2009
DOI: 10.1016/j.jpeds.2008.09.021
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Effects of Long-Term Sildenafil Treatment for Pulmonary Hypertension in Infants with Chronic Lung Disease

Abstract: Objective-To determine the clinical course and outcomes of infants with chronic lung disease (CLD) and pulmonary hypertension (PH) who received prolonged sildenafil therapy.Study design-Retrospective review of 25 patients < 2 years of age with CLD in whom sildenafil was initiated for the treatment of PH while hospitalized from January 2004 -October 2007. Hemodynamic improvement was defined by a 20% decrease in the ratio of pulmonary to systemic systolic arterial pressure or improvement in the degree of ventric… Show more

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Cited by 238 publications
(197 citation statements)
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References 43 publications
(34 reference statements)
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“…Estimated right ventricular peak systolic pressure greater than half the systemic systolic blood pressure was considered to be consistent with PH. 1,8 A tricuspid regurgitation jet was measured to calculate estimated right ventricular peak systolic pressure using the Bernoulli equation and then adding the assumed right atrial pressures. 11,12 When a tricuspid regurgitation jet was not visualized, then degree of septal flattening and presence of bidirectional shunting was felt to be consistent with PH.…”
Section: Diagnosis Of Phmentioning
confidence: 99%
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“…Estimated right ventricular peak systolic pressure greater than half the systemic systolic blood pressure was considered to be consistent with PH. 1,8 A tricuspid regurgitation jet was measured to calculate estimated right ventricular peak systolic pressure using the Bernoulli equation and then adding the assumed right atrial pressures. 11,12 When a tricuspid regurgitation jet was not visualized, then degree of septal flattening and presence of bidirectional shunting was felt to be consistent with PH.…”
Section: Diagnosis Of Phmentioning
confidence: 99%
“…Previous data suggest that sildenafil citrate has a rapid onset of action, which is evident in treatment of neonatal persistent pulmonary arterial hypertension. 8,9 FiO 2 requirement and highest capillary pCO 2 within the 24 h before starting, 24 h after starting and 48 h after starting sildenafil citrate were also recorded.…”
Section: Baseline Assessmentmentioning
confidence: 99%
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“…Debido a esto último, se debe vigilar la aparición de hipotensión sistémica como efecto adverso a su uso. Con esta droga sólo existen series retrospectivas de menos de 25 pacientes cada una las que en grado variable han mostrado mejoría ecocardiográfica y clínica de su HP 22,23,24,25 . El estudio más completo parece ser el de Trottier-Boucher et al, que muestra una mejoría ecocardiográfica y clínica en 74 y 35% de sus pacientes respectivamente.…”
Section: Terapias Específicasunclassified
“…Силденафил (код АТХ: G04BE03) используется у детей с БЛД при стойкой ЛГ, рефрактерной к стандарт-ной терапии, особенно при отсутствии возможности проведения ингаляций оксида азота (NO) и экстракорпо-ральной мембранной оксигенации (ранее допускалось применение в режиме off label после получения инфор-мированного согласия родителей, согласия Локального этического и Формулярного комитетов в условиях специ-ализированного стационара, с вариабельностью дозы от 1 до 8 мг/кг в сут) [62][63][64]. Однако, было отмечено, что силденафил увеличивает риск тяжелой ретинопатии недоношенных [65].…”
Section: (2с)unclassified