Effects of low-level exposure to xenobiotics present in paints on oxidative stress in workers

Moro, Ângela M.; Charão, Mariele Feiffer; Brucker, Natália; Bulcão, Rachel Picada; Freitas, Fernando Monteiro de; Guerreiro, Gilian; Baierle, Marília; Nascimento, Sabrina; Waechter, Fernanda; Hirakata, Vânia Naomi; Linden, Rafael; Thiesen, Flávia Valladão; Garcia, Solange Cristina

doi:10.1016/j.scitotenv.2010.06.058

Cited by 60 publications

(43 citation statements)

References 45 publications

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“…In agreement with our results the study of Moro et al (2010) and Conterato et al (2013) reported an increased MDA level in painters occupationally exposed to paint thinners.…”

Section: Discussionsupporting

confidence: 93%

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Maksoud

Aal

Ghandour

et al. 2018

Egypt J Forensic Sci

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Background: Occupational exposures to hazardous chemicals in paints cause serious health hazards in painters. The present study was designed to evaluate the possibility of hematotoxic and genotoxic effects of paint chemicals among painters in Assiut Governorate, Egypt. In addition the role of oxidative stress and apoptosis in mechanism of such toxic effects were studied. Methods: A case control study was performed on 50 male painters and 50 non-exposed healthy subjects, who were included as a control group after informed consent. Venous blood samples were obtained and analyzed for determination of total and differential blood count as hematotoxic markers as well as serum malondialdehyde (MDA) as an oxidant stress markers and total antioxidant enzymes. In addition, human B-cell lymphoma-2 (Bcl-2), caspase-3 and 8-hydroxyguanosine (8-OHdG) were assayed as markers of apoptosis and genotoxicity. Results: There was a statistically significant difference between paint workers and controls as regard total and differential blood count, serum MDA and total anti-oxidant levels. Also, statistical significant differences in caspase-3, Bcl-2 levels and 8-OHdG were observed. Conclusions: Chronic occupational exposure to paints increased the risk of hematotoxicity and genotoxicity in painters. Oxidative stress and apoptosis play a major role in such mechanism. Periodic medical examination and application of protective devices is necessary.

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“…In agreement with our results the study of Moro et al (2010) and Conterato et al (2013) reported an increased MDA level in painters occupationally exposed to paint thinners.…”

Section: Discussionsupporting

confidence: 93%

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Maksoud

Aal

Ghandour

et al. 2018

Egypt J Forensic Sci

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“…Evidence from experiments in animals and observational studies in occupationally-exposed adults suggest that exposure to high levels of Pb can induce the generation of lipid peroxidation products, alter the activities of antioxidant enzymes and cause changes to nucleic acid bases or structural damage to DNA molecules (Berrahal et al, 2011; Haleagrahara et al, 2011; Sandhir et al, 1995; Bizon et al, 2013; Garcon et al, 2007; Grover et al, 2010; Kasperczyk et al, 2012; Khan et al, 2008; Malekirad et al, 2010; Olewińska et al, 2010; Permpongpaiboon et al, 2011; Bizon et al, 2013; Garcon et al, 2004; Garcia-Leston et al, 2012; Khan et al, 2008; Moro et al, 2010; Permpongpaiboon et al, 2011). Further, among non-occupationally exposed non-pregnant US adults with low blood lead level (BLL), a positive association was reported between BLL and serum γ-glutamyltranferase (GGT), a liver enzyme and an early marker of OS, after adjusting for age, sex, race and socio-economic status (Lee et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Association of blood lead levels with urinary F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children

Roy

Queirolo

Peregalli

et al. 2015

Environmental Research

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Oxidative stress (OS) is a potential molecular mechanism for lead-induced toxicities, yet, we have limited understanding of the relation between low-level lead (Pb) exposure and OS, especially in children. This cross-sectional study examines the association between blood lead level (BLL) and two OS markers—urinary F2-8α isoprostane or isoprostane (a marker of lipid peroxidation) and 8-hydroxy-2-deoxy-Guanosine or 8-OH-dG (a marker of DNA damage) in 211 children, aged 5–8 years, from Montevideo, Uruguay. The role of dietary intakes of vitamin C and zinc in modifying the relation between BLL and OS was also examined. The mean (SD) BLL of the study children was 4.7 (2.2) μg/dL, with 30.2% children having BLL ≥5 μg/dL, the current reference level set by the US Centre for Disease Control for identifying, monitoring and management of children with elevated BLL. In covariate-adjusted analysis, there was a weak positive association between BLL and urinary isoprostane (adjusted for specific gravity) [β = 0.09, p< 0.1]. No association was found between children’s BLL and urinary 8-OH-dG. Interactions between dietary intakes of vitamin C or zinc and BLL on OS biomarkers were not consistent. However, when BLL and vitamin C or BLL and zinc were modeled together, BLL was independently associated with isoprostane concentration [β = 0.10, p< 0.05] but vitamin C or zinc intake was not. These findings suggest that there may be a potential adverse effect of BLL on OS in children with low-level Pb exposure. There is a need to study the effects of Pb on other OS measures, as well as the role of OS in mediating low-level Pb toxicity on functional outcomes.

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“…A preliminary study conducted on a group of workers from a paint and lacquer industry occupationally exposed to styrene, ethylene glycol, toluene, p-xylene, and their mixture showed a statistically elevated concentration of the two main products of LPO, MDA, and 4-hydroxynonenal in plasma, compared to the values found for nonexposed controls (Długosz and Sawicka, 1998). A previous study from our research group (Moro et al, 2010) showed a strong correlation between plasmatic LPO and blood toluene levels in painters. MDA levels also correlated to blood-lead levels as well as to the urinary biomarkers of exposure 3mHA and ortho-cresol.…”

Section: Occupational Exposure To Paintsmentioning

confidence: 60%

Evaluation of lipid damage related to pathological and physiological conditions

Garcia¹,

Grotto²,

Bulcão³

et al. 2012

Drug and Chemical Toxicology

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Several diseases and xenobiotics are known to generate reactive species that may trigger oxidative stress when not properly scavenged by the antioxidant defenses and result in tissue damage. We investigated lipid peroxidation (LPO) as a possible mechanism for tissue damage in some pathologies, in the normal aging process, and in subjects exposed to organic solvents. Plasmatic malondialdehyde (MDA) was quantified by high-performance liquid chromatography with visible wavelength detection in 239 subjects and divided into the following: acute myocardium infarction (AMI), diabetes without complications (D) and hemodialysis (HD) patients; into healthy children, adults, and elderly, all nonexposed to xenobiotics; and into painters occupationally exposed to organic solvents (P). Troponin, glycated hemoglobin, and transminases [aspartate aminotransferase (AST) and alanine aminotransferase] were analyzed. An increase in LPO was observed in AMI, D, HD, and P groups, when compared to healthy adults. No correlation between MDA and age was found. Further, we found positive correlations between MDA versus troponin (r = 0.47), MDA versus HbA1c (r = 0.56), and MDA versus AST (r = 0.41) in AMI, diabetics, and painters, respectively. This work has demonstrated increased lipid and protein damages in myocardium and blood, along with an alteration of hepatic transaminase activities and induction of LPO, suggesting that MDA levels are important to evaluate the extent of tissue alterations and development of acute and chronic conditions.

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Effects of low-level exposure to xenobiotics present in paints on oxidative stress in workers

Cited by 60 publications

References 45 publications

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Assessment of Hematotoxicity and Genotoxicity among paint Workers in Assiut Governorate: a case control study

Association of blood lead levels with urinary F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children

Evaluation of lipid damage related to pathological and physiological conditions

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