Effects of Long-term Consumption of a Fermented Infant Formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on Acute Diarrhea in Healthy Infants

Thibault, Hélène; Aubert-Jacquin, C.; Goulet, Olivier

doi:10.1097/00005176-200408000-00004

Cited by 165 publications

(140 citation statements)

References 36 publications

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“…This study is the first to show the early and persisting protective effect of a fermented infant formula without live bacteria, and containing intact, not hydrolyzed CM proteins, on biological tests and PAAEs in infants with family history of atopy. Previous preclinical and clinical studies suggest that this may be related to the positive effect of HKBBST milk on intestinal flora and thymus size in healthy infants (Thibault et al, 2004;Indrio et al, 2007).…”

Section: Discussionmentioning

confidence: 96%

“…Milk fermented with these two bacteria and heated to kill ferments has shown to modify intestinal microbiota in animals and humans (Romond et al, 1997(Romond et al, , 1998Thibault et al, 2004), to strengthen intestinal barrier in mice (Menard et al, 2006) and to prevent the increase of thymus size in non-breastfed, healthy term infants (Indrio et al, 2007). Moreover, the metabolites of these ferments exert immunomodulatory properties, partly through dendritic cells (Menard et al, 2004;Hoarau et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

et al. 2010

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Background/Objectives: To determine the impact of a not hydrolyzed fermented infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus thermophilus 065 (HKBBST) on the incidence of allergy-like events during the first 2 years of life in children at high risk of atopy. Subjects/Methods: This multicenter, randomized, double-blind, controlled study included infants at high risk of atopy. Infants used HKBBST or a standard infant formula (SIF) since birth until 1 year of age, and were followed at 4, 12 and 24 months after birth. Skin prick tests (SPTs) for six foods and six aeroallergens were systematically performed and adverse events (AEs) were recorded. In case of potentially allergic AE (PAAE), allergy could be further tested by SPT, patch tests and quantification of specific IgEs. If cow's milk allergy (CMA) was suspected, an oral challenge could also be performed. Results: The study included 129 children, 63 were randomized to SIF, 66 to HKBBST. The use of HKBBST milk did not alter the proportion of CMA but decreased the proportion of positive SPT to cow's milk (1.7 vs 12.5%, P ¼ 0.03), and the incidence of digestive (39 vs 63%, P ¼ 0.01) and respiratory potentially allergic AEs (7 vs 21%, P ¼ 0.03) at 12 months, and that of respiratory PAAEs at 24 months (13 vs 35%, P ¼ 0.01). Conclusions: HKBBST decreased the incidence of PAAEs in children with family history of atopy, during the first months of life and after the formula was stopped. Oral tolerance to cow's milk in infants at high risk of atopy may therefore be improved using not hydrolyzed fermented formulae.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

et al. 2010

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“…[32][33][34][35] Most of the studies were conducted in child care centers. The strains of probiotics used included LGG, S thermophilus, Lactobacillus casei, B lactis, or Lactobacillus reuteri mixed with milk or infant formula or given as an oral supplement.…”

Section: Prevention Of Acute Infectious Diarrheamentioning

confidence: 99%

Probiotics and Prebiotics in Pediatrics

Thomas¹,

Greer²

2010

Pediatrics

356

220

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This clinical report reviews the currently known health benefits of probiotic and prebiotic products, including those added to commercially available infant formula and other food products for use in children. Probiotics are supplements or foods that contain viable microorganisms that cause alterations of the microflora of the host. Use of probiotics has been shown to be modestly effective in randomized clinical trials (RCTs) in (1) treating acute viral gastroenteritis in healthy children; and (2) preventing antibiotic-associated diarrhea in healthy children. There is some evidence that probiotics prevent necrotizing enterocolitis in very low birth weight infants (birth weight between 1000 and 1500 g), but more studies are needed. The results of RCTs in which probiotics were used to treat childhood Helicobacter pylori gastritis, irritable bowel syndrome, chronic ulcerative colitis, and infantile colic, as well as in preventing childhood atopy, although encouraging, are preliminary and require further confirmation. Probiotics have not been proven to be beneficial in treating or preventing human cancers or in treating children with Crohn disease. There are also safety concerns with the use of probiotics in infants and children who are immunocompromised, chronically debilitated, or seriously ill with indwelling medical devices. Prebiotics are supplements or foods that contain a nondigestible food ingredient that selectively stimulates the favorable growth and/or activity of indigenous probiotic bacteria. Human milk contains substantial quantities of prebiotics. There is a paucity of RCTs examining prebiotics in children, although there may be some long-term benefit of prebiotics for the prevention of atopic eczema and common infections in healthy infants. Confirmatory well-designed clinical research studies are necessary.

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“…Furthermore, bifidobacteria are considered to be the most important health-beneficial bacteria for infants. First, bifidobacteria plays an important antiinflammatory role on the mucosal surface (6) and can provide protection against enteric and systemic disorders caused by bacterial pathogens (7). Second, probiotics, including bifidobacteria might be related to the establishment of allergies (8,9), and thus, play a role in the prevention of allergic disease (10).…”

mentioning

confidence: 99%

Influence of Maternal Bifidobacteria on the Establishment of Bifidobacteria Colonizing the Gut in Infants

et al. 2009

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ABSTRACT:The aim of this study was to examine the influence of maternal intestinal and vaginal bifidobacteria on the establishment of bifidobacteria colonizing the gut in infants. Fecal samples from 110 healthy pregnant mothers within 1 mo before delivery and their babies at 1 mo of age and 100 vaginal swabs from the mother within 7 d before delivery were collected at a maternity hospital in Fukuoka city, Japan. The fecal and vaginal samples were assayed by PCR to detect Bifidobacterium species and by real-time PCR assays to estimate the bifidobacterial number. The detection of Bifidobacterium breve in the mothers' feces was significantly associated with increases in both the bifidobacterial counts and number of Bifidobacterium species in the babies' feces. In addition, a cesarean section was significantly associated with both a decrease in the counts and diversity of bifidobacteria in the babies' feces. The number of Bifidobacterium species detected in the vaginal swabs of mothers were not associated with either the bifidobacterial counts or the diversity of bifidobacteria in the babies' feces. The most important determinants of intestinal bifidobacteria in infants were the colonization of B. breve in the mothers' gut and vaginal delivery.

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Effects of Long-term Consumption of a Fermented Infant Formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on Acute Diarrhea in Healthy Infants

Abstract: A fermented formula may reduce the severity of acute diarrhea among healthy young infants. This outcome may be linked to the bifidogenic effects of fermentation products and their interactions with the intestinal immune system.

Cited by 165 publications

References 36 publications

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

Probiotics and Prebiotics in Pediatrics

Influence of Maternal Bifidobacteria on the Establishment of Bifidobacteria Colonizing the Gut in Infants

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