Effects of low-dose rapamycin on lymphoid organs of mice prone and resistant to accelerated senescence
Rafael dos Santos Barros,
Luiz Adriano Damasceno Queiroz,
Josiane Betim de Assis
et al.
Abstract:Aging is a complex, natural, and irreversible phenomenon that subjects the body to numerous changes in the physiological process, characterized by a gradual decline in the organism’s homeostatic mechanisms, closely related to immunosenescence. Here, we evaluated the regulation of immunosenescence in lymphoid organs of senescence-accelerated prone 8 (SAM-P8) and senescence-accelerated resistant 1 (SAM-R1) mice treated with a low dose of rapamycin (RAPA). Mice were treated with a dose of 7.1 µg/kg RAPA for 2 mon… Show more
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