Effects of Lower Past‐Year Serum Sodium and Hyponatremia on Depression Symptoms and Cognitive Impairments in Patients With Hemodialysis

Fan, Szu‐Shan; Lin, Liang; Chen, Vincent Chin‐Hung; Hsieh, Chin-Wen; Hsiao, Han‐Pin; McIntyre, Roger S.; Iacobucci, Michelle; Coles, Alexandria S.; Tsai, Duujian; Weng, Jun‐Cheng; Chen, Yi‐Lung

doi:10.1111/1744-9987.13395

Cited by 14 publications

(15 citation statements)

References 26 publications

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“…Significant correlations were discovered between CI, depression symptoms, and serum sodium levels. Furthermore, such differences have been observed in hyponatraemia of any severity (moderate to severe) [37]. The following study discovered a link between impaired functional status and mild chronic hyponatremia [38].…”

Section: Markers Related To Uremic Toxinsmentioning

confidence: 69%

“…Trail Making Test Part B Digit Symbol Substitution Test [36] Hyponatremia correlated with symptoms of depression. 200 HD Patient Health Questionnaire Perceived Deficit Questionnaire-5 [37] Plasma phosphorus level (>6 mg/dL, p = 0.034), inadequate dialysis dose (Kt/V < 1, 2, p = 0.023) and hyponatremia (Na < 135 mEq/L, p = 0.001) infuenced poor executive and functional status. Anemia correlated with CI (increase in Hb values improved cognitive functions); improvement in Hb (p < 0.05) correlated with cerebral artery blood flow.…”

Section: Hd 180 Hcmentioning

confidence: 99%

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Cognitive Impairment in End Stage Renal Disease Patients Undergoing Hemodialysis: Markers and Risk Factors

Olczyk

Kusztal

Gołębiowski

et al. 2022

IJERPH

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(1) Background: Cognitive impairment (CI) is common in chronic kidney disease (CKD) and patients treated with hemodialysis. (2) Methods: The systematic review was prepared following the PRISMA statement (2013). The biomedical electronic databases MEDLINE and SCOPUS were searched. (3) Results: out of 1093 studies, only 30, which met problem and population criteria, were included in this review. The risk factors for CI can be divided into three groups: traditional risk factors (present in the general population), factors related to dialysis sessions, and nontraditional risk factors occurring more frequently in the HD group. (4) Conclusions: the methods of counteracting CI effective in the general population should also be effective in HD patients. However, there is a need to develop unique anti-CI approaches targeting specific HD risk factors, i.e., modified hemodialysis parameters stabilizing cerebral saturation and blood flow.

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Section: Markers Related To Uremic Toxinsmentioning

confidence: 69%

Section: Hd 180 Hcmentioning

confidence: 99%

Cognitive Impairment in End Stage Renal Disease Patients Undergoing Hemodialysis: Markers and Risk Factors

Olczyk

Kusztal

Gołębiowski

et al. 2022

IJERPH

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show abstract

“…Patients undergoing HD can experience symptoms such as lassitude, pain, muscle cramps, nausea, vomiting, constipation, diarrhea, rash, skin dryness, sleep disorders, depression, anxiety, and emotional and sexual problems after the treatment [1,2]. Many chronic HD patients do not feel well after the treatment sessions and need some time to recover.…”

Section: Introductionmentioning

confidence: 99%

Do biochemical parameters and intradialytic symptoms affectpost‐dialysisrecovery time? A prospective, descriptive study

