Effects of lorazepam on deductive reasoning

Pompéia, Sabine; Manzano, Gilberto Mastrocola; Pradella-Hallinan, Márcia; Bueno, Otávio

doi:10.1007/s00213-007-0864-2

Cited by 7 publications

(1 citation statement)

References 43 publications

(118 reference statements)

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“…Subjects were familiarized with all tests before drug intake. The test battery was initiated when theoretical peak-plasma concentration of the active treatment was reached (2 h after ingestion; Ameer and Greenblatt, 1981) and included other results reported elsewhere (Pompéia et al, 2007). All tests were carried out with optical corrections if necessary.…”

Section: Methodsmentioning

confidence: 99%

Effects of lorazepam on visual perceptual abilities

Pompéia

Pradella-Hallinan

Manzano

et al. 2008

Human Psychopharmacology

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Section: Methodsmentioning

confidence: 99%

Effects of lorazepam on visual perceptual abilities

Pompéia

Pradella-Hallinan

Manzano

et al. 2008

Human Psychopharmacology

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A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia

Segura

McGhee

Sala

et al. 2020

Human Psychopharmacology

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Objective: Acute administration of benzodiazepines is considered a pharmacological model of general organic anterograde amnesias (OAA). We sought to determine which type of amnesia these drugs best model by comparing the effects of diazepam with those reported in amnesiacs regarding working memory capacity (WMC), susceptibility to retroactive interference (RI), and accelerated forgetting. Methods:In this double-blind, parallel-group design study, 30 undergraduates were randomly allocated to acute oral treatments with 15 mg diazepam or placebo. WMC and story recall were assessed pre-and post-treatment. Story presentation was succeeded by 10 min of RI (spotting differences in pictures) or minimal RI (doing nothing in a darkened room). Delayed story recall was assessed under diazepam and 7 days later in a drug-free session to assess accelerated forgetting.Results: Recall of stories encoded under diazepam, whether reactivated or not, was severely impaired (anterograde amnesia). However, diazepam did not impair WMC, increase susceptibility to RI, or accelerate forgetting.Conclusions: Diazepam's amnestic effects mirror those in patients with probable severe medial temporal damage, mostly restricted to initial consolidation and differ from other OAA (Korsakoff syndrome, frontal, transient epileptic, posttraumatic amnesia, and most progressive amnesias) in terms of WMC, susceptibility to RI and accelerated forgetting.

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Current awareness: Pharmacoepidemiology and drug safety

2008

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Effects of lorazepam on deductive reasoning

Abstract: Acute lorazepam administration affected reasoning in two ways: it slowed processing nonspecifically when working memory demands increased and augmented validation time depending on the difficulty in generating and/or manipulating mental representations by the central executive.

Cited by 7 publications

References 43 publications

Effects of lorazepam on visual perceptual abilities

Effects of lorazepam on visual perceptual abilities

A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia

Current awareness: Pharmacoepidemiology and drug safety

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