Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients

Sakurai, Yoshinori; Oh-oka, Yuriko; Kato, Shiho; Suzuki, Syoichi; Hayakawa, Mika; Masui, Toshihiko; Yoshida, Ikuo; Tonomura, Shuhei; Miyake, Shoji; Nakamura, Yasuko; Uyama, Ichiro; Komori, Yoshiyuki; Ochiai, Masahiro

doi:10.1016/j.nut.2006.03.014

Cited by 14 publications

(8 citation statements)

References 44 publications

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“…Although the mechanism remains unclear, a preoperative immune-enhanced diet may impose a load on hepatocytes after invasive surgery such as PD. Immune-enhanced formulas have been suggested to possibly cause a high postoperative BUN level as a result of an overload in nitrogen intake [41]. However, in the present series, we did not observe a marked change in the BUN level, and nitrogen overloading did not appear to be excessive.…”

Section: Discussioncontrasting

confidence: 90%

Compliance with and effects of preoperative immunonutrition in patients undergoing pancreaticoduodenectomy

Soejima

Kinoshita

Gotohda

et al. 2011

J Hepato Biliary Pancreat

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Section: Discussioncontrasting

confidence: 90%

Compliance with and effects of preoperative immunonutrition in patients undergoing pancreaticoduodenectomy

Soejima

Kinoshita

Gotohda

et al. 2011

J Hepato Biliary Pancreat

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“…For adult medical nutrition products, elderly residents in a long‐term care facility were fed enterally for 12 weeks either a standard formula without any added nucleotides or an immune‐modulating formula that contained 1.3 g/L of nucleotides as yeast RNA. No differences related to feeding parameters or safety measures were observed 136 …”

Section: Representative Animal Studies With Nucleotidesmentioning

confidence: 90%

The Role of Nucleotides in the Immune and Gastrointestinal Systems

2012

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Nucleotides are low molecular weight biological molecules key to biochemical processes. Sources include de novo synthesis, recovery via salvage mechanisms, and dietary intakes. Although endogenous production serves as the main nucleotide source, evidence suggests that exogenous sources are essential to immune competence, intestinal development, and recovery. Dietary nucleotides serve a marked role in rapidly proliferating cells where they are necessary for optimal function. Accordingly, dietary nucleotides are deemed conditionally essential in the presence of various physiological stresses, including growth and development, recovery from injury, infection, and certain disease states. Clinical studies that evaluated nutrition formulations of nucleotides in combination with other specific nutrient substances demonstrated improved clinical outcomes in patients characterized as critically ill, injured, immune suppressed, or with chronic gastrointestinal conditions. However, conclusions regarding specific benefits of nucleotides are limited. Scientific substantiation of nucleotide supplementation in infant formula has been reported to improve the maturation and development of the intestinal tract as well as immune function. All medical nutrition products except for one immune-modulating formulation are devoid of nucleotides. In an effort to build on this, the current review presents the data to support potential clinical applications for nucleotides in enteral nutrition that may contribute to improved outcomes in physiologically stressed patients.

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“…On the other hand, Sakurai et al [37] (in non-surgical patients) administered enteral immunonutrition to their patients for 12 wk with positive results. In our opinion, such a delay is not acceptable for patients who will undergo cancer surgery.…”

Section: Discussionmentioning

confidence: 99%

Effect of preoperative immunonutrition and other nutrition models on cellular immune parameters

Günerhan¹,

Köksal²,

Sahin³

et al. 2009

WJG

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AIM:To e va l u a t e t h e e f fe c t s o f p r e o p e ra t i v e immunonutrition and other nutrition models on the cellular immunity parameters of patients with gastrointestinal tumors before surgical intervention. In addition, effects on postoperative complications were examined. METHODS:Patients with gastrointestinal tumors were randomized into 3 groups. The immunonutrition group received a combination of arginine, fatty acids and nucleotides. The second and third group received normal nutrition and standard enteral nutrition, respectively. Nutrition protocols were administered for 7 d prior to the operation. Nutritional parameters, in particular prealbumin levels and lymphocyte subpopulations (CD4+, CD8+, CD16+/56+, and CD69 cells) were evaluated before and after the nutrition protocols. Groups were compared in terms of postoperative complications and duration of hospital stay. RESULTS:Of the 42 patients who completed the study, 16 received immunonutrition, 13 received normal nutrition and 13 received standard enteral nutrition. prealbumin values were low in every group, but this parameter was improved after the nutritional protocol only in the immunonutrition group (13.64 ± 8.83 vs 15.98 ± 8.66, P = 0.037). Groups were similar in terms of CD4+, CD16+/56, and CD69+ prior to the nutritional protocol; whereas CD8+ was higher in the standard nutrition group compared to the immunonutrition group. After nutritional protocols, none of the groups had an increase in their lymphocyte subpopulations. Also, groups did not differ in terms of postoperative complications and postoperative durations of hospital stay.CONCLUSION: P re o p e ra t i ve i m m u n o n u t r i t i o n provided a significant increase in prealbumin levels, while it did not significantly alter T lymphocyte subpopulation counts, the rate of postoperative complications and the duration of hospital stay.

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Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients

Cited by 14 publications

References 44 publications

Compliance with and effects of preoperative immunonutrition in patients undergoing pancreaticoduodenectomy

Compliance with and effects of preoperative immunonutrition in patients undergoing pancreaticoduodenectomy

The Role of Nucleotides in the Immune and Gastrointestinal Systems

Effect of preoperative immunonutrition and other nutrition models on cellular immune parameters

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