Effects of Low-Load/High-Repetition Resistance Training on Exercise Capacity, Health Status, and Limb Muscle Adaptation in Patients With Severe COPD

Nyberg, André; Martin, Mickaël; Saey, Didier; Milad, Nadia; Patoine, Dany; Morissette, Mathieu C.; Auger, Dominique; Stål, Per; Maltais, François

doi:10.1016/j.chest.2020.12.005

Cited by 20 publications

(40 citation statements)

References 44 publications

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“…Both continuous and interval endurance training improve cardiopulmonary outcomes; however, interval-based training is used as a more effective approach to optimise the load that can be tolerated in exercise programs for clinical pulmonary patients [104]. In addition, muscle dysfunction as a consequence of lung disease (muscle atrophy, reduced oxidative capacity and a decreased proportion of type I muscle fibres) can be mitigated and even reversed with strength training interventions [105,106]. Accordingly, concurrent training (endurance and strength) stands as the preferable treatment for lung diseases to improve peak pulmonary oxygen uptake, systematic oxidative stress, muscle strength, muscle size, functional capacity, and quality of life [107,108].…”

Section: Exercise Is An Effective Treatment For Pulmonary Complicationsmentioning

confidence: 99%

Section: The Potential Role Of Exercise In Post-covid-19 Syndromementioning

confidence: 99%

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Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Jimeno-Almazán

Pallarés

Buendía-Romero

et al. 2021

IJERPH

206

137

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The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 syndrome is one of those challenges, having become increasingly common as the pandemic evolves. The latest estimates suggest that 10 to 20% of the SARS-CoV-2 patients who undergo an acute symptomatic phase are experiencing effects of the disease beyond 12 weeks after diagnosis. Although research is beginning to examine this new condition, there are still serious concerns about the diagnostic identification, which limits the best therapeutic approach. Exercise programs and physical activity levels are well-known modulators of the clinical manifestations and prognosis in many chronic diseases. This narrative review summarizes the up-to-date evidence on post-COVID-19 syndrome to contribute to a better knowledge of the disease and explains how regular exercise may improve many of these symptoms and could reduce the long-term effects of COVID-19.

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Section: Exercise Is An Effective Treatment For Pulmonary Complicationsmentioning

confidence: 99%

Section: The Potential Role Of Exercise In Post-covid-19 Syndromementioning

confidence: 99%

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Jimeno-Almazán

Pallarés

Buendía-Romero

et al. 2021

IJERPH

206

137

View full text Add to dashboard Cite

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“…Of note, the unilateral resistance-training design was arguably supportive for the pronounced resistance-training effects in COPD participants. By reducing cardiorespiratory demand, and thus facilitating higher degrees of muscle activation and muscle mass-specific intensities during exercise compared to conventional two-legged resistance exercise [ 24 ] this seems to translate into larger functional improvements for this population [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…This deterioration is accompanied by systemic co-morbidities such as reduced levels of testosterone [ 4 ], vitamin D [ 5 , 6 ] and oxygen saturation levels [ 7 ], and elevated levels of low-grade inflammation [ 8 ], which arguably leaves COPD subjects in a state of anabolic resistance [ 9 ], resulting in impaired abilities to adapt to exercise training [ 10 – 12 ]. In particular, these pathophysiologies are believed to impair adaptations to resistance training, which represent the most potent intervention for improving muscle functions [ 13 – 16 ] and preventing escalation into late-stage morbidities such as pulmonary cachexia [ 17 ]. Despite this general belief, the presence of anabolic resistance in COPD subjects and its consequences for responses to resistance training remain circumstantial.…”

Section: Introductionmentioning

confidence: 99%

Chronic obstructive pulmonary disease does not impair responses to resistance training

et al. 2021

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Background Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach. Methods Subjects with COPD (n = 20, GOLD II-III, FEV1predicted 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV1predicted 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance training interventions for 13 weeks, consisting of two weekly supervised training sessions. Leg exercises were performed unilaterally, with one leg conducting high-load training (10RM) and the contralateral leg conducting low-load training (30RM). Measurements included muscle strength (nvariables = 7), endurance performance (nvariables = 6), muscle mass (nvariables = 3), muscle quality, muscle biology (m. vastus lateralis; muscle fiber characteristics, RNA content including transcriptome) and health variables (body composition, blood). For core outcome domains, weighted combined factors were calculated from the range of singular assessments. Results COPD displayed well-known pathophysiologies at baseline, including elevated levels of systemic low-grade inflammation ([c-reactive protein]serum), reduced muscle mass and functionality, and muscle biological aberrancies. Despite this, resistance training led to improved lower-limb muscle strength (15 ± 8%), muscle mass (7 ± 5%), muscle quality (8 ± 8%) and lower-limb/whole-body endurance performance (26 ± 12%/8 ± 9%) in COPD, resembling or exceeding responses in Healthy, measured in both relative and numeric change terms. Within the COPD cluster, lower FEV1predicted was associated with larger numeric and relative increases in muscle mass and superior relative improvements in maximal muscle strength. This was accompanied by similar changes in hallmarks of muscle biology such as rRNA-content↑, muscle fiber cross-sectional area↑, type IIX proportions↓, and changes in mRNA transcriptomics. Neither of the core outcome domains were differentially affected by resistance training load. Conclusions COPD showed hitherto largely unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments and rather advocating such training as a potent measure to relieve pathophysiologies. Trial registration: ClinicalTrials.gov ID: NCT02598830. Registered November 6th 2015, https://clinicaltrials.gov/ct2/show/NCT02598830

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“…The quality of included studies was rated ≤5 points in seven trials [28][29][30][31][32][33][34] and ≥6 points in eight other studies [35][36][37][38][39][40][41][42]. The sample size of the included studies varied between 12 and 48 subjects and was calculated a priori in 7 out of 15 trials [29,33,34,36,37,41,42].…”

Section: Quality Ratingmentioning

confidence: 99%

Isolated Resistance Training Programs to Improve Peripheral Muscle Function in Outpatients with Chronic Obstructive Pulmonary Diseases: A Systematic Review

et al. 2021

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This systematic review aims to establish which isolated resistance training (RT) programs have been used in outpatients with chronic obstructive pulmonary disease (COPD) and their impact on all aspects of peripheral skeletal muscle function. Electronic databases were systematically searched up to June 2021. The eligibility criteria were: (1) randomized controlled trials investigating the effects of supervised and isolated RT programs in outpatients with COPD and (2) RT programs lasting 8–12 weeks, (3) including at least one outcome measure related to trainable muscle characteristics. Initially, 6576 studies were identified, whereas 15 trials met the inclusion criteria. All the included trials reported that isolated RT improved both upper and lower limbs’ maximal strength. Muscle endurance and power also increased after RT but received less attention in the analysis. Furthermore, few studies assessed the effect of RT on muscle mass and cross-sectional area, reporting only limited improvement. Isolated RT programs carried out 2–3 days a week for 8–12 weeks improved skeletal muscle function in individuals with COPD. The RT program should be specifically focused to the trainable muscle characteristic to be improved. For this reason, we further encourage the introduction of a detailed assessment of muscle function and structure during the pulmonary rehabilitation practice.

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Effects of Low-Load/High-Repetition Resistance Training on Exercise Capacity, Health Status, and Limb Muscle Adaptation in Patients With Severe COPD

Cited by 20 publications

References 44 publications

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Chronic obstructive pulmonary disease does not impair responses to resistance training

Isolated Resistance Training Programs to Improve Peripheral Muscle Function in Outpatients with Chronic Obstructive Pulmonary Diseases: A Systematic Review

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