Effects of long-term treatment for obstructive sleep apnea on pulse wave velocity

Saito, Tsunenori; Saito, Tsunehiro; Sugiyama, Shigeyuki; Asai, Kuniya; Yasutake, Masahiro; Mizuno, Kyoichi

doi:10.1038/hr.2010.77

Cited by 29 publications

(33 citation statements)

References 29 publications

(45 reference statements)

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“…Similarly, Shiina et al 63 found 3 months of CPAP to lead to a significant decrease in baPWV but not peripheral blood pressure. Saito et al, 64 however, found 6 months of CPAP treatment to decrease both baPWV and peripheral blood pressure in both hypertensive and normotensive patients. Interestingly, following the significant decrease observed after the first 6 months of treatment, baPWV gradually increased in both groups over the following 18 months under study, whereas peripheral blood pressure did not.…”

Section: Resultsmentioning

confidence: 97%

Increased arterial stiffness in obstructive sleep apnea: a systematic review

et al. 2010

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Obstructive sleep apnea is a prevalent disease that is associated with significant morbidity and mortality, particularly due to cardiovascular disease. An emerging cardiovascular risk factor, arterial stiffness, may also be involved in the cardiovascular complications of obstructive sleep apnea. The purpose of this review was to summarize the current literature regarding the effect of obstructive sleep apnea on arterial stiffness. We conducted a systematic literature review using PubMed, Embase and the Cochrane Library. We identified 24 studies that met search criteria investigating the effect of obstructive sleep apnea on arterial stiffness. Arterial stiffness was found to be increased in obstructive sleep apnea patients compared with controls or increased in severe compared with mild sleep apnea. In some studies, a positive correlation was identified between the degree of arterial stiffness and sleep apnea severity. In the two randomized, controlled trials and the two nonrandomized trials identified, treatment of obstructive sleep apnea with continuous positive airway pressure led to significant decreases in arterial stiffness. Obstructive sleep apnea appears to have an independent effect on arterial stiffness, which may be one of the mechanisms accounting for sleep apnea-associated cardiovascular risk.

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Section: Resultsmentioning

confidence: 97%

Increased arterial stiffness in obstructive sleep apnea: a systematic review

et al. 2010

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“…This observation remained significant even after adjustment for change of the blood pressure; therefore, metabolic syndrome may accelerate age-related increase of structural arterial stiffness. Sleep apnea is also a risk factor for accelerated increase of the brachial-ankle PWV 32,33) . Sympathetic nervous activation induced by hypoxia resulting from apnea may be one of the mechanisms underlying the accelerated increase of the arterial stiffness in subjects with sleep apnea 34) .…”

Section: Metabolic Syndrome Sleep Apnea and Obesitymentioning

confidence: 99%

Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

Tomiyama

Matsumoto

Shiina

et al. 2016

J Atheroscler Thromb

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Since 2001, brachial-ankle pulse wave velocity (brachial-ankle PWV) measurement has been applied for risk stratification of patients with atherosclerotic cardiovascular disease and/or its risk factors in Japan. Measurement of the brachial-ankle PWV is simple and well standardized, and its reproducibility and accuracy are acceptable. Several cross-sectional studies have demonstrated a significant correlation between the brachial-ankle PWV and known risk factors for cardiovascular disease; the correlation is stronger in subjects with cardiovascular disease than in those without cardiovascular disease. We conducted a meta-analysis, which demonstrated that the brachial-ankle PWV is an independent predictor of future cardiovascular events. Furthermore, the treatment of cardiovascular risk factors and lifestyle modifications have been shown to improve the brachial-ankle PWV. Thus, at present, brachial-ankle PWV is close to being considered as a useful marker in the management of atherosclerotic cardiovascular disease and/or its risk factors.

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“…Several studies have reported that continuous positive airway pressure therapy decreases blood pressure and PWV in SDB patients with hypertension in both the short‐term and long‐term 37, 38, 39. Additionally, meta‐analysis has demonstrated that continuous positive airway pressure improves aortic stiffness in patients with OSA 40.…”

Section: Discussionmentioning

confidence: 99%

Association between sleep‐disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction

et al. 2018

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AimsSleep‐disordered breathing (SDB) is associated with arterial stiffness, which may be one of the factors that lead to heart failure (HF). We examined the relationship between pulse wave velocity (PWV) and SDB in patients who have HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF).Methods and resultsWe measured the apnoea–hypopnoea index (AHI) by polysomnography, echocardiographic parameters, and PWV in 221 HF patients. Age, blood pressure, and PWV were higher in HFpEF (ejection fraction > 50%, n = 70) patients than in HFrEF (ejection fraction < 50%, n = 151) patients. All HF patients were divided into three groups according to AHI: none‐to‐mild SDB group (AHI < 15 times/h, n = 77), moderate SDB group (15 < AHI < 30 times/h, n = 59), and severe SDB group (AHI > 30 times/h, n = 85). Although blood pressure and echocardiographic parameters did not differ among the three groups, PWV was significantly higher in the severe SDB group than in the none‐to‐mild and moderate SDB groups (P = 0.002). When the HFrEF and HFpEF patients were analysed separately, PWV was significantly higher in the severe SDB group than in the none‐to‐mild and moderate SDB groups in patients with HFpEF (P = 0.002), but not in those with HFrEF (P = 0.068). In the multiple regression analysis to determine PWV, the presence of severe SDB was found to be an independent predictor of high PWV in HFpEF (β = 0.234, P = 0.005), but not in HFrEF patients.ConclusionsSevere SDB is associated with elevated arterial stiffness and may be related to the pathophysiology of HF, especially in HFpEF patients.

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Effects of long-term treatment for obstructive sleep apnea on pulse wave velocity

Cited by 29 publications

References 29 publications

Increased arterial stiffness in obstructive sleep apnea: a systematic review

Increased arterial stiffness in obstructive sleep apnea: a systematic review

Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

Association between sleep‐disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction

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