Effects of LPA receptor-mediated signaling on the modulation of cellular functions of pancreatic cancer cells cultured in fibroblast supernatants under hypoxic conditions

Takai, Miwa; Okuda, Aya; Amano, Yuka; Yashiro, Narumi; Hara, Kimihiko; Yamamoto, Mao; Tsujiuchi, Toshifumi

doi:10.1007/s10863-023-09969-4

Cited by 4 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To investigate the material cytotoxicity, CCK8 assays were carried out using extracts of materials on murine 3T3 and human HaCaT cells …”

Section: Methodsmentioning

confidence: 99%

“…Cytotoxicity. To investigate the material cytotoxicity, CCK8 assays were carried out using extracts of materials on murine 3T3 20 and human HaCaT cells. 21 Preparation of the extracts: 3% (w/v) HA solution and 8% (w/v) CS-MA (8% CM) solution was obtained by dissolving HA (8−10 kDa, 120 mg) and CS-MA (320 mg) in cell medium (4 mL) and filtered through a 0.22 μm membrane filter.…”

Section: Hygroscopicity Andmentioning

confidence: 99%

See 1 more Smart Citation

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Xia,

Xu,

Luo

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Chronic pain emerges as a major global health issue, significantly impacting individuals' health and quality of life. In this study, we designed a bilayer microneedle loaded with lidocaine nanocomposites in the inner layer and adrenaline (Adr) in the outer layer (HCP MNs) for modulated sequential release to achieve prolonged local anesthesia. The obtained HCP MNs featured an intact structure with adequate mechanical strength for efficient skin penetration. The bilayer structure of MNs was evidenced by loading two fluorescent dyes in each layer. Furthermore, these HCP MNs were capable of inducing rapid as well as prolonged local anesthetic effects in guinea pigs. Hence, the bilayer MN coloaded with Adr and lidocaine nanocomposite serves as a promising transdermal delivery platform for chronic pain management.

show abstract

“…To investigate the material cytotoxicity, CCK8 assays were carried out using extracts of materials on murine 3T3 and human HaCaT cells …”

Section: Methodsmentioning

confidence: 99%

Section: Hygroscopicity Andmentioning

confidence: 99%

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Xia,

Xu,

Luo

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…LPA also induces resistance to cisplatin and X-ray irradiation through LPAR2-induced signalling [137]. Resistance to cisplatin in this tumour type is also potentiated by hypoxia, which increases the expression of both LPAR2 and LPAR3 [138,139].…”

Section: Lpa In Drug and Radiotherapy Resistancementioning

confidence: 99%

The Emerging Role of LPA as an Oncometabolite

Karalis,

Poulogiannis

2024

Cells

View full text Add to dashboard Cite

Lysophosphatidic acid (LPA) is a phospholipid that displays potent signalling activities that are regulated in both an autocrine and paracrine manner. It can be found both extra- and intracellularly, where it interacts with different receptors to activate signalling pathways that regulate a plethora of cellular processes, including mitosis, proliferation and migration. LPA metabolism is complex, and its biosynthesis and catabolism are under tight control to ensure proper LPA levels in the body. In cancer patient specimens, LPA levels are frequently higher compared to those of healthy individuals and often correlate with poor responses and more aggressive disease. Accordingly, LPA, through promoting cancer cell migration and invasion, enhances the metastasis and dissemination of tumour cells. In this review, we summarise the role of LPA in the regulation of critical aspects of tumour biology and further discuss the available pre-clinical and clinical evidence regarding the feasibility and efficacy of targeting LPA metabolism for effective anticancer therapy.

show abstract

The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

Behrooz,

Cordani,

Fiore

et al. 2024

Seminars in Cancer Biology

View full text Add to dashboard Cite

Effects of LPA receptor-mediated signaling on the modulation of cellular functions of pancreatic cancer cells cultured in fibroblast supernatants under hypoxic conditions

Cited by 4 publications

References 31 publications

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

The Emerging Role of LPA as an Oncometabolite

The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

Contact Info

Product

Resources

About