Effects of Low-Level Organic Mercury Exposure on Oxidative Stress Profile

Tincu, R.C.; Cobilinschi, Cristian; Florea, Iulia Alexandra; Cotae, Ana-Maria; Băetu, Alexandru Emil; Isac, Sebastian; Ungureanu, Raluca; Droc, Gabriela; Grințescu, Ioana Marina; Mirea, Liliana

doi:10.3390/pr10112388

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to other increased plasma levels of metallic compounds, iron overload is toxic to the liver as it generates reactive oxygen species (ROS) and causes DNA damage which is further responsible for cell premature death [ 17 ]. Thus, the liver suffers a disbalance in its main functions, namely mitochondrial and lysosomal activity with a loss of antioxidant properties.…”

Section: Discussion and Literature Overviewmentioning

confidence: 99%

A “Mix and Match” in Hemochromatosis—A Case Report and Literature Focus on the Liver

Cobilinschi,

Săulescu,

Caraiola

et al. 2023

Medicina

View full text Add to dashboard Cite

Hemochromatosis is a genetic disorder characterized by increased iron storage in various organs with progressive multisystemic damage. Despite the reports dating back to 1865, the diagnosis of hemochromatosis poses a challenge to clinicians due to its non-specific symptoms and indolent course causing significant delay in disease recognition. The key organ that is affected by iron overload is the liver, suffering from fibrosis, cirrhosis or hepatocellular carcinoma, complications that can be prevented via early diagnosis and treatment. This review aims to draw attention to the pitfalls in diagnosing hemochromatosis. We present a case with multiorgan complaints, abnormal iron markers and a consistent genetic result. We then examine the relevant literature and discuss hemochromatosis subtypes and liver involvement, including transplant outcome and treatment options. In summary, hemochromatosis remains difficult to diagnose due to its symptom heterogeneity and rarity; thus, further education for practitioners of all disciplines is useful in facilitating its early recognition and management.

show abstract

Section: Discussion and Literature Overviewmentioning

confidence: 99%

A “Mix and Match” in Hemochromatosis—A Case Report and Literature Focus on the Liver

Cobilinschi,

Săulescu,

Caraiola

et al. 2023

Medicina

View full text Add to dashboard Cite

show abstract

“…Tincu et al [27] studied mercury (Hg) exposure through a fish-based diet to evaluate the correlations between Hg blood concentrations and specific biomarkers for oxidative stress that can lead to neurological and cardiovascular diseases through the exacerbation of oxidative stress.…”

mentioning

confidence: 99%