Effects of long-term exposure to manganese chloride on fertility of male and female mice

Histological Alteration Induced by Manganese chloride in the Male Testes, Epididymis and Kidney of the Albino Rats

“…These findings are in agreement with that reported by [19 ]. Who reported oral manganese chloride exposure seems to trigger reduced fertility in mice at very high doses .…”

Assessment of sperm production and reproductive organs of Wistar rats to long-term exposure of Caesalpinia ferrea

“…A weight loss of the reproductive organs is under hormonal control and could suggest a disturbance of the reproductive endocrine functions (Elbetieha et al 2001). In the testis, the production of sex steroid hormones and male gametes is regulated by the folliclestimulating hormone (FSH) and luteinizing hormone (LH), which are secreted by the pituitary gland.…”

Bone manganese as a biomarker of manganese exposure: A feasibility study

“…There is also concern about increasing environmental exposure to Mn, linked to the use of methylcyclopentadienyl-Mn-tricarbonyl (MMT) as a gasoline anti-knock additive in several countries, including Canada [Finkelstein and Jerrett, 2007]. Toxic levels of Mn have been known to cause reproductive and immune dysfunction as well as liver and testicular damage [Donaldson, 1987;Sanchez et al, 1993;Elbetieha et al, 2001] and morbidity increases with the length of exposure. Elevated endogenous Mn exposure may occur in patients suffering from chronic liver disease (e.g., cirrhosis, impaired biliary elimination), while exogenous Mn exposure may happen in patients receiving total parenteral nutrition or after injection of Mn-based contrast agents used prior to MRI scans [Gallez et al, 2001].…”