Effects of Long-Term Exposure of Exogenous Advanced Glycation Endproducts on Vertebral Bone Microarchitecture; Sex-Differences on Structure Derived Mechanical Properties
Abstract:Introduction
Accumulation of advanced glycation end products (AGE) are commonly associated with diabetic complications, including increased painful intervertebral disc pathologies, osteoporosis, and bone fracture risk. Exogenous AGEs develop by processing food at high temperatures and can accumulate in bone where they crosslink collagen. A clinical study reported association of increased serum AGE levels with vertebral fracture risk in women but not in men, highlighting gender effects. The purpose of this stud… Show more
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