Özen

Cepken²,

Tosun

2021

Ther Apher Dial

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The recovery time is defined as the time required to recover from the feelings of lassitude and fatigue. The daily activities of patients are affected by dialysis sessions, requiring significant time for patients to return to their routines. This situation implies a lower quality of life for HD patients. The aim of this study was to investigate the effects of biochemical parameters and intradialytic symptoms on post-dialysis recovery time in maintenance HD patients. This study was conducted at a private dialysis center during June and August 2019. Data were collected using the "Descriptive Characteristics Form" and the "Dialysis Symptom Index." "STROBE check-list" was used for the report of the study. The study was completed with 86 participants. The median post-dialysis recovery time was 240 min (interquartile range, 120-360 min), and female patients exhibit significantly higher recovery time than male patients. The median BMI was statistically significantly higher in patients whose post-dialysis recovery time was ≥240 min. Additional findings show that the post-dialysis recovery time was shortened by 0.230 times for male patients, while intradialytic hypotension (IDH) prolonged the median post-dialysis recovery time by 3.141 times. Factors underlying the IDH should be determined in order to eradicate the issue. The study was registered in ClinicalTrials.gov with the number NCT04274556.body mass index, female gender, intradialytic hypotension, intradialytic symptoms, post-dialysis recovery time | INTRODUCTIONPatients undergoing HD can experience symptoms such as lassitude, pain, muscle cramps, nausea, vomiting, constipation, diarrhea, rash, skin dryness, sleep disorders, depression, anxiety, and emotional and sexual problems after the treatment [1,2]. Many chronic HD patients do not feel well after the treatment sessions and need some time to recover. This recovery time is defined as the time required to recover from the feelings of lassitude and fatigue. The daily routines and work life of the patients were negatively affected, so a significant amount of time is required to recover [3,4].The Dialysis Outcomes and Practice Study reported that the recovery time for patients under 2, 2-6, 7-12, and >12 h were 32%, 42%, 17% and 10% respectively [5].

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“…While KD + PL group met dietary guideline RDA for sodium, previous literature suggests that KDs may require a higher intake of sodium due the natriuretic effects of the diet (O'Donnell et al, 2014;Volek et al, 2021). Hyponatremia has a known association with depressive mood in clinical populations (Fan et al, 2020;Suárez et al, 2020). Indeed, our findings showed that supplementation with KS containing a proprietary combination of minerals elicited subjective mood amelioration, reflected here as lower depression and higher happiness scores (Figure 3), particularly when compared to subjects following a KD without KS.…”

Section: Discussionmentioning

confidence: 99%

The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults

et al. 2022

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BackgroundKetogenic diets are a commonly used weight loss method, but little is known how variations in sodium content and ketones influence cognition and mood during the early keto-adaptation period.ObjectivesTo investigate the effects of an exogenous ketone salt (KS) as part of a hypocaloric KD on mood and cognitive outcomes in overweight and obese adults. A secondary objective was to evaluate changes in biochemical markers associated with inflammatory and cognitive responses.Materials and methodsAdults who were overweight or obese participated in a 6-week controlled-feeding intervention comparing hypocaloric diets (∼75% of energy expenditure). KD groups received twice daily ketone salt (KD + KS; n = 12) or a flavor-matched placebo, free of minerals (KD + PL; n = 13). A separate group of age and BMI matched adults were later assigned to an isoenergetic low-fat diet (LFD; n = 12) as comparison to KD. Mood was assessed by shortened Profile of Mood States and Visual Analog Mood Scale surveys. Cognitive function was determined by the Automated Neuropsychological Assessment Metrics mental test battery.ResultsBoth KD groups achieved nutritional ketosis. Fasting serum glucose decreased in both KD groups, whereas glucose was unaffected in the LFD. Insulin decreased at week 2 and remained lower in all groups. At week 2, depression scores in the KD + PL group were higher compared to KD + KS. Performance in the math processing and go/no-go cognitive tests were lower for KD + PL and LFD participants, respectively, compared to KD + KS. Serum leptin levels decreased for all groups throughout the study but were higher for KD + KS group at week 6. Serum TNF-α steadily increased for LFD participants, reaching significance at week 6.ConclusionDuring a short-term hypocaloric diet, no indication of a consistent decline in mood or cognitive function were seen in participants following either KD, despite KD + PL being relatively low in sodium. WK2 scores of “anger” and “depression” were higher in the LFD and KD + PL groups, suggesting that KS may attenuate negative mood parameters during the early intervention stages.

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Effects of Lower Past‐Year Serum Sodium and Hyponatremia on Depression Symptoms and Cognitive Impairments in Patients With Hemodialysis

Cited by 14 publications

References 26 publications

Cognitive Impairment in End Stage Renal Disease Patients Undergoing Hemodialysis: Markers and Risk Factors

Cognitive Impairment in End Stage Renal Disease Patients Undergoing Hemodialysis: Markers and Risk Factors

Do biochemical parameters and intradialytic symptoms affectpost‐dialysisrecovery time? A prospective, descriptive study

The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults

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