Effects of Low Doses of Melatonin on Late Afternoon Napping and Mood

Terlo, L; Laudon, Moshe; Tarasch, R; Schatz, T. J.; Caine, Y G; Zisapel, Nava

doi:10.1076/brhm.28.1.2.12980

Cited by 11 publications

(5 citation statements)

References 19 publications

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“…Fatigue and sleepiness were assessed using the Bond‐Lader visual analogue questionnaire previously used to demonstrate fatigue‐inducing effects of melatonin in humans [Gorfine et al, 2006; Terlo et al, 1997]. This is a self‐report form that includes 16, 10‐cm visual analogue scales and provides the subjective ratings of mood fatigue and sleepiness.…”

Section: Methodsmentioning

confidence: 99%

Late evening brain activation patterns and their relation to the internal biological time, melatonin, and homeostatic sleep debt

Gorfine

Zisapel

2009

Human Brain Mapping

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Sleep propensity increases sharply at night. Some evidence implicates the pineal hormone melatonin in this process. Using functional magnetic resonance imaging, brain activation during a visual search task was examined at 22:00 h (when endogenous melatonin levels normally increase). The relationships between brain activation, endogenous melatonin (measured in saliva), and self-reported fatigue were assessed. Finally, the effects of exogenous melatonin administered at 22:00 h were studied in a double blind, placebo-controlled crossover manner. We show that brain activation patterns as well as the response to exogenous melatonin significantly differ at night from those seen in afternoon hours. Thus, activation in the rostro-medial and lateral aspects of the occipital cortex and the thalamus diminished at 22:00 h. Activation in the right parietal cortex increased at night and correlated with individual fatigue levels, whereas exogenous melatonin given at 22:00 h reduced activation in this area. The right dorsolateral prefrontal cortex, an area considered to reflect homeostatic sleep debt, demonstrated increased activation at 22:00 h. Surprisingly, this increase correlated with endogenous melatonin. These results demonstrate and partially differentiate circadian effects (whether mediated by melatonin or not) and homeostatic sleep debt modulation of human brain activity associated with everyday fatigue at night. Hum Brain

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Section: Methodsmentioning

confidence: 99%

Late evening brain activation patterns and their relation to the internal biological time, melatonin, and homeostatic sleep debt

Gorfine

Zisapel

2009

Human Brain Mapping

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“…Variables are measured by the distance in millimeter from the left edge of each of the scale. The Bond–Lader has previously been found useful to demonstrate fatigue inducing effects of melatonin in humans [28, 36]. Questionnaires were filled prior to the first and second fMRI sessions.…”

Section: Methodsmentioning

confidence: 99%

Nap and melatonin‐induced changes in hippocampal activation and their role in verbal memory consolidation

Gorfine

Yeshurun

Zisapel

2007

Journal of Pineal Research

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Overnight sleep contributes to memory consolidation; even a short nap improves memory performance. Such improvement has been linked to hippocampal activity during sleep. Melatonin has been shown to affect the human hippocampus and to induce 'sleep like' changes in brain activation. We therefore conducted and compared two functional magnetic resonance imaging studies: the first study assessed the effect of a 2-hr mid-day nap versus an equal amount of wakefulness on a verbal memory task (unrelated word pair association); the second assessed the effect of melatonin versus placebo (both conditions without nap) on a similar task. We report that following a nap relative to wakefulness, successful retrieval-related activation in the parahippocampus is decreased. A smaller decrease is seen in wakefulness with melatonin but not placebo. In parallel, an improvement in verbal memory recall was found after a nap compared with wakefulness but not with melatonin during wakefulness compared with placebo. Our findings demonstrate effects of melatonin that resemble those of sleep on verbal memory processing in the hippocampus thus suggesting that melatonin, like sleep, can initiate offline plastic changes underlying memory consolidation; they also suggest that concomitant rest without interferences is necessary for enhanced performance.

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“…Melatonin (0.1, 0.5, and 5 mg p.o.) decreased wake time after sleep onset and increased feelings of sleepiness and fatigue in the late afternoon (17:00-21:00 hours) in healthy volunteers (Terlo et al, 1997). When melatonin (0.1-10 mg) was administered at 11:45 hours all doses significantly increased sleep duration and self-reported sleepiness and fatigue.…”

Section: Melatonin Administration Induces Sleep In Healthy Subjectsmentioning

confidence: 97%

The Use of Melatonin as a Chronobiotic-Cytoprotective Agent in Sleep Disorders

Cardinali¹

2005

The Physiologic Nature of Sleep

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Effects of Low Doses of Melatonin on Late Afternoon Napping and Mood

Cited by 11 publications

References 19 publications

Late evening brain activation patterns and their relation to the internal biological time, melatonin, and homeostatic sleep debt

Late evening brain activation patterns and their relation to the internal biological time, melatonin, and homeostatic sleep debt

Nap and melatonin‐induced changes in hippocampal activation and their role in verbal memory consolidation

The Use of Melatonin as a Chronobiotic-Cytoprotective Agent in Sleep Disorders

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