Effects of Long-Term Thyroid Hormone Level Alterations, n-3 Poly-unsaturated Fatty Acid Supplementation and Statin Administration in Rats

Soukup, Tomáš

doi:10.33549/physiolres.932623

Cited by 10 publications

(2 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental studies that have evaluated the thyroidal effects of the omega-3 PUFA ( 137 – 143 ) are summarized in Table 5 . Omega-3 PUFA were shown to have a neuroprotective ( 138 , 139 ) and cardioprotective ( 143 ) action on unfavorable effects caused by thyroid hormone deficiency.…”

Section: Omega-3 Pufa-based Nutraceuticals In the Setting Of Thyroid ...mentioning

confidence: 99%

“…Omega-3 PUFA were shown to have a neuroprotective ( 138 , 139 ) and cardioprotective ( 143 ) action on unfavorable effects caused by thyroid hormone deficiency. On the other hand, the omega-3 PUFA mitigate, ameliorate certain hyperthyroidism-induced unfavorable effects, such as arrhythmias ( 141 ) and hepatic dysfunction ( 137 ). Such favorable effects of the omega-3 PUFA on consequences in the peripheral tissues that are caused by opposite states of thyroid dysfunction confer to the omega-3 PUFA a modulatory role that is reminiscent of another dietary nutrient, L-carnitine.…”

Section: Omega-3 Pufa-based Nutraceuticals In the Setting Of Thyroid ...mentioning

confidence: 99%

See 1 more Smart Citation

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

et al. 2022

View full text Add to dashboard Cite

Benefits of the omega-3 polyunsaturated fatty acids (PUFA) on a number of clinical disorders, including autoimmune diseases, are widely reported in the literature. One major dietary source of PUFA are fish, particularly the small oily fish, like anchovy, sardine, mackerel and others. Unfortunately, fish (particularly the large, top-predator fish like swordfish) are also a source of pollutants, including the heavy metals. One relevant heavy metal is mercury, a known environmental trigger of autoimmunity that is measurable inside the thyroid. There are a number of interactions between the omega-3 PUFA and thyroid hormones, even at the level of the thyroid hormone transport proteins. Concerning the mechanisms behind the protection from/amelioration of autoimmune diseases, including thyroiditis, that are caused by the omega-3 PUFA, one can be the decreased production of chemokines, a decrease that was reported in the literature for other nutraceuticals. Recent studies point also to the involvement of resolvins. The intracellular increase in resolvins is associated with the tissue protection from inflammation that was observed in experimental animals after coadministration of omega-3 PUFA and thyroid hormone. After having presented data on fish consumption at the beginning, we conclude our review by presenting data on the market of the dietary supplements/nutraceuticals. The global omega-3 products market was valued at USD 2.10 billion in 2020, and was projected to go up at a compound annual growth rate of 7.8% from 2020 to 2028. Among supplements, fish oils, which are derived mainly from anchovies, are considered the best and generally safest source of omega-3. Taking into account (i) the anti-autoimmunity and anti-cancer properties of the omega-3 PUFA, (ii) the increasing incidence of both autoimmune thyroiditis and thyroid cancer worldwide, (iii) the predisposing role for thyroid cancer exerted by autoimmune thyroiditis, and (iv) the risk for developing metabolic and cardiovascular disorders conferred by both elevated/trendwise elevated serum TSH levels and thyroid autoimmunity, then there is enough rationale for the omega-3 PUFA as measures to contrast the appearance and/or duration of Hashimoto’s thyroiditis as well as to correct the slightly elevated serum TSH levels of subclinical hypothyroidism.

show abstract

Section: Omega-3 Pufa-based Nutraceuticals In the Setting Of Thyroid ...mentioning

confidence: 99%

Section: Omega-3 Pufa-based Nutraceuticals In the Setting Of Thyroid ...mentioning

confidence: 99%

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

et al. 2022

View full text Add to dashboard Cite

show abstract

Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status

Kopecká

Zachařová

Smerdu³

et al. 2014

Histochem Cell Biol

View full text Add to dashboard Cite

We studied the effect of regeneration, altered innervation and thyroid hormone (TH) levels on fiber type transitions in slow soleus (SOL) muscles grafted (GRAFT) into host extensor digitorum longus (EDLh) muscles of euthyroid (EU), hyperthyroid (HT) and hypothyroid (HY) Lewis strain rats. SOL muscles were excised from 3-week to 4-week-old inbred Lewis rats and intramuscularly transplanted into EDLh muscles of 2-month-old female rats of the same strain. The proportions of type 1, 2A, 2X and 2B fibers of GRAFT were determined by immunohistochemistry and compared with those of EDLh muscle and EDL and SOL muscles of the unoperated contralateral hind limb. After an average regeneration period of 6-7 months and after being reinnervated by the "fast" peroneal nerve of EDLh muscle, GRAFT was transformed into a fast muscle. However, the extent of GRAFT transformation varied with different TH states. In the EU rats, GRAFT contained about 95 % of fast fibers, among which type 2X and 2B fibers predominated (about 75 %). The transition toward fast muscle phenotype was more pronounced in HT status, where the fastest type 2B fibers predominated. On the contrary, in HY status, the slow to fast transformation was less pronounced, as GRAFT contained less type 2B and 2X but more type 2A and 1 fibers. We conclude that the type of innervation is the crucial factor for the slow to fast fiber type transitions in GRAFT, but the extent of muscle transformation is further modulated by altered TH status.

show abstract

Effect of altered innervation and thyroid hormones on myosin heavy chain expression and fiber type transitions: a mini-review

Soukup

Smerdu

2014

Histochem Cell Biol

View full text Add to dashboard Cite

In this mini-review, we briefly present the data regarding the effect of extrinsic factors, i.e., innervation and thyroid hormones (TH) on myosin heavy chain genes and isoforms expression and consequently on muscle fiber type transitions. It has been well known that reduced neuromuscular activity, hyperthyroidism or mechanical unloading stimulate slow-to-fast fiber type transitions, while increased neuromuscular activity, hypothyroidism and higher mechanical loading result in fast to slow fiber type transitions. As there is a plethora of results on these topics, we focus mostly on data relevant to our experimental model of slow-to-fast muscle transformation following heterochronous intramuscular isotransplantation in rats with altered TH status.

show abstract

Effects of Long-Term Thyroid Hormone Level Alterations, n-3 Poly-unsaturated Fatty Acid Supplementation and Statin Administration in Rats

Cited by 10 publications

References 115 publications

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

Fish and the Thyroid: A Janus Bifrons Relationship Caused by Pollutants and the Omega-3 Polyunsaturated Fatty Acids

Slow to fast muscle transformation following heterochronous isotransplantation is influenced by host thyroid hormone status

Effect of altered innervation and thyroid hormones on myosin heavy chain expression and fiber type transitions: a mini-review

Contact Info

Product

Resources

About