly reduced the frequency of sneezing. Antigen-specific IgE antibody production was also not inhibited in the BBG9-1-treated group. Increases in the numbers of eosinophils and neutrophils in nasal cavity lavage fluid collected after pollen challenge were almost completely suppressed by BBG9-1 treatment, whereas those in mast cell mediators, histamine and cysteinyl leukotrienes were not. In contrast, increases in the levels of nitric oxide metabolites were potently suppressed. Furthermore, prolonged BBG9-1 treatment markedly suppressed exogenous leukotriene D 4 -induced nasal blockage. Thus, prolonged oral administration of BBG9-1 suppresses Japanese cedar pollen-induced allergic nasal symptoms. The inhibitory mechanisms responsible may involve reductions in the responsiveness of target organs, such as endothelial cells in nasal mucosal blood vessels, to chemical mediators.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Tsunemine¹,

Isa²,

Ohno³

et al. 2015

Microbiology and Immunology

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“…Bifidobacterium bifidum G9-1 (BBG9-1) was isolated from a healthy person, and its high level of safety is certified by the fact that BBG9-1 has been used as an intestinal drug for several decades. In addition to its anti-flatulent effect, other health promotion effects of BBG9-1, including regulation of allergic reactions[12,13], hypertriglyceridemia and hyperglycemia[14], have been investigated.…”

Section: Introductionmentioning

confidence: 99%

Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors

Kawahara¹,

Makizaki²,

Oikawa³

et al. 2017

PLoS ONE

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Human rotavirus (RV) infection is a leading cause of dehydrating diarrhea in infants and young children worldwide. Since therapeutic approaches to RV gastroenteritis are limited to alleviation of dehydration with oral rehydration solutions, more direct approaches to palliate symptoms of RV gastroenteritis are required. Treatments with probiotics have been increasingly recognized as alternative safe and low cost treatments for moderate infectious diarrhea. In this study, Bifidobacterium bifidum G9-1 (BBG9-1), which has been used as an intestinal drug for several decades, was shown to have a remarkable protective effect against RV gastroenteritis in a suckling mice model. As well as prophylactic oral administration of BBG9-1 from 2 days before RV infection, therapeutic oral administration of BBG9-1 from 1 day after RV infection significantly alleviated RV-induced diarrhea. Therapeutic administration of BBG9-1 reduced various types of damage in the small intestine, such as epithelial vacuolization and villous shortening, and significantly diminished the infectious RV titer in mixtures of cecal contents and feces. It was also shown that therapeutic administration of BBG9-1 significantly increased the number of acidic mucin-positive goblet cells and the gene expression of mucosal protective factors including MUC2, MUC3, MUC4, TGFβ1 and TFF3 in the small intestine. This led to alleviation of low gut permeability shown as decreased gene expression levels of occludin, claudin-1 and villin-1 after RV infection. Furthermore, in the small intestine, therapeutic administration of BBG9-1 significantly palliated the decreased gene expression of SGLT-1, which plays an important role in water absorption. In the large intestine, administered BBG9-1 was shown to replicate to assimilate undigested nutrients, resulting in normalization of the abnormally high osmotic pressure. These results suggested that water malabsorption caused by RV infection was alleviated in mice administered BBG9-1. Thus, the present study showed that oral administration of BBG9-1 palliated diarrhea partly through protection against RV-induced lesions by inducing mucosal protective factors. Oral administration of BBG9-1 is thought to be an efficient method for management of an RV epidemic for both prophylactic and therapeutic purposes.

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Efficacy and Safety of Oral Probiotics in Children with Allergic Rhinitis: A Review

et al. 2023

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The prevalence of allergic rhinitis is rising, and it is impacting children’s growth and quality of life. To uncover unconventional treatment modalities, research was carried out to clarify the significance of novel components in the pathophysiology of allergic rhinitis. One of these elements was gut microbiota, which plays a crucial role in the development and evolution of allergic disorders. Specifically, dysbiosis, defined as impaired microbiota composition, characterizes allergic disorders. In light of this concept, probiotics (beneficial bacteria) may restore gut dysbiosis, rebalance the immune response, and indirectly influence the clinical course of allergic diseases. In this article, we discussed the role of the gut–lung axis in children and reported on new findings. We also reviewed the most relevant studies about probiotics in patients with allergic rhinitis.

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Effects of <i>Bifidobacterium bifidum</i> G9-1 on Nasal Symptoms in a Guinea Pig Model of Experimental Allergic Rhinitis

Cited by 4 publications

References 40 publications

Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors

Efficacy and Safety of Oral Probiotics in Children with Allergic Rhinitis: A Review

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